Arizonins, a new complex of antibiotics related to kalafungin. I. Taxonomy of the producing culture, fermentation and biological activity.

Abstract

The arizonins, a novel complex of antibiotics related to kalafungin, were discovered in the fermentation broth of Actinoplanes sp. AB660D-122.Comparative taxonomic studies indicated that the culture is a new species and therefore has been designated Actinoplanes arizonaensis sp. nov. Twomembersof the complex, arizonins Al and Bl, exhibit moderate to potent in vitro antimicrobial activity against pathogenic strains of Gram-positive bacteria. The arizonins were discovered while screening actinomycetes for new antimicrobial agents. Comparison of the producing culture to similar actinoplanetes revealed that it is a new memberof the genus Actinoplanes and has been namedActinoplanes arizonaensis sp. nov. strain AB660D-122.This paper describes the taxonomy of the producing culture and the fermentation and biological activity of the antibiotic. Portions of this work were described previously^. A companion paper has been published detailing the isolation and characterization of the arizonins including their relationship to kalafungin2). Materials and Methods Microorganisms The culture that produces the arizonins was isolated from a soil sample collected near Tuba City,

Pyranonaphthoquinone antibiotics—isolation, structure and biological activity

“…Arizonins A1 57 and B1 58 exhibit moderate activity against pathogenic strains of gram-positive bacteria, 88,89 however no activity against fungi or gram-negative bacteria was observed.…”