Argan Oil Nanoemulsions as New Hydrophobic Drug-Loaded Delivery System for Transdermal Application

Lococo, David B.; Mora-Huertas, Claudia Elizabeth; Fessi, Hatem; Zaanoun, I.; Elaissari, Abdul Hamid

doi:10.1166/jbn.2012.1445

Cited by 14 publications

(8 citation statements)

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“…But in the case of zeta potential there was negative zeta potential for particles without and with Argan oil or Argan oil containing indomethacin (Table 2). Here, the zeta potential value of the particles without Argan oil and indomethacin was negative; this could be related also to the probable residual fatty acids from the synthesis of sorbitan esters (acid values of the surfactants, i.e., the quantity of free carboxylic acid groups in the surfactant) [14].…”

Section: Effect Of the Argan Oil Presencementioning

confidence: 85%

Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application

Badri

Miladi

Eddabra

et al. 2015

Journal of Nanomaterials

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The objective of this work is the preparation of nanocapsules which are intended for the treatment of rheumatoid arthritis (RA). We use Argan oil as vehicle of hydrophobic drugs such as indomethacin. Nanoprecipitation technique was used like a method for preparation of nanocapsules, where polycaprolactone, acetone, and Argan oil are used as polymer, solvent, and carrier, respectively. Primarily, investigation of Argan oil amount addition was performed; then systematic study to optimize the formulation was done. Nanocapsules containing indomethacin (loaded nanocapsules) and others without indomethacin (blank nanocapsules) were characterized by studying particles size, zeta potential, and encapsulation efficiency. It is shown that particle size ranged between 290 nm and 350 nm. The zeta potential values were negative (from −40 up to −50 mV) while encapsulation efficiency ranged between 65 and 75%.

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Section: Effect Of the Argan Oil Presencementioning

confidence: 85%

Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application

Badri

Miladi

Eddabra

et al. 2015

Journal of Nanomaterials

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“…[97] At the same time, they exhibit bioactivity, which can reduce transepidermal water loss. Their main advantage is the small size of the drops along with their large surface allowing for effective transport of active ingredients.…”

Section: The Application Of Argan Oil In Cosmeticsmentioning

confidence: 99%

The Properties and Application of Argan Oil in Cosmetology

Goik

Goik²,

Załęska

2019

Euro J Lipid Sci & Tech

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For the last few years there has been observed an interest and growing awareness of consumers regarding healthy diet, way of life, and body care. This leads to the design and creation of new products and cosmetic formulations with appropriate sensory characteristics and rheological properties, attractive in terms of nutritional values, and body care. Argan oil contains a high level of both oleic acid and linoleic acid, making it an excellent source of basic polyunsaturated fatty acids. Also, it is particularly rich in polyphenols and tocopherols that exhibit significant antioxidant activity. This paper presents a literature review of the properties of argan oil and their application. Argan oil is used in the food, pharmaceutical and cosmetics industries and supports the treatment of many diseases. Practical Applications: This work presents a wide review and discussion of the literature on the issues related to the use of argan oil in cosmetology and cosmetics industry based on its properties. This review work can be helpful for the cosmetics and food industry in creating new cosmetic recipes and food products (e.g., special‐purpose products) using argan oil as a base raw material. Argan oil contains a high level of both oleic acid and linoleic acid, making it an excellent source of basic polyunsaturated fatty acids. It is also particularly rich in polyphenols and tocopherols that exhibit significant antioxidant activity. This leads to the design and creation of new products and cosmetic formulations with appropriate sensory characteristics and rheological properties, attractive in terms of nutritional values, and body care. This paper presents a literature review of the properties of argan oil and their application.

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“…23 Briefly, 150 L of Cur-PEA NPs or free Cur was placed in dialysis tube(molecular mass cutoff is 3.0 kDa and the dialysis area is 1 cm 2 ). The dialysis tubes were incubated in 10 mL of PBS (pH = 7 4) containing Tween 80 (0.5% wt) at 37 C with gentle shaking (100 rpm).…”

Section: In Vitro Drug Release Studymentioning

confidence: 99%

“…A more promising method therefore appears to be drug incorporation into a nanoparticle matrix. [23][24][25] Doxorubicin (DOX), an anthracycline antibiotic, is used for the treatment of a variety of malignancies including breast, ovarian, prostate, brain, lung and leukemia due to its broad spectrum of antitumor activity, 26 27 Curcumin (Cur), a yellow pigment in the spice turmeric has been reported for its potential chemopreventive and chemotherapeutic activity through various aspects, including cell cycle arrest, differentiation, and apoptosis. [28][29][30] A few published studies have indicated that curcumin is capable of increasing DOX effectiveness in cancer cell, coadministration of DOX and Cur in PLGA NPs can promote the cytotoxicity by both the drugs in vitro in leukemic cells.…”

Section: Introductionmentioning

confidence: 99%

Enhanced 4T1 Breast Carcinoma Anticancer Activity by Co-Delivery of Doxorubicin and Curcumin with Core–Shell Drug-Carrier Based on Heparin Modified Poly(L-lactide) Grafted Polyethylenimine Cationic Nanoparticles

Guo¹,

Li²,

Yang³

et al. 2014

j biomed nanotechnol

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Use of single chemotherapy agents has shown some limitations in anti-tumor treatment, such as development of drug resistance, severe adverse reactions and limited regime for therapeutic use. Combination of two or more therapeutic drugs is a feasible strategy to overcome these limitations. This paper reports study of co-delivery by core-shell nanoparticles (NPs) with hydrophobic PLLA core loaded with curcumin (Cur) and hydrophilic heparin shell adsorbing Doxorubicin (DOX). Characterizations of Cur-PEA NPs, Cur-PEA/heparin NPs and DOX adsorbing into Cur-PEA/heparin NPs (DOX-Cur NPs) were also investigated by transmission electron microscope (TEM) and Malvern Zetasizer. Studies on cellular uptake of DOX-Cur NPs demonstrated that both drugs were effectively taken up by 4T1 tumor cells. Furthermore, DOX-Cur NPs suppressed 4T1 tumor cells growth more efficiently than either DOX or Cur alone at the same concentrations, as measured by flow cytometry (FCM). We found out that intravenous injection of DOX-Cur NPs efficiently inhibited growth of subcutaneous 4T1 breast carcinoma in vivo (p < 0.01) and prolonged survival of the treated 4T1 breast carcinoma mice. Moreover, the pathological damage to the cardiac tissue in mice treated with DOX-Cur NPs was significantly less severe than that of mice treated with free DOX. This study suggested that DOX-Cur NPs may have promising applications in breast carcinoma therapy.

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Argan Oil Nanoemulsions as New Hydrophobic Drug-Loaded Delivery System for Transdermal Application

Cited by 14 publications

References 0 publications

Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application

Elaboration of Nanoparticles Containing Indomethacin: Argan Oil for Transdermal Local and Cosmetic Application

The Properties and Application of Argan Oil in Cosmetology

Enhanced 4T1 Breast Carcinoma Anticancer Activity by Co-Delivery of Doxorubicin and Curcumin with Core–Shell Drug-Carrier Based on Heparin Modified Poly(L-lactide) Grafted Polyethylenimine Cationic Nanoparticles

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