Aromatic and monoterpene alcohol accumulation by Eremothecium ashbyi strains differing in riboflavinogenesis

Семенова, Е. Ф.; Shpichka, Anastasia; Presnyakova, E. V.

doi:10.1134/s0003683817030139

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…Fermentation and oil extraction. E. ashbyi (VKM F-3009, VKM F-4565, and VKM F-4566) and E. gossypii (VKM F-3296) strains were stored on potato dextrose, Sabouraud’s, and Czapek’s media [ 20 , 21 , 22 ]. To prepare the inoculum, we used the glucose–peptone liquid medium (glucose—7.5 g/L; peptone—4.0 g/L; sodium succinate—2.0 g/L; potassium phosphate dibasic—0.5 g/L; inositol—0.14 g/L; pH 6.5) and cultured it for 48 h at a temperature of 20–24 °C.…”

Section: Methodsmentioning

confidence: 99%

The In Vitro Cytotoxicity of Eremothecium oil and Its Components—Aromatic and Acyclic Monoterpene Alcohols

Семенова

Presniakova

Kozlovskaya³

et al. 2022

IJMS

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The microscopic fungi Eremothecium ashbyi and E. gossypii are known for their ability to synthetize essential oil, which has a composition similar to that of rose oil. The development of Eremothecium oil technology enables the production of rose-scented products, which are demanded by pharmaceutical, food, and perfumery industries. This study focuses on assessing the in vitro cytotoxicity of Eremothecium oil, in comparison with that of rose oil, using a combination of methods and two cell types (3T3 mouse fibroblast cell line and bone-marrow-derived mesenchymal stromal cells (BM-MSCs)). The Eremothecium oil samples possessed cytotoxic effects that varied among strains and batches. The revealed cytotoxicity level may be used to tailor the qualitative and quantitative composition of Eremothecium oil to achieve a particular quality in its end products. These results require further analysis using other cell types and assays based on measuring other cell functions.

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Section: Methodsmentioning

confidence: 99%

The In Vitro Cytotoxicity of Eremothecium oil and Its Components—Aromatic and Acyclic Monoterpene Alcohols

Семенова

Presniakova

Kozlovskaya³

et al. 2022

IJMS

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“…Along with other species of the genus, E. ashbyi has been widely used in biotechnology since the 1950s for production of useful compounds. The main interest has been the overproduction of riboflavins by some strains (Kapralek, 1962; Semenova et al., 2017). Additionally, some studies report extraction of accumulated lipids and essential oils from the biomass of E. ashbyi (He et al., 2019; Vijayalakshmi et al., 2003).…”

Section: Assessmentmentioning

confidence: 99%

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 14: suitability of taxonomic units notified to EFSA until March 2021

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2021

EFS2

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The qualified presumption of safety (QPS) approach was developed to provide a regularly updated generic pre-evaluation of the safety of biological agents, intended for addition to food or feed, to support the work of EFSA's Scientific Panels. The QPS approach is based on an assessment of published data for each agent, with respect to its taxonomic identity, the body of relevant knowledge, safety concerns and occurrence of antimicrobial resistance. Safety concerns identified for a taxonomic unit (TU) are, where possible, confirmed at the species/strain or product level and reflected by 'qualifications'. In the period covered by this statement, no new information was found that would change the status of previously recommended QPS TUs. Schizochytrium limacinum, which is a synonym for Aurantiochytrium limacinum, was added to the QPS list. Of the 78 microorganisms notified to EFSA between October 2020 and March 2021, 71 were excluded; 16 filamentous fungi, 1 Dyella spp., 1 Enterococcus faecium, 7 Escherichia coli, 1 Streptomyces spp., 1 Schizochytrium spp. and 44 TUs that had been previously evaluated. Seven TUs were evaluated: Corynebacterium stationis and Kodamaea ohmeri were re-assessed because an update was requested for the current mandate. Anoxybacillus caldiproteolyticus, Bacillus paralicheniformis, Enterobacter hormaechei, Eremothecium ashbyi and Lactococcus garvieae were assessed for the first time. The following TUs were not recommended for QPS status: A. caldiproteolyticus due to the lack of a body of knowledge in relation to its use in the food or feed chain, E. hormaechei, L. garvieae and K. ohmeri due to their pathogenic potential, E. ashbyi and C. stationis due to a lack of body of knowledge on their occurrence in the food and feed chain and to their pathogenic potential. B. paralicheniformis was recommended for the QPS status with the qualification 'absence of toxigenic activity' and 'absence of genetic information to synthesize bacitracin'.

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“…[3][4][5] We assessed antimicrobial activity using 27 bacteria and fungi cultures via two methods: disk-diffusion and serial dilutions. Oil toxic effects were revealed using in vitro biotesting with Paramecium caudatum.…”

Section: Methodsmentioning

confidence: 99%

“…1 In 1986, Bugorskiy et al revealed that homothallic ascomycetes Eremothecium ashbyi and E. gossypii are able to produce rose-scented essential oil, whose composition is similar to that of natural rose essential oil. 2 While previous studies have mainly focused on the study of fundamental problems, [1][2][3][4][5] none have assessed the biological activity of this new pharmaceutical substance (Eremothecium oil). In this study, we, therefore, sought to reveal its antimicrobial and toxic effects depending on its component composition.…”

Section: Introductionmentioning

confidence: 99%

Development of a Novel Biotechnological Fragrant Product, Eremothecium Oil

Семенова¹,

Shpichka²,

Elena³

et al. 2017

IJPER

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The assessment of Eremothecium oil biological activity via kinetics modelling revealed valid positive correlations between level of bacterial multiplication and lag-phase prolongation under different concentrations (from 0.49 to 7.81 µL/mL). Toxicity intensity correlated with phenyl ethanol (R = -0.9; strong negative association), geraniol (R = 0.6; moderate positive association), nerol (R = -0.55; moderate negative association), linalool (R = -0.74; strong negative association), and total monoterpene alcohol (R = 0.5; moderate positive association) content.

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Aromatic and monoterpene alcohol accumulation by Eremothecium ashbyi strains differing in riboflavinogenesis

Cited by 6 publications

References 10 publications

The In Vitro Cytotoxicity of Eremothecium oil and Its Components—Aromatic and Acyclic Monoterpene Alcohols

The In Vitro Cytotoxicity of Eremothecium oil and Its Components—Aromatic and Acyclic Monoterpene Alcohols

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 14: suitability of taxonomic units notified to EFSA until March 2021

Development of a Novel Biotechnological Fragrant Product, Eremothecium Oil

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