Arı Sütünün İnsan ve Hayvan Sağlığında Fonksiyonel Gıda Olarak Kullanımı

Stranț, Mirela; Yücel, Banu; Topal, Erkan; Puscasu, Ana Maria; Mărgăoan, Rodica; Varadi, Alina

doi:10.29185/hayuretim.513449

Cited by 6 publications

(2 citation statements)

References 76 publications

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“…Based on previous studies, the dose gradient of RJ was set to 100, 200, 400, and 800 mg kg -1 d -1 . [24,26] The intake of RPXT per rat was 500 mg kg -1 d -1 . [25] Before each feeding experiment, RJ or RPXT was diluted with sterile water to prepare different doses for intragastric administration (i.g.)…”

Section: Dosage Informationmentioning

confidence: 99%

Dose‐Dependent Effects of Royal Jelly on Estrogen‐ and Progesterone‐Induced Mammary Gland Hyperplasia in Rats

Liu

Wang

et al. 2022

Molecular Nutrition Food Res

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Scope: Royal jelly (RJ) has a wide range of biological functions, its effect on hyperplasia of the mammary gland (HMG) in mammals is unclear. This study aims to investigate the effect of RJ on HMG and the dose-response relationship of RJ in the treatment of HMG. Methods and Results: HMG rats are induced by intramuscular injection of estrogen (E2) and progesterone, and are treated with different doses of RJ (100, 200, 400, and 800 mg kg -1 d -1 ). As a result, RJ improves the expansion of acinar and breast tissue ducts, particularly at 100 and 800 mg kg -1 d -1 . These two doses also inhibit serum E2 and prolactin (PRL) secretion and increase serum progesterone secretion and the expression of estrogen receptor (ER)-𝜷 in the breast tissue. In addition, 800 mg kg -1 d -1 decrease and increase the mRNA expression of, respectively, hypothalamic gonadotropin-releasing hormone (GnRH) and pituitary GnRH receptors (GnRH-R). The lowest dosage (100 mg kg -1 d -1 ) increases GnRH-R mRNA expression as well. However, the effects of 200 and 400 mg kg -1 d -1 RJ on the reproductive parameters of HMG are not significant, implying a dose-dependent effect. Conclusion: RJ regulates endocrine dyscrasia in HMG rats and improves the breast tissue structure, indicating its potential in the prevention and treatment on HMG.

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Section: Dosage Informationmentioning

confidence: 99%

Dose‐Dependent Effects of Royal Jelly on Estrogen‐ and Progesterone‐Induced Mammary Gland Hyperplasia in Rats

Liu

Wang

et al. 2022

Molecular Nutrition Food Res

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“…Proteins (MRJPs) and trans-10-hydroxy-2-decenoic acid (10-HDAs) are the main active compounds known to be present in royal jelly (Ali and Kunugi, 2020a). There are many in vitro and in vivo studies on the biological activities and bioactive components of royal jelly (Pavel et al, 2011;Khazaei et al, 2018;Strant et al, 2019;Shakib Khoob et al, 2022). In these studies, royal jelly has been shown to have antioxidant (Ghanbari et al, 2016), antimicrobial (Park et al, 2019), antibacterial (Fratini et al, 2016), anti-inflammatory (Chen et al, 2016), anticancer (Miyata and Sakai, 2018), antitumor (Albalawi et al, 2022), anti-aging (Ali and Kunugi, 2020b) effects.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Yield and Some Quality Features of Royal Jelly Harvested from Honeybee Colonies Fed with Food Substitutes

Oskay

BAYRAK

2022

Hayvansal Üretim

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Objective: In several nations, royal jelly is employed in apitherapy, healthful foods, and cosmetics. Scientists and beekeepers are attempting to improve the production and quality of royal jelly extracted from honeybee hives. This research studied the impact of honey and pollen substitute feeding on royal jelly production efficiency. In addition, analyses were conducted to determine the differences between fed and unfed groups in terms of 10-hydroxy-2-deconoic acid (10-HDA), protein and pH characteristics, pollen, and honey substitute. Material and Methods: In this research, the influence of honey and pollen substitute feeding on royal jelly production was examined using the ANOVA test for multiple comparisons by forming 3 different groups and conducting 2 replications. Also, features of the 10- hydroxy-2-deconoic acid (10-HDA), protein and pH of the royal jelly was analyzed for understanding differences among the non-feeding pollen and honey substitution feeding groups. Results: The average RJ yield per queen cup for non-feeding colonies (Group A) was 420 mg, while the content of 10-HAD, protein and pH were 2.40%, 14.06% and 4.20%, respectively. For the colonies fed with sugar syrup (Group B), these values were 470 mg, 2.51%, 12.88%, 4.25 and for the colonies fed with sugar syrup+pollen substitute (Group C) 530 mg, 4.05%, 13.13% and 4.18. The statistical test and contents analysis highlighted the impact of substitution feeding on average yield amounts and 10-HDA. According to the results of the research, average RJ amounts in queen cell cup was significantly different in three honey bee colonies feeding groups (p

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Influence of Honey bee Nutritive Jelly Type and Dilution on its Bactericidal Effect on Melissococcus plutonius, the Etiological Agent of European Foulbrood

et al. 2022

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To defend themselves against pathogenic microorganisms, honey bees resort to social immunity mechanisms, such as the secretion of antibiotic compounds in the jelly they feed to their larvae. Whereas the bactericidal activity of jelly fed to queen larvae is well studied, little is known about the bioactivity of compositionally different jelly fed to worker larvae. However, the numerous worker larvae are likely to drive the spread of the microorganism and influence its virulence and pathogenesis. Diluted jelly or extracts are mostly used for jelly bioactivity tests, which may bias the evaluation of the pathogen’s resistance and virulence. Here, we compared the bactericidal effect of pure and diluted jellies destined for queen and worker larvae on Melissococcus plutonius, the etiological agent of the European foulbrood (EFB) disease of honey bees, and on a secondary invader bacteria, Enterococcus faecalis. We tested three strains of M. plutonius with varying virulence to investigate the association between resistance to antibacterial compounds and virulence. The resistance of the bacteria varied but was not strictly correlated with their virulence and was lower in pure than in diluted jelly. Resistance differed according to whether the jelly was destined for queen or worker larvae, with some strains being more resistant to queen jelly and others to worker jelly. Our results provide a biologically realistic assessment of host defenses via nutritive jelly and contribute to a better understanding of the ecology of M. plutonius and of secondary invaders bacteria in the honey bee colony environment, thus shedding light on the selective forces affecting their virulence and on their role in EFB pathogenesis.

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Arı Sütünün İnsan ve Hayvan Sağlığında Fonksiyonel Gıda Olarak Kullanımı

Cited by 6 publications

References 76 publications

Dose‐Dependent Effects of Royal Jelly on Estrogen‐ and Progesterone‐Induced Mammary Gland Hyperplasia in Rats

Dose‐Dependent Effects of Royal Jelly on Estrogen‐ and Progesterone‐Induced Mammary Gland Hyperplasia in Rats

Investigation of Yield and Some Quality Features of Royal Jelly Harvested from Honeybee Colonies Fed with Food Substitutes

Influence of Honey bee Nutritive Jelly Type and Dilution on its Bactericidal Effect on Melissococcus plutonius, the Etiological Agent of European Foulbrood

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