Optical coherence tomography—a review of the principles and contemporary uses in retinal investigation

Thomas, Dhanes; Duguid, Graham

doi:10.1038/sj.eye.6700729

Cited by 90 publications

(65 citation statements)

References 58 publications

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“…[1][2][3] Traditionally, this has been performed using a commercially available time-domain model (OCT-3, Carl Zeiss, Meditec, Inc., Dublin, CA). Numerous advances in the understanding of retinal diseases are still being made using this model.…”

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confidence: 99%

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

et al. 2006

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Purpose: To introduce and examine the utility of a retinal imaging technique using high-speed optical coherence tomography (OCT) for creating a more complete retinal structural map to aid in the evaluation of patients with macular pathology.Design: Prospective observational case series. Participants: Five patients with a variety of macular pathologies. Methods: Patients were imaged with a Fourier-domain high-speed high-resolution OCT system built at our institution. A sweeping serial OCT B-scan of the macula was acquired to create a detailed retinal structural map. The data were then used to make individual clinical observations.Results: Rapid serial OCT B-scans produced detailed macular maps for all 5 patients. Diagnoses of imaged patients included macular hole, lamellar macular hole, regressed macular hole or macular microhole, choroidal neovascular membrane (CNV) from age-related macular degeneration, and CNV from presumed ocular histoplasmosis syndrome. Reconstructed B-scans and C-scans are shown for selected patients to illustrate the additional perspectives gained by obtaining a detailed retinal map.Conclusions: Rapid serial Fourier-domain OCT B-scanning can be used to create a detailed retinal structural map. This technique provides additional information that can be missed on single OCT images and provides an accurate way to image large or complex lesions, and allows B-scan and C-scan reconstructions to be made that provide additional perspectives into retinal structures that may be missed using traditional imaging methods.

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Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

et al. 2006

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“…Traditional optical coherence tomography (OCT) is a time domain OCT (TD-OCT), [1][2][3][4] where depth informations of the retina are obtained after a longitudinal translation in time of a reference arm. Good reproducibility of retinal thickness measurements by Stratus OCT (Carl Zeiss Meditec, USA) has been shown.…”

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confidence: 99%

Comparison of time domain Stratus OCT and spectral domain SLO/OCT for assessment of macular thickness and volume

Forte

Cennamo

Finelli

et al. 2008

Eye

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“…W ith the ability to visualize the layered structure of the retina, [1][2][3][4][5][6] optical coherence tomography (OCT) has improved the diagnosis and management of many ocular diseases. One of its principal features is the quantitation of macular thickness, an important indicator of the severity of different pathologic conditions.…”

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confidence: 99%

Artifacts in Automatic Retinal Segmentation Using Different Optical Coherence Tomography Instruments

Giani¹,

Cigada²,

Esmaili³

et al. 2010

Retina

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Purpose:The purpose of this study was to compare and evaluate artifact errors in automatic inner and outer retinal boundary detection produced by different time-domain and spectral-domain optical coherence tomography (OCT) instruments.Methods: Normal and pathologic eyes were imaged by six different OCT devices. For each instrument, standard analysis protocols were used for macular thickness evaluation. Error frequencies, defined as the percentage of examinations affected by at least one error in retinal segmentation (EF-exam) and the percentage of total errors per total B-scans, were assessed for each instrument. In addition, inner versus outer retinal boundary delimitation and central (1,000 m) versus noncentral location of errors were studied.Results: The study population of the EF-exam for all instruments was 25.8%. The EF-exam of normal eyes was 6.9%, whereas in all pathologic eyes, it was 32.7% (P Ͻ 0.0001). The EF-exam was highest in eyes with macular holes, 83.3%, followed by epiretinal membrane with cystoid macular edema, 66.6%, and neovascular age-related macular degeneration, 50.3%. The different OCT instruments produced different EF-exam values (P Ͻ 0.0001). The Zeiss Stratus produced the highest percentage of total errors per total B-scans compared with the other OCT systems, and this was statistically significant for all devices (P Յ 0.005) except the Optovue RTvue-100 (P ϭ 0.165).Conclusion: Spectral-domain OCT instruments reduce, but do not eliminate, errors in retinal segmentation. Moreover, accurate segmentation is lower in pathologic eyes compared with normal eyes for all instruments. The important differences in EF among the instruments studied are probably attributable to analysis algorithms used to set retinal inner and outer boundaries. Manual adjustments of retinal segmentations could reduce errors, but it will be important to evaluate interoperator variability.RETINA 30:607-616, 2010

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Optical coherence tomography—a review of the principles and contemporary uses in retinal investigation

Cited by 90 publications

References 58 publications

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

Comparison of time domain Stratus OCT and spectral domain SLO/OCT for assessment of macular thickness and volume

Artifacts in Automatic Retinal Segmentation Using Different Optical Coherence Tomography Instruments

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