Area program in population genetics

Neel, James V.; Gershowitz, H.; Bloom, Amy; Sing, Charles F.

doi:10.2172/4473873

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…Mutant phenotypes in double mutant combination (1:1 ratio) can be explained in several ways, as additive or synergistic gene insufficiency. Several loci are known and others have been reported here, that in heterozygous condition affect the expression of bithorax heterozygotes Garcia-Bellido, 1978, 1981;Mortin and Lefevre, 1981;Ingham and Whittle, 1980;Gans et al, 1980), or achaete-scute mutants (Neel, 1941;Sturtevant, 1970). Other genetic tests are 309 necessary to classify their wild-type products as related to the activation of the structural gene, to its transcription, or to its expression in developmental terms (see Garcia-Bellido and Capdevila, 1981;Garcia-Bellido, 1981a, 1981b, for discussion).…”

Section: Gene-dose Titration Analysismentioning

confidence: 64%

Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila.

Botas¹,

Prado²,

Garcı́a-Bellido³

1982

The EMBO Journal

122

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We have searched for trans‐regulatory genes in two genetic systems in Drosophila, the bithorax complex (BX‐C) and the achaete‐scute complex (AS‐C). Previous genetic evidence suggests that the activation of both BX‐C and AS‐C, depends on trans‐regulatory genes (Polycomb, Pc, in the former and hairy, h, in the latter) acting in a negative type of control. Mutants of these regulatory genes in heterozygous condition have dominant derepression phenotypes in flies with extra doses of the corresponding gene complexes. We have searched for new loci, with similar gene‐dose relationships. We have isolated only new alleles (six) of Pc in the BX‐C experiment. In the AS‐C experiment four h alleles, and 13 alleles of a new locus (extramacrochaetae, emc) have been discovered. Whereas the h locus shows specific interactions upon achaete, the new locus, emc, is specific for the scute part of the AS‐C. Statistical analysis suggests that these are the only loci in the genome with those dose‐dependent properties in the two systems.

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Section: Gene-dose Titration Analysismentioning

confidence: 64%