Are we missing respiratory viral infections in infants and children? Comparison of a hospital-based quality management system with standard of care

Alchikh, Maren; Conrad, Tim; Hoppe, Ch.; Ma, Xiaolin; Broberg, Eeva; Penttinen, Pasi; Reiche, Janine; Biere, Barbara; Schweiger, Brunhilde; Rath, Barbara

doi:10.1016/j.cmi.2018.05.023

Cited by 16 publications

(35 citation statements)

References 26 publications

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“…Epidemiological understanding of seasonal coronaviruses (sCoVs) is currently incomplete in many settings around the world, primarily due to the fact that these viruses are not a part of standard diagnostic armamentarium, or testing is guided by specific clinical case definitions (6). It is well-established that sCoVs are endemically found in co-circulation with other prevalent respiratory viruses, which is a principal reason why co-infections are commonly observed (7)(8)(9).…”

Section: Seasonal Coronavirusesmentioning

confidence: 99%

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

Ljubin‐Sternak

Meštrović

Lukšić

et al. 2021

Front. Public Health

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Respiratory viral infections are the leading cause of morbidity and mortality in the world; however, there are several groups of viruses that are insufficiently routinely sought for, and can thus be considered neglected from a diagnostic and clinical standpoint. Timely detection of seasonality of certain respiratory viruses (e.g., enveloped viruses such as seasonal coronaviruses) in the local context can aid substantially in targeted and cost-effective utilization of viral diagnostic approaches. For the other, non-enveloped and year-round viruses (i.e., rhinovirus, adenovirus, and bocavirus), a continuous virological diagnosis needs to be implemented in clinical laboratories to more effectively address the aetiology of respiratory infections, and assess the overall impact of these viruses on disease burden. While the coronavirus disease 2019 (COVID-19) pandemic is still actively unfolding, we aimed to emphasize the persistent role of seasonal coronaviruses, rhinoviruses, adenoviruses and bocaviruses in the aetiology of respiratory infections. Consequently, this paper concentrates on the burden and epidemiological trends of aforementioned viral groups on a global level, but also provides a snapshot of their prevalence patterns in Croatia in order to underscore the potential implications of viral seasonality. An overall global prevalence in respiratory tract infections was found to be between 0.5 and 18.4% for seasonal coronaviruses, between 13 and 59% for rhinoviruses, between 1 and 36% for human adenoviruses, and between 1 and 56.8% for human bocaviruses. A Croatian dataset on patients with respiratory tract infection and younger than 18 years of age has revealed a fairly high prevalence of rhinoviruses (33.4%), with much lower prevalence of adenoviruses (15.6%), seasonal coronaviruses (7.1%), and bocaviruses (5.3%). These insights represent a relevant discussion point in the context of the COVID-19 pandemic where the testing of non-SARS-CoV-2 viruses has been limited in many settings, making the monitoring of disease burden associated with other respiratory viruses rather difficult.

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Section: Seasonal Coronavirusesmentioning

confidence: 99%

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

Ljubin‐Sternak

Meštrović

Lukšić

et al. 2021

Front. Public Health

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“…The concept of measuring individual-level differences in disease severity has drawn the attention of both public health stakeholders and regulatory agencies in recent years (18)(19)(20). The impact of RSV infections of course should be differentiated from the disease caused by influenza and other viral respiratory infections (21,22). However, a recent extensive literature review and prospective cohort have shown that in infants and children this cannot be done based on clinical symptoms alone; distinguishing RSV from other viral respiratory infections requires laboratory confirmation (23,24).…”

Section: Epidemiology Of Rsv Infectionmentioning

confidence: 99%

“…RSV is a single-stranded RNA virus (Figs. 1 and 2), which represents the most frequent viral cause of acute lower respiratory tract infection (ALRTI) in infants, with a worldwide distribution and seasonal occurrence (2)(3)(4)(5). It was first isolated in 1956 from nasal secretions of chimpanzees with rhinorrhea and coryza; the novel virus was…”

