Argyrophilic nucleolar organizer regions (AgNORs) in odontogenic myxoma (OM) and ameloblastic fibroma (AF)

Martins, Cristiane Nunes; Carvalho, Yasmin Rodarte; Carmo, María Auxiliadora Vieira do

doi:10.1034/j.1600-0714.2001.030008489.x

Cited by 16 publications

(11 citation statements)

References 10 publications

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“…The AgNORs count in ameloblastic carcinoma was twice the count in ameloblastoma (Figs. 4,5). The NORs counted in ameloblastoma was 168 in 100 cells and in ameloblastic carcinoma, the count was 342 in 100 cells.…”

Section: Case Reportmentioning

confidence: 99%

“…Some researchers have suggested that the use of special stains such as Silver staining nucleolar organizer regions may be used to differentiate between various odontogenic cysts and tumors [5][6][7]. Recent research works utilizing immunohistochemical methods targeting different tissue markers have suggested a variation in expression patterns of these markers in ameloblastoma and ameloblastic carcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Nucleolar Organizing Regions and α-Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma

Kamath

Monappa

Shetty

et al. 2010

Head and Neck Pathol

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Ameloblastic carcinoma is a rare lesion of odontogenic origin. It is defined as a malignant epithelial odontogenic tumor that histologically has retained the features of ameloblastic differentiation and also exhibits cytologic features of malignancy, like atypia and mitotic activity. Although this lesion represents a separate entity, differentiating it from ameloblastoma has been often challenging to pathologists. In this case study reporting a case of ameloblastic carcinoma, we have attempted to verify the previous findings on the use of Argyrophilic nucleolar organizing regions (AgNORs) and immunohistochemical staining for the alpha-smooth muscle actin (alpha-SMA) in differentiating ameloblastic carcinoma from ameloblastoma. It was observed that AgNORs was found to be almost twice in ameloblastic carcinoma as it was in ameloblastoma. A difference between the two lesions in the pattern of expression of alpha-SMA was also observed, with alpha-SMA being expressed in the odontogenic epithelium and the stroma of ameloblastic carcinoma whereas, in the case of ameloblastoma, it was found only in the stromal part. These findings suggest that AgNORs and alpha-SMA expression may be used as adjuncts to the routine histopathologic examination to differentiate ameloblastic carcinoma and ameloblastoma.

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Section: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nucleolar Organizing Regions and α-Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma

Kamath

Monappa

Shetty

et al. 2010

Head and Neck Pathol

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“…Some authors report that the risk of recurrence is greater as the myxoma is not encapsulated and its myxomatous tissue infiltrates the surrounding bony tissue without causing immediate destruction than to the cell proliferative index which was relatively low [22,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…Prosthetic reconstruction in maxillary lesions is highly advisable due to low postoperative morbidity and almost immediate phonetic and masticatory function. Furthermore prosthetic reconstruction by an obturator allows direct visualization of the primary site for recurrence detection [25].…”

Section: Introductionmentioning

confidence: 99%

Odontogenic Myxoma of Maxilla: Conservative or Radical Surgery?

Hamama¹,

Khalfi²,

Kamal³

et al. 2018

Int Arch Oral Maxillofac Surg

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mor, incidence rate is approximately 0.07 new cases per million people per year [7,8].All reports generally agree that the tumour frequently presents in the second or third decades of life [8][9][10].Most common clinical characteristics of odontogenic myxoma are swelling of the jaws with only few patients complaining of pain, paraesthesia and ulceration, 28% for pain and 56% for swelling [11].Several studies indicating that there is a higher rate of tumour incidence in the mandible than the maxilla [12][13][14][15], and almost occurring in the premolar and molar region of both jaws and rarely crosses the midline [12,16,17].Cortical expansion and perforation are common findings; however, maxillary myxomas often extend into the sinus [18]. The adequate management of Odontogenic myxoma (OM) is a challenging problem against the high risk of recurrence.The aim of this paper is to report a case of odontogenic myxoma that affected the left maxilla focusing especially on surgical management. Case ReportA 42-year-old female was referred to our department with a complaint of a growing swelling in the area of the canin and premolar molar in his left maxilla that had been noticed a few weeks before. Upon admission, she noticed a swelling measuring about the size of a peanut in the gingiva of upper premolar tooth. That lesion had been excised by a dentist and the histopathologist con- AbstractOdontogenic myxoma (OM) is a benign, locally invasive and aggressive, non-metastasizing neoplasm of the jaw bones. This article presents a rare case of odontogenic myxoma occurring in the maxilla of a 42-year-old female patient with review of the literature emphasizing a huge controversy regarding the surgical management.

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“…The NOR are associated with acidic argyrophilic non-histonic proteins which can be viewed through the AgNOR technique 20,24 . Studies have applied this technique as a useful method to evaluate the differences among cellular proliferation indexes in non-neoplastic reactive lesions, as well as in benign or malignant neoplasms 3,9,15,17,23 .…”

Section: Introductionmentioning

confidence: 99%

Cellular proliferation markers in peripheral and central fibromas: a comparative study

et al. 2013

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Objective:To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods:Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in 8 cases of peripheral ossifying fibroma (PEOF) and 7 cases of ossifying fibroma (OsF). The Kruskal-Wallis and Mann-Whitney tests were used for the statistical analyses. Results:Mesenchymal component of the central lesions presented a higher mean number of AgNOR per nucleus and PCNA index than did the peripheral lesions (P≤0.05). The mean number of AgNOR per nucleus in the epithelial component proved to be higher in the OdF than in the POF (P≤0.05). The mesenchymal and epithelial components presented similar mean numbers of AgNOR per nucleus and PCNA index in the OdF, as well as a similar mean number of AgNOR per nucleus in the POF.Conclusions:The mesenchymal component may well play a role in the differences between the biological behaviour of the central lesions as compared to the peripheral lesions. Moreover, considering that the epithelial and mesenchymal components in odontogenic fibromas presented a similar proliferation index, more research is warranted to understand the true role of the epithelial components, which are believed to be inactive in nature, as well as in the development and biological behaviour of these lesions.

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Argyrophilic nucleolar organizer regions (AgNORs) in odontogenic myxoma (OM) and ameloblastic fibroma (AF)

Cited by 16 publications

References 10 publications

Nucleolar Organizing Regions and α-Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma

Nucleolar Organizing Regions and α-Smooth Muscle Actin Expression in a Case of Ameloblastic Carcinoma

Odontogenic Myxoma of Maxilla: Conservative or Radical Surgery?

Cellular proliferation markers in peripheral and central fibromas: a comparative study

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