Are there depression and anxiety genetic markers and mutations? A systematic review

Lacerda-Pinheiro, Sally França; Pinheiro, Roberto Flávio Fontenelle; Lima, Marcos Antônio Pereira de; Silva, Cláudio Gleidiston Lima da; Santos, Maria do Socorro Vieira dos; Júnior, Antônio Gilvan Teixeira; Oliveira, Pedro Neto Lima de; Ribeiro, Karla Denise Barros; Neto, Modesto Leite Rolim; Bianco, Bianca

doi:10.1016/j.jad.2014.07.016

Cited by 59 publications

(37 citation statements)

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“…Especially, I h controls rhythmic activity of cardiac pacemaker cells and spontaneously firing neurons. Dysfunctions of HCN channels are related to the pathogenesis of several diseases [1,[5][6][7][8][9][10][11] . Many ion channels, including HCN, appear to be evolutionarily conserved; orthologs with identical domains and transmembrane topology are found in organisms from worms to man [12] .…”

Section: Introductionmentioning

confidence: 99%

Evolutionary acquisition and divergence of vertebrate HCN2 palmitoylation

2017

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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control rhythmic activity in mammalian nervous system and heart. Among four HCN family isoforms (HCN1-4), mouse HCN2 is specifically palmitoylated at five cysteine residues in its N-terminus. Here, we further focused on conservation of these palmitoylation sites found in vertebrate HCN2 orthologs. Analysis of sequence databases provided an insight into stepwise acquisition of HCN2 palmitoylation motifs in vertebrate lineages. The mechanism of HCN2 palmitoylation itself has been broadly conserved throughout vertebrate species in spite of the divergence of HCN2 full-length amino acid sequences during molecular evolution. Furthermore, there exist vertebrate class-specific variation of palmitoylation motifs. Our findings mean that dynamic regulation of HCN2 made possible by reversible post-translational protein palmitoylation may be critical for refined functions of the vertebrate nervous system and heart.

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Section: Introductionmentioning

confidence: 99%

Evolutionary acquisition and divergence of vertebrate HCN2 palmitoylation

2017

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“…It is important to highlight that this combination of genetic predisposition and global psychosocial stressing factors is fundamental to deflagrate the occurrence of complete episodes of mood disorders, but do not have significant influence for provoking the subsequent manifestations (Kessler, 1997;Lacerda-Pinheiro et al, 2014). Patients with bipolar disorder with or without positive dysregulation profile significantly differed from patterns regarding to of psychiatric comorbidity, psychosocial and psychoeducational dysfunction, and cognitive deficits, as well as in their risk for bipolar disorder in first degree relatives (Biederman et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Bipolar disorder incidence between children and adolescents: A brief communication

Neto

Silva

Júnior

et al. 2015

Journal of Affective Disorders

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“…Interestingly, women are more susceptible to depression. The complexity of depression is demonstrated by the existence of a variety of factors involved in this disorder, such as biological (e.g., genetic) [3,4] differences and brain chemistry (i.e., neurotransmitters, hormones, decreased serotonin levels in the blood, and last, but not least, a person’s genes) [2,5]. There are many factors that seem to increase the risk of triggering depression as well, including low self-esteem, traumatic/stressful events, drugs, alcohol, and other mental health disorders [2].…”

Section: Introductionmentioning

confidence: 99%

“…Finally, genetic factors play a major role in depression, with 30–40% of these patients exhibiting genetic symptoms [3,4]. The studies revealed a 40–50% prevalence of depression in monozygotic twins and 25% in dizygotic twins.…”

Section: Introductionmentioning

confidence: 99%

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Depression: Evolutionary New Neural Circuitries Are Still Adjusting for Cognition

Graczynska¹,

Stefano²

2015

Med Sci Monit Basic Res

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Depression can be both normal and abnormal, and the balance of its expression determines the behavioral outcome/diagnosis. It is a complex pathophysiology based on a heterogeneous syndrome whose etiology is diverse as well. Within the context of a central nervous system, the nervous system blueprint can be found in single cells (sensory, motor, and integrative processes). These consolidated functions provide for novel coping strategies for survival. The maintenance and evolvement of this system into a central nervous system is based on conserving these functions, including chemical messengers and functionality in having specific cells mediate these primordial functions. Additionally, this neural coping strategy provides advantages for DNA. Thus, with different neural cells at work, pathways/networks would evolve, producing more complex behaviors and become a very critical phenomenon for future advances. This evolvement has taken over 1 billion years to develop. In so doing, as with any new programming (e.g., cognition), errors will occur. Given the widespread qualities of depression, it is surmised that this abnormality, and other psychiatric disorders, may emerge due to inherent neural weaknesses related to cognition being a recent evolutionary development.

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Are there depression and anxiety genetic markers and mutations? A systematic review

Cited by 59 publications

References 50 publications

Evolutionary acquisition and divergence of vertebrate HCN2 palmitoylation

Evolutionary acquisition and divergence of vertebrate HCN2 palmitoylation

Bipolar disorder incidence between children and adolescents: A brief communication

Depression: Evolutionary New Neural Circuitries Are Still Adjusting for Cognition

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