Section: Introductionmentioning

confidence: 99%

Update on current views and advances on RSV infection (Review)

et al. 2020

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Respiratory syncytial virus (RSV) infection represents an excellent paradigm of precision medicine in modern paediatrics and several clinical trials are currently performed in the prevention and management of RSV infection. A new taxonomic terminology for RSV was recently adopted, while the diagnostic and omics techniques have revealed new modalities in the early identification of RSV infections and for better understanding of the disease pathogenesis. coordinated clinical and research efforts constitute an important step in limiting RSV global predominance, improving epidemiological surveillance, and advancing neonatal and paediatric care. This review article presents the key messages of the plenary lectures, oral presentations and posters of the '5th workshop on paediatric virology' (Sparta, Greece, 12th October 2019) organized by the Paediatric Virology Study Group, focusing on recent advances in the epidemiology, pathogenesis, diagnosis, prognosis, clinical management and prevention of RSV infection in childhood.

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“…In a quality improvement (QI) programme in Berlin in collaboration with the National Reference Centre for Influenza at the Robert Koch institute, we established a QI team (independent from routine care) that would assess all influenza-like illness (ILI) patients taking samples to be tested for respiratory viruses. We learned that without the QI system in place, we would have missed the majority of specific respiratory viral diagnoses (5). Among 6,073 individuals with ILI qualifying for the QI programme, only 8.7% (528/6,073) would have undergone virus diagnostics during routine care.…”

Section: Questions and Answersmentioning

confidence: 99%

“…Emergency room surveillance based on ICD codes would have missed 61% (359/587) of influenza diagnoses. Less than half (49.6%, 398/802) of all RSV cases received RSV-specific ICD codes (such as J20.5: ‘acute bronchitis due to RSV’) (5). Considering these challenges, we were interested in the question whether point of care testing could help us make accurate diagnoses more quickly and also to make the test results known to the patients and their caretakers while they were still with us in the Emergency Department (ED) (6).…”

Section: Questions and Answersmentioning

confidence: 99%

Advancing challenges in Paediatric Virology: An interview with Professor Barbara A. Rath, Co‑founder and Chair of the Vienna Vaccine Safety Initiative

Mammas

Spandidos

2019

Exp Ther Med

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The Vienna Vaccine Safety Initiative (ViVI) is an international, scientific, non-profit, research organization, which aims to promote research, clinical practice and communication on Paediatric Infectious Diseases (PID) in a globalized healthcare setting, to facilitate the implementation of high standards in vaccine safety and efficacy and to support international and interdisciplinary scientific collaboration. Professor Barbara A. Rath, Chair and Co-founder of the Vienna Vaccine Safety Initiative, advocates for the establishment of global research networks in the field of neonatal and paediatric viral infections. Viruses do not respect borders, and large datasets are required and joint action is necessary to further strengthen efforts towards viral diseases eradication and prevention. She encourages the paediatric community to embrace the new opportunities technology offers for healthcare and medical education. To date, the Vienna Vaccine Safety Initiative has developed a number of innovative mobile applications and diagnostic tools, such as the 'VAccApp', which helps parents understand which vaccines were administered to their children, the 'ViVI Disease Severity Score', which measures clinical severity in patients with acute respiratory infections and flu-like illnesses, the 'VACC Tool', which assesses patient's clinical presentation to a set of diagnostic algorithms for adverse events following immunization and the 'ViVI Health Survey', which enables children and young adults on the move to report health needs securely and confidentially. Professor Rath agrees that during this decade there is momentum in the field of Paediatric Virology, as new antivirals and vaccines emerge and are finally becoming available to children. In the future, 'in-house' specialists for Paediatric Virology could be helpful to provide quality of care and reduce antimicrobial resistance by providing individual as well as hospital-wide consultations and advice. She estimates that Paediatric Virology will eventually find its place in the context of PID and Vaccinology. Contents 1. Introduction 2. Questions and Answers

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Are we missing respiratory viral infections in infants and children? Comparison of a hospital-based quality management system with standard of care

Cited by 16 publications

References 26 publications

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

Update on current views and advances on RSV infection (Review)

Advancing challenges in Paediatric Virology: An interview with Professor Barbara A. Rath, Co‑founder and Chair of the Vienna Vaccine Safety Initiative

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