Argiria cutánea localizada. A propósito de 2 casos

Garcías-Ladaria, J.; Hernández-Bel, P.; Torregrosa-Calatayud, J.L.; Martínez‐Aparicio, A.

doi:10.1016/j.ad.2012.03.013

Cited by 5 publications

(7 citation statements)

References 8 publications

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“…This results in macular lesions or spots-clusters, confined to where the silver impregnation occurred and with coherent morphology, whose color, compared to GA's, tends to be darker, sometimes almost black [8,73,[81][82][83]. Patients most commonly present with complaints of asymptomatic lesions in a site of previous trauma, cautery with silver devices, or prolonged contact with silver-containing objects, creams, or solutions, as it occurs in the hands and forearms of silver-handling workers [2,75,81,82,[84][85][86][87].…”

Section: Localized Argyriamentioning

confidence: 99%

“…Discoloration of the leg over a silver-coated megaprosthesis used for distal femoral osteosarcoma (E). Reprinted from (A)- [88], (B)- [89], (C)- [87], (D)- [73] and (E)- [90]. Amalgam tattoo (Figure 4) is probably the most common form of LA [91][92][93].…”

Section: Figurementioning

confidence: 99%

“…Iatrogenic, topical, and/or systemic [130] Intractable diplopia (use of silver nitrate-coated soft lenses) Iatrogenic, topical [199] Antiseptic and astringent properties (application of silver-containing vasoconstricting nose drops) Non-medical, systemic (oral intake) [7,91] The timespan for the onset of the pigmentation might vary from days to several years, and it then becomes ever lasting, making the diagnosis of argyria not discardable regardless of the amount of time passed since exposition and first-time pigmentation observation [8,81,83,87,134,164,165,188,222,244]. These should prompt a thorough anamnesis to ascertain if there is any kind of pathological or toxicological justification for these alterations and to establish a differential diagnosis (Table 2).…”

Section: Treatment Cause Referencesmentioning

confidence: 99%

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Clinical and Forensic Aspects of the Different Subtypes of Argyria

Mota

Dinis-Oliveira

2021

JCM

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Argyria encompasses the different cosmetic alterations that can develop if enough silver particles deposit in a specific tissue, typically in the skin, ranging from localized dark-blue macules to a generalized slate-gray/bluish tinge following systemic absorption. This work aims to fully review the state of the art regarding pathophysiology, diagnosis, treatment, and relevant clinical and forensic features of argyria. Argyria has been diagnosed in a wide range of ages, both sexes and varied ethnicities, with no known individual predisposing factors. Ultraviolet radiation with subsequence increases of melanin production aggravates the discoloration due to a reduction in the silver deposits. Physical examination and silver exposure in the anamnesis can be highly suggestive of the diagnosis, but a histopathological analysis with Energy-Dispersive X-ray Spectroscopy is required to unequivocally determine the discoloration etiology. Safe and effective treatment has only been accomplished with laser techniques, though only a few cases have been reported and with limited follow-up time. In conclusion, argyria typically has an occupational or iatrogenic etiology. It should be suspected when a patient presents with typical skin or eye lesions. A seemingly viable treatment modality, with laser technology, is finally within the horizon.

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Section: Localized Argyriamentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Treatment Cause Referencesmentioning

confidence: 99%

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Clinical and Forensic Aspects of the Different Subtypes of Argyria

Mota

Dinis-Oliveira

2021

JCM

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“…However, FFF requires sophisticated instruments and technical expertise, which were beyond the objectives of this study. The obtained information on the total Ag concentration in these products was considered sufficient since their associated adverse effects are of concern regardless of the form of Ag in the product (Chung et al 2010;Garcias-Ladaria et al 2013;McKenna et al 2003). …”

Section: Characterization Of Ag In the Nanoproductsmentioning

confidence: 99%

“…In general, people are exposed daily to very low levels of Ag, mainly in food and drinking water and, to a lesser extent in the air. Recently, Ag has become of increasing interest and concern because its accumulation from long-term exposure, such as from ingestion, inhalation, and direct dermal contact, is associated with a specific clinical condition called ''Argyria,'' an irreversible blue-gray pigmentation of the skin (Chung et al 2010;Garcias-Ladaria et al 2013;McKenna et al 2003). According to the environmental health and safety concerns, legislation for limiting the exposure of Ag, especially in the workplace (0.01 mg/m 3 ) and drinking water (0.1 mg/L), has been implemented (OSHA 2013;EPA 2012).…”

Section: Introductionmentioning

confidence: 99%

Determination of silver in personal care nanoproducts and effects on dermal exposure

et al. 2015

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Silver (Ag) is one of the widely used nanomaterials in cosmetics, personal care, and household products. This research aimed to investigate the Ag concentration contained in 20 commercial nanoproducts using a simple and reliable procedure. The exposure and adverse effects of a single topical application of Ag on the skin were also evaluated. Herein, we demonstrated that the technique of wet acid digestion, extraction and detection of Ag with graphite furnace absorption spectrometry were effective for any and all nanoproduct matrices. The Ag morphology was characterized by scanning and transmission electron microscopy equipped with energy-dispersive x-ray spectroscopy. Penetration of Ag was evaluated using a polyethersulfone (PES) membrane through a Franz cell and reconstructed human epidermis (RhE) tissue. A skin irritation test was performed on RhE, an acceptable in vitro model which was in compliance with OECD test guideline 439. The results showed that the initial Ag concentration in the tested nanoproducts ranged between 0.0058 and 94 lg/g. However, particulate Ag was only found in two products, both of a liquid formulation. Silver penetration through a PES membrane (0.12-53 % by weight) was weakly correlated with the initial Ag concentration in each sample, but more so to the product formulation. The liquid products demonstrated the highest percent of average Ag penetration, followed by the semi-solid and solid formulations, respectively. In contrast, neither any Ag diffusion from these products into the RhE tissue nor any irritation or toxicity was detected. This study suggests a screening method to evaluate the Ag level in products and their potential adverse effects on the skin that could be incorporated as a part of risk assessment for nanotechnology products.

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