ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients

Xie, Yangyang; Gao, Li; Xu, Chunhui; Chu, Liming; Gao, Lei; Wu, Ruichi; Liu, Yu; Liu, Ting; Sun, Xiao Jian; Ren, Ruibao; Tang, Jingyan; Zheng, Yi; Zhou, Yong; Shen, Shuhong

doi:10.3324/haematol.2018.210286

Cited by 22 publications

(16 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, RhoA activity has been linked to erythroid differentiation since an overexpression of a dominant-negative form of RhoA led to anemia. This phenotype mimicked the knockdown of the RhoA specific guanine nucleotide exchange factor arhgef12 that could be rescued by a co-injection of a constitutive active form of RhoA (Q63L) [106].…”

Section: Rhoa In Pathology and Regenerationmentioning

confidence: 75%

See 1 more Smart Citation

Rho GTPases Signaling in Zebrafish Development and Disease

Boueid

Mikdache

Lesport

et al. 2020

Cells

View full text Add to dashboard Cite

Cells encounter countless external cues and the specificity of their responses is translated through a myriad of tightly regulated intracellular signals. For this, Rho GTPases play a central role and transduce signals that contribute to fundamental cell dynamic and survival events. Here, we review our knowledge on how zebrafish helped us understand the role of some of these proteins in a multitude of in vivo cellular behaviors. Zebrafish studies offer a unique opportunity to explore the role and more specifically the spatial and temporal dynamic of Rho GTPases activities within a complex environment at a level of details unachievable in any other vertebrate organism.

show abstract

Section: Rhoa In Pathology and Regenerationmentioning

confidence: 75%

“…RhoA FRET biosensor [18,113] RhoAT19N DN form of RhoA [98] RhoAV14 CA form of RhoA [6,98] WT-RhoA mRNA WT RhoA expression [6] RhoA Q63L mRNA CA form of RhoA [106] Table 3. Available morpholinos (MOs) and tools to activate or inhibit Rho GTPases activity in zebrafish.…”

Section: Rhoa Biosensormentioning

confidence: 99%

Rho GTPases Signaling in Zebrafish Development and Disease

Boueid

Mikdache

Lesport

et al. 2020

Cells

View full text Add to dashboard Cite

show abstract

“…The encoded protein may form a complex with G protein and mediate several cellular processes, suggesting that G protein signaling may be fashioned within the context of a cell-sex influence. Recently, it has been shown bioinformatically that ARHGEF12 is part of a network of genes and miRNAs that regulates axon regeneration [ 132 ] while in zebrafish the knockout of Arhgef12 resulted in a defective erythropoiesis [ 133 ]. No correlations between ARHGEF12 and sex are reported in literature until now.…”

Section: Discussionmentioning

confidence: 99%

Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells

Bianconi

Casadei

Frabetti

et al. 2020

Genes

View full text Add to dashboard Cite

In humans, sexual dimorphism can manifest in many ways and it is widely studied in several knowledge fields. It is increasing the evidence that also cells differ according to sex, a correlation still little studied and poorly considered when cells are used in scientific research. Specifically, our interest is on the sex-related dimorphism on the human mesenchymal stem cells (hMSCs) transcriptome. A systematic meta-analysis of hMSC microarrays was performed by using the Transcriptome Mapper (TRAM) software. This bioinformatic tool was used to integrate and normalize datasets from multiple sources and allowed us to highlight chromosomal segments and genes differently expressed in hMSCs derived from adipose tissue (hADSCs) of male and female donors. Chromosomal segments and differentially expressed genes in male and female hADSCs resulted to be related to several processes as inflammation, adipogenic and neurogenic differentiation and cell communication. Obtained results lead us to hypothesize that the donor sex of hADSCs is a variable influencing a wide range of stem cell biologic processes. We believe that it should be considered in biologic research and stem cell therapy.

show abstract

“…CASP4, a member of the in ammatory caspases, has been shown to promote the proliferation of many kinds of cancer cells [24]. Xie et al found a novel SNP of ARHGEF12 that may involve ARHGEF12-RhoA-p38 signaling in erythroid regeneration in ALL patients after chemotherapy [25]. Recent advances have demonstrated that kinetochore-associated proteins are upregulated and serve signi cant roles in the carcinogenesis of numerous types of cancer.…”

Section: Discussionmentioning

confidence: 99%

A plasma membrane protein based prognostic model in clear cell renal cell carcinoma

Liu

Fang

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Renal cell cacinoma (RCC) accounts for 3% of human cancers, and clear cell renal cell carcinoma (ccRCC) is the most common pathological type of RCC. Cell surface proteins have been shown to play an important role in the occurrence and progression of various cancers. In this study, we focused on plasma membrane proteins (PMPs), to explore their potential value in ccRCC. Methods The PMPs expression profiles and ccRCC patients’ clinical information were downloaded from TCGA database. Through a series of bioinformatic methods, we established a plasma membrane proteins prognostic model. Results Multivariate cox regression analysis and area under receiver operating characteristic curve indicated that this model was an effective independent predictor of ccRCC clinical outcomes. Combined with other two clinical characteristics, a nomogram was constructed to predict patient survival at 1, 3, and 5 years. Conclusions Our study is the first to explore the prognostic value of plasma membrane proteins in clear cell renal cell carcinoma. We hope our work could provide a new viewpoint for ccRCC prognosis and drawn people’s attention to plasma membrane proteins in clear cell renal cell carcinoma.

show abstract

ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients

Cited by 22 publications

References 46 publications

Rho GTPases Signaling in Zebrafish Development and Disease

Rho GTPases Signaling in Zebrafish Development and Disease

Sex-Specific Transcriptome Differences in Human Adipose Mesenchymal Stem Cells

A plasma membrane protein based prognostic model in clear cell renal cell carcinoma

Contact Info

Product

Resources

About