ARFI-based tissue elasticity quantification and kidney graft dysfunction: First clinical experiences

Stock, Konrad; Klein, Burkhard; Cong, M T Vo; Regenbogen, Christina; Kemmner, Stephan; Büttner, Maike; Wagenpfeil, Stefan; Matevossian, Edouard; Renders, Lutz; Heemann, Uwe; Küchle, Claudius

doi:10.3233/ch-2011-1503

Cited by 63 publications

(36 citation statements)

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“…Most published studies were performed on transplanted kidneys. [7][8][9][10] In nontransplanted kidneys, we have shown that the method has strong interobserver agreement. 11 To proceed with the extensive use of this method in patients with CKD, it is important to prove whether there is any kind of relationship between renal function and the kidney shear wave speed assessed by ARFI elastography.…”

Section: Discussionmentioning

confidence: 80%

“…Acoustic radiation force impulse elastography has already been used for assessment of the kidney shear wave speed in renal transplant recipients. [7][8][9][10] The reproducibility of the method in nontransplanted kidneys has been shown in a previous study. 11 It is known from the study of liver fibrosis that liver stiffness increases with the progression of liver disease.…”

mentioning

confidence: 61%

“…17 When comparing kidney shear wave speed values and the degree of interstitial fibrosis in human renal transplant recipients, there was either no correlation at all 10,18 or a moderate positive correlation. 8 In a study performed on children with vesicoureteral reflux, the authors revealed that the kidney shear wave speed was increased in affected kidneys compared to unaffected kidneys. 19 As already mentioned in "Materials and Methods," in our study, patients with hydronephrosis were excluded.…”

Section: Discussionmentioning

confidence: 99%

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Relationship Between the Estimated Glomerular Filtration Rate and Kidney Shear Wave Speed Values Assessed by Acoustic Radiation Force Impulse Elastography

Bob

Bota

Sporea

et al. 2015

J of Ultrasound Medicine

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Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

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Relationship Between the Estimated Glomerular Filtration Rate and Kidney Shear Wave Speed Values Assessed by Acoustic Radiation Force Impulse Elastography

Bob

Bota

Sporea

et al. 2015

J of Ultrasound Medicine

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“…6 Several studies were also conducted to apply SWV measurement for evaluation of chronic interstitial fibrosis in the renal allografts of transplanted kidneys. [13][14][15] Furthermore, in a feasibility study of ARFI elastometry in healthy abdominal organs, 16 SWV values and intra-and inter-individual variance were shown to be highest in the spleen and kidneys. This remarkable degree of variance has resulted in no conclusive evidence supporting the effectiveness of ARFI elastography in patients with chronic kidney disease.…”

mentioning

confidence: 94%

Acoustic Radiation Force Impulse Elastography of the Kidneys

Asano

Ogata

Tanaka

et al. 2014

J of Ultrasound Medicine

117

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Objectives The aim of this study was to identify the main influencing factor of the shear wave velocity (SWV) of the kidneys measured by acoustic radiation force impulse elastography. Methods The SWV was measured in the kidneys of 14 healthy volunteers and 319 patients with chronic kidney disease. The estimated glomerular filtration rate was calculated by the serum creatinine concentration and age. As an indicator of arteriosclerosis of large vessels, the brachial‐ankle pulse wave velocity was measured in 183 patients. Results Compared to the degree of interobserver and intraobserver deviation, a large variance of SWV values was observed in the kidneys of the patients with chronic kidney disease. Shear wave velocity values in the right and left kidneys of each patient correlated well, with high correlation coefficients (r = 0.580–0.732). The SWV decreased concurrently with a decline in the estimated glomerular filtration rate. A low SWV was obtained in patients with a high brachial‐ankle pulse wave velocity. Despite progression of renal fibrosis in the advanced stages of chronic kidney disease, these results were in contrast to findings for chronic liver disease, in which progression of hepatic fibrosis results in an increase in the SWV. Considering that a high brachial‐ankle pulse wave velocity represents the progression of arteriosclerosis in the large vessels, the reduction of elasticity succeeding diminution of blood flow was suspected to be the main influencing factor of the SWV in the kidneys. Conclusions This study indicates that diminution of blood flow may affect SWV values in the kidneys more than the progression of tissue fibrosis. Future studies for reducing data variance are needed for effective use of acoustic radiation force impulse elastography in patients with chronic kidney disease.

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“…Among recently developed quantitative ultrasound imaging techniques, shear wave elastography [8] and ultrasound strain elastography [1, 2, 9, 10] have been used to assess renal cortical hardness that was mainly correlated with the grade of allograft interstitial fibrosis. Yet, little clinical work has been done on the relationship between the cortical shear wave velocity measured with acoustic radiation force impulse (ARFI) imaging and renal transplant rejection [11]. Another imaging modality, magnetic resonance poroelastography, was reported to be able to assess the poroelastic deformation of soft fluid-saturated tissue, and subsequently, it can be used to separate the mechanical response of solid and fluid components [12,13].…”

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confidence: 99%

Ultrasound Strain Relaxation Time Ratio: A Quantitative Marker for the Assessment of Cortical Inflammation/Edema in Renal Allografts

Gao¹,

Hentel²,

Kazam³

et al. 2015

Ultraschall in Med

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To evaluate the ability of ultrasound strain relaxation time ratio to assess cortical inflammation/edema in renal allografts. We prospectively assessed renal allograft cortical inflammation/edema in 16 renal transplants using ultrasound elasticity imaging and correlated the findings with kidney biopsy. Strain relaxation times in the renal cortex and reference soft tissue were produced by free-hand compression with the ultrasound transducer and estimated with 2 D speckle tracking. Compression was performed in 3-second compression-relaxation cycles (push for 1 second, constant pressure for 1 second, and release for 1 second). We propose a strain relaxation time ratio (time of cortical strain to return to zero/time of the reference strain return to zero) to assess the relationship of compression-induced time-dependent strain relaxation in the cortex and reference tissue. 16 patients were divided into a group with ≤ 25 % (n = 8) and a group with> 26 % (n = 8) cortical inflammation/edema based on the Banff score. A t-test was used to examine the difference in the strain relaxation time ratio between the two groups. The diagnostic accuracy, inter-rater reliability, and reproducibility of this technique in discriminating between the groups were tested. The strain relaxation time ratio of cortex/reference tissue was significantly higher in patients with> 26 % than in patients with ≤ 25 % cortical inflammation/edema (1.15 ± 0.10 vs. 0.91 ± 0.08, P = 0.0002). The strain relaxation time ratio has high reliability (Pearson correlation coefficient, R² = 0.93), reproducibility (intraclass correlation coefficient = 0.98, P = 0.000), and accuracy (area under curve = 1) in determining > 26 % renal cortical inflammation/edema. The strain relaxation time ratio of cortex/reference tissue can be used as a quantitative marker for the assessment of cortical inflammation/edema in renal allografts.

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ARFI-based tissue elasticity quantification and kidney graft dysfunction: First clinical experiences

Cited by 63 publications

References 0 publications

Relationship Between the Estimated Glomerular Filtration Rate and Kidney Shear Wave Speed Values Assessed by Acoustic Radiation Force Impulse Elastography

Relationship Between the Estimated Glomerular Filtration Rate and Kidney Shear Wave Speed Values Assessed by Acoustic Radiation Force Impulse Elastography

Acoustic Radiation Force Impulse Elastography of the Kidneys

Ultrasound Strain Relaxation Time Ratio: A Quantitative Marker for the Assessment of Cortical Inflammation/Edema in Renal Allografts

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