Aromatase inhibitors: past, present and future

Séralini, Gilles‐Éric; Moslemi, Safa

doi:10.1016/s0303-7207(01)00433-6

Cited by 107 publications

(64 citation statements)

References 129 publications

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“…Unfortunately, however, there are no currently available data for environmental concentrations of LET. Besides the two chemicals tested here and other related pharmaceuticals, a large number of chemicals present in the environment have been found to be capable of eliciting directacting antiestrogenic activity and/or inhibiting aromatase activity (Seralini and Moslemi, 2001;Ankley et al, 2002;Hinfray et al, 2006). It should be noted that the concentrations of estrogen and antiestrogens used in this laboratory study, as well as their ratios, cannot exactly reflect the real exposure situations of aquatic organisms that would be expected in environmental samples.…”

Section: Discussionmentioning

confidence: 83%

Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes)

2009

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a b s t r a c tIt is supposed that the estrogenic effects of estrogenic chemicals will be balanced by the presence of other endocrine-disrupting chemicals (EDCs) with different properties. However, little convincing research into this issue has been carried out to date. In the present study, the combined effects of EDCs with estrogenic and antiestrogenic activities were assessed using a 21-day reproduction assay with the Japanese medaka (Oryzias latipes) as an in vivo model. Natural estrogen (17␤-estradiol, E2) and the pharmaceutical substances letrozole and tamoxifen, which are both model antiestrogens, were tested as reference compounds individually and in combination. Exposure to E2 (200 ng/L) alone resulted in significant biological changes in paired fish, including impaired reproductive capacity and plasma vitellogenin induction. Upon coexposure with tamoxifen or letrozole (10, 50 and 250 g/L), the effects of estrogen on some biomarkers (e.g., plasma vitellogenin concentration) could be neutralized to some extent, but the impairments in reproductive performance were hardly ameliorated or even became more severe. Since reproductive performance is a more holistic parameter with population-level relevance, the possibility that the effects of estrogenic chemicals can be cancelled out by the presence of antiestrogens in aquatic organisms should be questioned. Our observations also illustrate the importance of considering multiple endpoints at different biological levels of organisms for accurate and adequate assessment of the integrated effects of EDCs, especially in environmentally relevant exposure situations.

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Section: Discussionmentioning

confidence: 83%

Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes)

2009

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“…It is considered a limiting factor involved in estrogen synthesis and, thus, in physiologic functions, including female and male gametogenesis (Carreau 2001), reproduction, sex differentiation, and even bone growth. It is also pharmacologically controlled in the treatment of estrogen-dependent cancers (SØralini and Moslemi 2001).…”

Section: Abstract Roundupmentioning

confidence: 99%

Time- and Dose-Dependent Effects of Roundup on Human Embryonic and Placental Cells

Bénachour

Sipahutar

Moslemi

et al. 2007

Arch Environ Contam Toxicol

203

118

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“…The effects of body weight and age of Nile tilapia on microsome yield and the effect of pH on the aromatase activity of the microsomes obtained were investigated. Three active compounds, chrysin, quercetin, and quercitrin, were previously reported to have antiaromatase activity (23,24). However, the antiaromatase activity of these compounds has yet to be compared.…”

Section: Introductionmentioning

confidence: 99%

Investigation of antiaromatase activity using hepatic microsomes of Nile tilapia (<i>Oreochromis niloticus</i>)

Sassa-deepaeng

Chaisri

Pikulkaew

et al. 2017

DD&T

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Aromatase inhibitors: past, present and future

Cited by 107 publications

References 129 publications

Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes)

Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes)

Time- and Dose-Dependent Effects of Roundup on Human Embryonic and Placental Cells

Investigation of antiaromatase activity using hepatic microsomes of Nile tilapia (<i>Oreochromis niloticus</i>)

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