Arenavirus genetic diversity and its biological implications

Emonet, Sébastien; Torre, Juan Carlos de la; Domingo, Esteban; Sevilla, Noemı́

doi:10.1016/j.meegid.2009.03.005

Cited by 58 publications

(51 citation statements)

References 158 publications

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“…However, an alternative explanation based on the peculiarity of the GP1 region within the GPC gene has been proposed [37]. GP1 is highly variable in clades B and the A/Rec lineage and the problematic alignment of the GP1 regions represents a potentially confounding factor for these phylogenetic analyses [37].…”

Section: Recombination Events In Negative Sense Rna Virusesmentioning

confidence: 99%

Homologous Recombination in Negative Sense RNA Viruses

Han

Worobey

2011

Viruses

104

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Recombination is an important process that influences biological evolution at many different levels. More and more homologous recombination events have been reported among negative sense RNA viruses recently. While sporadic authentic examples indicate that homologous recombination does occur, recombination seems to be generally rare or even absent in most negative sense RNA viruses, and most of the homologous recombination events reported in the literature were likely generated artificially due to lab contamination or inappropriate bioinformatics methods. Homologous recombination in negative sense RNA viruses should be reported with caution in the future, and only after stringent quality control efforts. Moreover, co-infection experiments should be performed to confirm whether recombination can occur.

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Section: Recombination Events In Negative Sense Rna Virusesmentioning

confidence: 99%

Homologous Recombination in Negative Sense RNA Viruses

Han

Worobey

2011

Viruses

104

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“…LCMV exhibits the high mutation rates and quasispecies dynamics typical of RNA viruses, and this confers this pathogen great adaptability to different environments (26,28,85). Because of the need to explore new strategies for the control of arenavirus-associated disease, we took LCMV as a model system to investigate lethal mutagenesis or virus extinction through an increase in the mutation rate (for reviews, see references 6, 24, 32, and 38).…”

mentioning

confidence: 99%

Ribavirin Can Be Mutagenic for Arenaviruses

Moreno

Gallego

Sevilla

et al. 2011

J Virol

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Arenaviruses include several important human pathogens, and there are very limited options of preventive or therapeutic interventions to combat these viruses. An off-label use of the purine nucleoside analogue ribavirin (1-␤-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide) is the only antiviral treatment currently available for arenavirus infections. However, the ribavirin antiviral mechanism action against arenaviruses remains unknown. Here we document that ribavirin is mutagenic for the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) in cell culture. The mutagenic activity of ribavirin on LCMV was observed under single-and multiple-passage regimes and could not be accounted for by a decrease of the intracellular GTP pool promoted by ribavirin-mediated inhibition of inosine monophosphate dehydrogenase (IMPDH). Our findings suggest that the antiviral activity of ribavirin on arenaviruses might be exerted, at least partially, by lethal mutagenesis. Implications for antiarenavirus therapy are discussed.

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“…[93,94] and Chapare [95]) or from rodents [96][97][98][99][100][101]. There is a continuing need to maintain a surveillance of these and related viruses because with the great large number of different Arenavirus host reservoirs, the great genetic diversity among virus species, and the ability of the viruses to adapt to rapidly changing environments, there is concern that a new virus potentially pathogenic for humans could arise [102]. Indeed this happened recently with Lujo virus, which led to several subsequent nosocomial infections [93,94].…”

Section: Bats As Reservoirs Of Other Virus Families -Some Additional mentioning

confidence: 99%