Argon Laser Retinal Lesions Evaluated In Vivo by Optical Coherence Tomography

Toth, Cynthia A.; Birngruber, Reginald; Boppart, Stephen A.; Hee, Michael R.; Fujimoto, James G.; DiCarlo, Cheryl Dawn; Swanson, Eric A.; Cain, Clarence P.; Narayan, Drew G.; Noojin, Gary D.; Roach, William P.

doi:10.1016/s0002-9394(14)71035-9

Cited by 65 publications

(36 citation statements)

References 15 publications

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“…26,29,30 The thinning observed in the RNFL inferior quadrant in patients with OH confirms previous observations, 31 although with a different percentage incidence that may be owing to the analysis method used. [32][33][34][35] This localized thinning of the RNFL might be an early sign of glaucoma 36 before any signs of optic nerve disorders or visual field impairment appear.…”

Section: Discussionsupporting

confidence: 85%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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Purpose To study in ocular hypertension (OH) the retinal nerve fibre layer (RNFL) with optical coherence tomography (OCT) and the neuronal function with frequency-doubling technology (FDT) to assess which of the two methods was more sensitive in detecting early glaucomatous damage. Furthermore, a colour Doppler imaging (CDI) of the optic nerve was carried out to highlight any correlation with RNFL thickness and FDT abnormality. Materials and methods We enrolled 28 ocular hypertensive patients who underwent OCT of the RNFL and FDT. Moreover, we performed a CDI of the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCAs). Results The patients with OH following OCT revealed a significant thinning in the RNFL as compared to the control group only in the inferior quadrant: 122.250714.091 vs 131.750710.729 lm (Po0.045). As regards FDT, there was a significant difference between the two groups only for pattern standard deviation (PSD): 3.87371.488 vs 1.93870.704 dB (Po0.044). In OH and in the control group, CDI resistance index (RI) in the OA was 0.76870.012 vs 0.74570.019 (Po0.022), in the CRA was 0.6670.012 vs 0.64570.019 (Po0.032), and in PCAs was 0.67370.039 vs 0.62270.012 (Po0.037). The OCT had a sensitivity of 83% but only in the inferior RNFL quadrant. The FDT-PSD revealed a sensitivity of 85%. Conclusions Both FDT and OCT detect early glaucomatous damage with a slightly superior sensitivity of FDT vs OCT. The CDI measurements suggest that circulatory abnormalities may have a role in the development of OCT and FDT damage.

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Section: Discussionsupporting

confidence: 85%

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Cellini

Bernabini

Carbonelli

et al. 2006

Eye

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“…51,52 Retinal laser scars appear as areas of increased reflectivity of the outer retinal layers with surrounding areas of lower reflectivity. 53 …”

Section: Macular Oedemamentioning

confidence: 99%

Optical coherence tomography—a review of the principles and contemporary uses in retinal investigation

Thomas

Duguid

2004

Eye

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“…The use of OCT in an interventional procedure was first demonstrated by the OCT image-guided placement and assessment of retinal laser lesions in the in vivo primate eye [75,76]. These studies examined the dynamic evolution of retinal lesions from continuous wave lasers, and from nanosecond, picosecond, and femtosecond pulses at visible wavelengths (514-580 nm).…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography: Feasibility for Basic Research and Image-guided Surgery of Breast Cancer

Boppart

Luo

Marks

et al. 2004

Breast Cancer Res Treat

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SummaryDiagnostic trends in medicine are being directed toward cellular and molecular processes, where treatment regimens are more amenable for cure. Optical imaging is capable of performing cellular and molecular imaging using the short wavelengths and spectroscopic properties of light. Diffuse optical tomography is an optical imaging technique that has been pursued as an alternative to X-ray mammography. While this technique permits noninvasive optical imaging of the whole breast, to date it is incapable of resolving features at the cellular level. Optical coherence tomography (OCT) is an emerging high-resolution biomedical imaging technology that for larger and undifferentiated cells can perform cellular-level imaging at the expense of imaging depth. OCT performs optical ranging in tissue and is analogous to ultrasound except reflections of near-infrared light are detected rather than sound. In this paper, an overview of the OCT technology is provided, followed by images demonstrating the feasibility of using OCT to image cellular features indicative of breast cancer. OCT images of a well-established carcinogen-induced rat mammary tumor model were acquired. Images from this common experimental model show strong correlation with corresponding histopathology. These results illustrate the potential of OCT for a wide range of basic research studies and for intra-operative image-guidance to identify foci of tumor cells within surgical margins during the surgical treatment of breast cancer.

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Argon Laser Retinal Lesions Evaluated In Vivo by Optical Coherence Tomography

Cited by 65 publications

References 15 publications

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Optical coherence tomography, frequency-doubling technology, and colour Doppler imaging in ocular hypertension

Optical coherence tomography—a review of the principles and contemporary uses in retinal investigation

Optical Coherence Tomography: Feasibility for Basic Research and Image-guided Surgery of Breast Cancer

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