Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms

Troyer, Emily A.; Kohn, Jaden R.; Hong, Suzi

doi:10.1016/j.bbi.2020.04.027

Cited by 853 publications

(885 citation statements)

References 63 publications

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“…The fear of being infected by SARS-CoV-2 has become a burden in the everyday lives of people around the world. As a result, efforts have been made by experts worldwide to evaluate the effect of the stress, anxiety, depression, and fear towards this pandemic (Dyer and Harris 2020;Rajkumar 2020;Troyer et al 2020) .…”

Section: Discussionmentioning

confidence: 99%

Comparison of Fear of COVID-19 in Medical and Nonmedical Personnel in a Public Hospital in Mexico

Barbosa-Camacho¹,

García-Reyna²,

Cervantes-Cardona³

et al. 2020

Preprint

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The world is social distancing and compulsory confinement has caused stress, psychological instability, stigmatization, fear, and discrimination in the general population. In this cross-sectional survey study, we administered the Fear of COVID-19 Scale (FCV-19S) to hospital medical and nonmedical personnel. A total of 1,216 participants were included in the study. We found that the global FCV-19S mean score was 16.4 ± 6.1, with a significant difference between women and men’s scores. Medical students presented higher scores than experienced medical personnel. As the medical and nursing personnel scored higher on the FCV-19S than the nonmedical hospital staff, our findings suggest that greater knowledge of medicine or infectious diseases could decrease the overall psychological impact of the pandemic disease.

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Section: Discussionmentioning

confidence: 99%

Comparison of Fear of COVID-19 in Medical and Nonmedical Personnel in a Public Hospital in Mexico

Barbosa-Camacho¹,

García-Reyna²,

Cervantes-Cardona³

et al. 2020

Preprint

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“…poorly understood. In addition to the fear of transmitting the infection to colleagues and family members coupled with the dilemma of applying for sick leave in an already strained healthcare sector, many healthcare workers develop burnout and may experience a sense of intense fear, stigmatization and ostracism when displaying physical symptoms suggestive of the virus infection, which often leads to negative psychological pain (Nezlek et al, 2012;Troyer et al, 2020). This phenomenon has already been described in the studies during the current COVID-19 outbreak (Wang et al, 2020a) as well as previous Ebola crisis (Matua and Van Der, 2015).…”

Section: Tablementioning

confidence: 99%

A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak

Chew

Lee

Tan

et al. 2020

Brain, Behavior, and Immunity

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1,360

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Objective: Since the declaration of the coronavirus 2019 (COVID-19) outbreak as pandemic, there are reports on the increased prevalence of physical symptoms observed in the general population. We investigated the association between psychological outcomes and physical symptoms among healthcare workers. Methods: Healthcare workers from 5 major hospitals, involved in the care for COVID-19 patients, in Singapore and India were invited to participate in a study by performing a self-administered questionnaire within the period of February 19 to April 17, 2020. Healthcare workers included doctors, nurses, allied healthcare workers, administrators, clerical staff and maintenance workers. This questionnaire collected information on demographics, medical history, symptom prevalence in the past month, Depression Anxiety Stress Scales (DASS-21) and the Impact of Events Scale-Revised (IES-R) instrument. The prevalence of physical symptoms displayed by healthcare workers and the associations between physical symptoms and psychological outcomes of depression, anxiety, stress, and post-traumatic stress disorder (PTSD) were evaluated. Results: Out of the 906 healthcare workers who participated in the survey, 48 (5.3%) screened positive for moderate to very-severe depression, 79 (8.7%) for moderate to extremely-severe anxiety, 20 (2.2%) for moderate to extremely-severe stress, and 34 (3.8%) for moderate to severe levels of psychological distress. The commonest reported symptom was headache (32.3%), with a large number of participants (33.4%) reporting more than four symptoms. Participants who had experienced symptoms in the preceding month were more likely to be older, have pre-existing comorbidities and a positive screen for depression, anxiety, stress, and PTSD. After adjusting for age, gender and comorbidities, it was found that depression (OR 2.79, 95% CI 1.54-5.07, p = 0.001), anxiety (OR 2.18, 95% CI 1.36-3.48, p = 0.001), stress (OR 3.06, 95% CI 1.27-7.41, p = 0.13), and PTSD (OR 2.20, 95% CI 1.12-4.35, p = 0.023) remained significantly associated with the presence of physical

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“…These circumstances have already been described in countries where the situation has overwhelmed the health system (Kang et al, 2020; Mantica et al, 2020; Mowbray, 2020; Sindhu & Gupta, 2020), as well as in those areas where disease outbreaks were contained (Ho et al, 2020). The related increase of psychopathological disorders Troyer et al, 2020) also added to the pressure on health systems in terms of resources and rapid strategies to be adopted for coping the outbreak of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Psychometric properties of the Spanish version of the Fear of COVID-19 Scale (FCV-19S)

Barrios

Ríos-González

O’Higgins

et al. 2020

Preprint

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Globally, mental health impairments have been described based on the fear of the infection generated by the COVID-19 pandemic. The aim of this study is to test the psychometric properties of the Spanish validation the Fear of COVID-19 Scale (FCV-19S), which has been recently developed to measure fear quantitatively. Participants were recruited through an Internet-based survey. 1077 subjects were included. To establish construct validity, an exploratory factor analysis was performed using the KMO test, which was adequate, and the Bartlett sphericity test, which was significant (p <.0001). The CFI, NFI, GFI, TLI and RMSEA indices were used to evaluate the model and showed good adjustment. Cronbach’s alpha showed valid internal consistency (α=0.86). This validation is supported by significant correlation (p <.001) with the HADS scale for anxiety and depression and with the Fear Questionnaire scale for specific phobia. In conclusion, the Spanish version of the FCV-19S is a 7-item scale with two dimensions, psychological symptoms (items 1, 2, 4, and 5) and physiological symptoms (items 3, 6, and 7) with robust psychometric properties.

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Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms

Cited by 853 publications

References 63 publications

Comparison of Fear of COVID-19 in Medical and Nonmedical Personnel in a Public Hospital in Mexico

Comparison of Fear of COVID-19 in Medical and Nonmedical Personnel in a Public Hospital in Mexico

A multinational, multicentre study on the psychological outcomes and associated physical symptoms amongst healthcare workers during COVID-19 outbreak

Psychometric properties of the Spanish version of the Fear of COVID-19 Scale (FCV-19S)

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