Syndrome of inappropriate antidiuretic hormone associated with aripiprazole

Abstract

A 65-year-old man developed severe hyponatremia after an aripiprazole dosage increase. Hyponatremia resolved promptly with the discontinuation of aripiprazole. After discharge from the hospital, the patient inadvertently received aripiprazole again and was subsequently readmitted with another episode of severe hyponatremia.

Aripiprazole-related hyponatremia and consequent valproic acid–related hyperammonemia in one patient

“…Our patient had aripiprazole-related hyponatremia which was likely due to serotonin-mediated syndrome of inappropriate antidiuretic hormone (Yam et al, 2013). There might be a connection between these two metabolic abnormalities.…”

“…Ming-Wei Lin 1,2 , Chieh Chang 2 , Chin-Bin Yeh 2 , Yueh-Ming Tai 1,2 , Hsin-An Chang 2,3 , Yu-Chen Kao 2,3,4 and Nian-Sheng Tzeng 2,4 To the Editor Aripiprazole-related hyponatremia and valproic acid (VPA)-related hyperammonemia have been reported (Vazquez et al, 2014;Yam et al, 2013), but a possible connection between the two has rarely been discussed. Herein, we report a case with both aripiprazolerelated hyponatremia and VPA-related hyperammonemia.…”

Hyponatremia and Psychotropic Drugs

“…There are currently presentations for oral, parenteral and prolonged release treatment. Literature collects cases of aripiprazole-induced hyponatremia both in patients who developed the symptoms at the start of treatment [15] and in increasing the dose [26], improving in all of them the clinical symptoms with interruption of treatment and water restriction.…”

Recognition and treatment of hyponatremia in psychiatric practice: Analysis of the frequency and report of case series

“…Osobe sa psihijatrijskim poremećajima predstavljaju grupu pacijenata u riziku od nastanka hiponatremije, pre svega zbog osobina pojedinih psihofarmaka, a zatim i usled određenih psihopatoloških fenomena (primarna polidipsija). Psihofarmaci, najpre antidepresivi (triciklični antidepresivi (TCA) -amitriptilin; selektivni inhi-bitori preuzimanja serotonina (SSRI) -citalopram, escitalopram, paroksetin; antidepresivi iz grupe NaSSA -mirtazapin), zatim antikonvulzivi (karbamazepin, fenitoin, valproat, lamotrigin) i antipsihotici (fenotiazini, haloperidol, risperidon, kvetijapin, olanzapin, aripiprazol, klozapin) povezani su sa rizikom od nastanka hiponatremije posredstvom mehanizama koji dovode do sindroma neadekvatnog lučenja antidiuretskog hormona (SIADH) [1,2,4,[6][7][8][9][10][11][12] . Sa druge strane, sindrom preteranog uzimanja tečnosti, odnosno intoksikacija vodom, koja je relativno čest psihopatološki fenomen udružen sa psihotičnim poremećajima, može dovesti do intoksikacije vodom i dilucione hiponatremije [4,[13][14][15] .…”