Pretreatment pain predicts perineural invasion in patients with head and neck squamous cell carcinoma

Scheff, Nicole N.; Harris, Alexandria; Li, Jinhong; Horan, Nicole L.; Kubik, Mark; Kim, Seungwon; Nilsen, Marci Lee

doi:10.1007/s00520-023-07872-7

Cited by 3 publications

(2 citation statements)

References 51 publications

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“…PNI not only exacerbates this cancer-related pain but also emerges as a predictive pathological indicator of early metastatic activity, providing vital insights into the prognosis of the disease [12,14,43,44]. Notably, researchers have pinpointed pain as a key variable intricately tied to PNI across various tumor localizations in patients with head and neck cancer (HNC), regardless of whether the tumors originate from the oropharynx or other non-oropharyngeal regions [45].…”

Section: The Methods To Detect Pni In Cancermentioning

confidence: 99%

Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

LI,

CAO,

XIAO

et al. 2024

BIOCELL

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Perineural invasion (PNI), a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread, has the capacity to extend well beyond the primary tumor site, infiltrating distant regions devoid of lymphatic or vascular structures. PNI often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of cancers. Despite its clinical significance, the underlying molecular mechanisms of PNI remain elusive, complicating the development of specific and efficacious diagnostic and therapeutic strategies. In the realm of cancer research, non-coding RNAs (ncRNAs) have attracted considerable attention due to their multifaceted roles and cancer-specific expression profiles, positioning them as promising candidates for applications in cancer diagnostics, prognostics, and treatment. Among the various types of ncRNAs, microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have emerged as influential players in PNI. Their involvement is increasingly recognized as a contributing factor to tumor progression and therapeutic resistance. Our study synthesizes and explores the diverse functions and mechanisms of ncRNAs in relation to PNI in cancer. This comprehensive review aims to shed light on cutting-edge perspectives that could pave the way for innovative diagnostic and therapeutic approaches to address the challenges posed by PNI in oncology.

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Section: The Methods To Detect Pni In Cancermentioning

confidence: 99%

Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

LI,

CAO,

XIAO

et al. 2024

BIOCELL

View full text Add to dashboard Cite

show abstract

“…The presence of PNI is often a harbinger of tumor-associated pain and has been correlated with a poor prognosis in several cancers, such as colorectal cancer, prostate cancer, and pancreatic adenocarcinoma [45][46][47]. In HNSCC, particularly OSCC, pretreatment pain is also an important variable that is uniquely associated with PNI [48,49]. In HNSCC, the incidence of PNI varies from 25% to 80% [50][51][52], and several studies have positively related PNI to aggressiveness and decreased survival [23,27,53].…”

Section: Definition Diagnostics and Clinical Relevancementioning

confidence: 99%

Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer

Liang,

Hess

2024

Cells

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The neurobiology of tumors has attracted considerable interest from clinicians and scientists and has become a multidisciplinary area of research. Neural components not only interact with tumor cells but also influence other elements within the TME, such as immune cells and vascular components, forming a polygonal relationship to synergistically facilitate tumor growth and progression. This review comprehensively summarizes the current state of the knowledge on nerve–tumor crosstalk in head and neck cancer and discusses the potential underlying mechanisms. Several mechanisms facilitating nerve–tumor crosstalk are covered, such as perineural invasion, axonogenesis, neurogenesis, neural reprogramming, and transdifferentiation, and the reciprocal interactions between the nervous and immune systems in the TME are also discussed in this review. Further understanding of the nerve–tumor crosstalk in the TME of head and neck cancer may provide new nerve-targeted treatment options and help improve clinical outcomes for patients.

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Perineural Invasion Is Associated With Function-evoked Pain and Altered Extracellular Matrix in Patients With Head and Neck Squamous Cell Carcinoma

Santi,

Zhang,

Asam

et al. 2024

The Journal of Pain

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Pretreatment pain predicts perineural invasion in patients with head and neck squamous cell carcinoma

Cited by 3 publications

References 51 publications

Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer

Perineural Invasion Is Associated With Function-evoked Pain and Altered Extracellular Matrix in Patients With Head and Neck Squamous Cell Carcinoma

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