Aromatic Acids and Leucine Derivatives Produced from the Deep-Sea Actinomycetes Streptomyces chumphonensis SCSIO15079 with Antihyperlipidemic Activities

Abstract

Six new aromatic acids (1–6) and three new leucine derivatives containing an unusual oxime moiety (7–9) were isolated and identified from the deep-sea-derived actinomycetes strain Streptomyces chumphonensis SCSIO15079, together with two known compounds (10–11). The structures of 1–9 including absolute configurations were determined by detailed NMR, MS, and experimental and calculated electronic circular dichroism spectroscopic analyses. Compounds 1–9 were evaluated for their antimicrobial and cytotoxicity activities, as well as their effects on intracellular lipid accumulation in HepG2 cells. Compounds 3 and 4, with the most potent inhibitory activity on intracellular lipid accumulation at 10 μM, were revealed with potential antihyperlipidemic effects, although the mechanism needs to be further studied.

Marine natural products

“…Compound 100 was reported as a MNP for the first time. 28 Two dimeric benzoic polyene acids, youssoufenes A2 101 and A3 102 were reported from a dtlA activated mutant of a S. youssoufiensis strain. 29 A sediment-derived Streptomyces strain yielded 11 napthalenic macrolides, hygrocins K–U 103 – 113 and one phenylpropanamide derivative, streptobenzenepropanamide A 114 .…”