Are Throat Pain and Otalgia Predictive of Perineural Invasion in Squamous Cell Carcinoma of the Oropharynx?

Fahmy, Mina D.; Clegg, Devin J; Belcastro, Alexandra; Smith, Blaine D.; Heidel, R. Eric; Carlson, Eric R.; Hechler, Benjamin

doi:10.1016/j.joms.2021.08.265

Cited by 6 publications

(2 citation statements)

References 42 publications

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“… 159 Patients may feel ear pain, throat pain, and pain in other areas involved in PNI. 160 Although its mechanisms are not yet understood, PNI has been shown to be linked to an elevated risk of recurrence, regional transfer, distant metastasis, and overall worse prognosis (Fig. 3b ).…”

Section: Non-developmental Diseases Caused By Reciprocal Regulation B...mentioning

confidence: 99%

The interaction between the nervous system and the stomatognathic system: from development to diseases

et al. 2023

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The crosstalk between the nerve and stomatognathic systems plays a more important role in organismal health than previously appreciated with the presence of emerging concept of the “brain-oral axis”. A deeper understanding of the intricate interaction between the nervous system and the stomatognathic system is warranted, considering their significant developmental homology and anatomical proximity, and the more complex innervation of the jawbone compared to other skeletons. In this review, we provide an in-depth look at studies concerning neurodevelopment, craniofacial development, and congenital anomalies that occur when the two systems develop abnormally. It summarizes the cross-regulation between nerves and jawbones and the effects of various states of the jawbone on intrabony nerve distribution. Diseases closely related to both the nervous system and the stomatognathic system are divided into craniofacial diseases caused by neurological illnesses, and neurological diseases caused by an aberrant stomatognathic system. The two-way relationships between common diseases, such as periodontitis and neurodegenerative disorders, and depression and oral diseases were also discussed. This review provides valuable insights into novel strategies for neuro-skeletal tissue engineering and early prevention and treatment of orofacial and neurological diseases.

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Section: Non-developmental Diseases Caused By Reciprocal Regulation B...mentioning

confidence: 99%

The interaction between the nervous system and the stomatognathic system: from development to diseases

et al. 2023

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“…Pain stemming from cancer is a prevalent affliction among patients with malignancies, with a majority reporting intense pain at some juncture of their condition. PNI not only exacerbates this cancer-related pain but also emerges as a predictive pathological indicator of early metastatic activity, providing vital insights into the prognosis of the disease [12,14,43,44]. Notably, researchers have pinpointed pain as a key variable intricately tied to PNI across various tumor localizations in patients with head and neck cancer (HNC), regardless of whether the tumors originate from the oropharynx or other non-oropharyngeal regions [45].…”

Section: The Methods To Detect Pni In Cancermentioning

confidence: 99%

Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

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CAO,

XIAO

et al. 2024

BIOCELL

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Perineural invasion (PNI), a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread, has the capacity to extend well beyond the primary tumor site, infiltrating distant regions devoid of lymphatic or vascular structures. PNI often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of cancers. Despite its clinical significance, the underlying molecular mechanisms of PNI remain elusive, complicating the development of specific and efficacious diagnostic and therapeutic strategies. In the realm of cancer research, non-coding RNAs (ncRNAs) have attracted considerable attention due to their multifaceted roles and cancer-specific expression profiles, positioning them as promising candidates for applications in cancer diagnostics, prognostics, and treatment. Among the various types of ncRNAs, microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have emerged as influential players in PNI. Their involvement is increasingly recognized as a contributing factor to tumor progression and therapeutic resistance. Our study synthesizes and explores the diverse functions and mechanisms of ncRNAs in relation to PNI in cancer. This comprehensive review aims to shed light on cutting-edge perspectives that could pave the way for innovative diagnostic and therapeutic approaches to address the challenges posed by PNI in oncology.

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Pretreatment pain predicts perineural invasion in patients with head and neck squamous cell carcinoma

Scheff

Harris

et al. 2023

Support Care Cancer

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Are Throat Pain and Otalgia Predictive of Perineural Invasion in Squamous Cell Carcinoma of the Oropharynx?

Cited by 6 publications

References 42 publications

The interaction between the nervous system and the stomatognathic system: from development to diseases

The interaction between the nervous system and the stomatognathic system: from development to diseases

Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

Pretreatment pain predicts perineural invasion in patients with head and neck squamous cell carcinoma

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