Aripiprazole-Induced Hyponatremia

Persistent Hiccups Associated With Switching From Risperidone to Aripiprazole in a Schizophrenic Patient With Cerebral Palsy

“…In terms of diverse 5-HT 2A Yantagonist binding affinities (eg, risperidone 9 clozapine 9 aripiprazole X quetiapine), 15 this can explain why quetiapine successfully resolved aripiprazole-induced hiccups in previously reported cases. 4,5 Nevertheless, this could not explain hiccups resolved with risperidone in our case. A partial agonist for aripiprazole at 5-HT 1A receptors might provide a reasonable explanation in the pathophysiology of hiccups because of the relatively high 5-HT 1A receptor binding affinities (aripiprazole X risperidone 9 clozapine 9 quetiapine).…”

“…6 The first case of aripiprazole-induced hiccups was reported by Behere et al, 4 in which a 69-year-old man with a history of bipolar affective disorder developed hyponatremia complicated by persistent hiccups within 2 days of starting aripiprazole 10 mg/d in addition to sodium valproate 1000 mg/d. Hiccups subsided with sodium level correction after discontinuing aripiprazole 1 week later.…”

Syndrome of inappropriate antidiuretic hormone associated with aripiprazole

“…Four other cases of possible aripiprazole-related hyponatremia have been reported in the literature. 22,[27][28][29] In two of these cases, hyponatremia occurred within days of aripiprazole dosage titration to 20 mg per day; in two cases, the patient was reported to be receiving other psychotropic medications that have been associated with SIADH. Our patient was also prescribed bupropion hydrochloride 150 mg twice daily and a high but stable dose of sertraline (300 mg per day).…”

Comment on Aripiprazole-Associated Hiccups

“…In both reported cases, hiccups reoccurred after rechallenge of aripiprazole. Behere et al 4 also described aripiprazole-induced hiccups which is associated with hyponatremia. On the other hand, Ray et al 5 and Silverman et al 1 have given no information about whether they tested hyponatremia.…”

“…On the other hand, Ray et al 5 and Silverman et al 1 have given no information about whether they tested hyponatremia. So we have 2 cases with aripiprazoleinduced hiccups concomitant with hyponatremia, 3,4 and 2 cases with aripiprazole-induced hiccups without information about hyponatremia. 1,5 In rest of the cases, there was no hyponatremia reported.…”