Are there any seasonal variations in 25-hydroxyvitamin D and parathyroid hormone serum levels in children and adolescents with severe obesity?

Durá-Travé, Teodoro; Gallinas-Victoriano, Fidel; Malumbres-Chacón, María; Ahmed-Mohamed, Lotfi; Chueca-Guindulain, María Jesús; Berrade-Zubiri, Sara

doi:10.1007/s00431-020-03857-4

Cited by 5 publications

(10 citation statements)

References 31 publications

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“…While serum PTH1-84 levels tended to be higher in both severe and moderate vitamin D-deficient groups compared to the vitamin D-sufficient group, with a P- value of borderline statistical significance ( P = 0.053), they were negatively correlated with serum 25(OH)D levels among the study sample ( P = 0.010). Our results are aligned with previous studies that demonstrated increases in serum PTH1-84 levels in overweight and obese subjects (Snijder et al, 2005; Kamycheva et al, 2004; Durá-Travé et al, 2021), and with those that reported an inverse relationship between PTH1-84 and 25(OH)D levels in adult men and women (Martins et al, 2017; Al-Daghri et al, 2017; Olmos et al, 2016; Saadi et al, 2006). Nevertheless, when the association between PTH1-84 and 25(OH)D levels was assessed separately in vitamin D-deficient and –sufficient groups, it was not statistically significant.…”

Section: Discussionsupporting

confidence: 92%

“…While there was no significant difference in serum 25(OH)D levels between weight status groups (Table 1), BMI was inversely correlated with serum 25(OH)D concentration in vitamin D-deficient women. Despite the weakness of this correlation, our results corroborate and contribute to the existing literature regarding the positive relationship between overweight/obesity and hypovitaminosis D (Lapik et al, 2020; Pereira-santos et al, 2015, Migliaccio et al, 2019; Vanlint, 2013; Durá-Travé et al, 2021; Vimaleswaran et al, 2013). This association may be attributed to several contributing factors, such as altered vitamin D metabolism, behaviours leading to reduced sunlight exposure, or decreased intake of vitamin D-enriched foods among overweight/obese individuals.…”

Section: Discussionsupporting

confidence: 87%

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Vitamin D status and its relationship with obesity indicators in Moroccan adult women

et al. 2022

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Background: Although vitamin D deficiency has been studied in various populations, there are few data on its prevalence and associated factors among Moroccan women. Aim: To determine the prevalence of vitamin D deficiency and investigate its association with body mass index (BMI), waist circumference, and serum concentrations of parathyroid hormone, calcium, and phosphorus in a sample of Moroccan adult women. Methods: This is a cross-sectional study conducted at Mohammed V Military Hospital of Instruction, Rabat. Anthropometric measurements and biochemical analyses were performed using standard procedures Results: A total of 714 women aged 18–65 years participated in this study. The overall prevalence of vitamin D deficiency was 74.4%. Approximately 24% and 51% of women had severe and moderate vitamin D deficiency, respectively. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were inversely correlated with BMI in vitamin D-deficient subjects ( P = 0.036) and with parathyroid hormone 1–84 (PTH1-84) levels in the study sample ( P = 0.010). PTH1-84 concentrations were greater among overweight/obese individuals compared to their non-overweight peers ( P = 0.001) and tended to be higher among vitamin D-deficient women than vitamin D-sufficient women ( P = 0.053). Conclusion: This study showed a very high prevalence of vitamin D deficiency in this sample of Moroccan women. Lower serum 25(OH)D levels were associated with increased BMI in vitamin D-deficient women and with elevated PTH1-84 levels among the study sample. Although these findings come from a convenience sample of women that attended a nutrition clinic, they underscore the urgent need to develop public health interventions to improve women’s vitamin D status.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 87%

Vitamin D status and its relationship with obesity indicators in Moroccan adult women

et al. 2022

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“…In a study investigating the seasonal variability of vitamin D and PTH in obese children, vitamin D was found to be higher in summer than in autumn and winter in the obese and control groups. In addition, seasonal variability was not detected in the obese group in terms of PTH, while it was found to be high in the control group in autumn and spring months ( 3 ). Seasonal variation in vitamin D was evaluated in a study conducted in the UK that included 223 obese, overweight and normal weight adults ( 2 ).…”

Section: Discussionmentioning

confidence: 83%

“…It has been reported that vitamin D deficiency in obesity may be due to rapid metabolic clearance of vitamin D, large distribution volume and decreased bioavailability ( 1 , 2 ). Vitamin D synthesis starts in the skin with sunlight exposure and thus a further reason for vitamin D deficiency in obesity may be decreased cutaneous synthesis ( 3 ). Therefore, a seasonal difference is normally observed in vitamin D levels.…”

Section: Introductionmentioning

confidence: 99%

Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?

Küçükali¹,

Gülbahar²,

Özalkak³

et al. 2021

Jcrpe

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Objective: Free hormones are biologically more active in target tissues. Thus, measurement of vitamin D taking into account bioavailability and free vitamin D may be preferable, especially when evidence is contradictory, as in obese children. In order to assess bioavailablity and free vitamin D, using a previously reported formula, vitamin D-binding protein (VDBP) level was measured and VDBP polymorphisms were also evaluated because of variations in binding affinity. Methods: Eighty-four obese and 78 healthy children were included. Anthropometry, calcium, phosphorus, alkaline-phosphatase, parathyroid hormone (PTH), 25 hydroxyvitamin D [25(OH)D], bioavailable-free vitamin D, and VDBP concentration and polymorphism were evaluated in the whole group. Results: Obese girls had significantly higher PTH than normal weight girls (p=0.001). Regardless of gender, obese children had significantly higher concentrations of VDBP (p=0.008) and PTH (p=0.002). When samples taken in winter were analyzed, PTH and VDBP were found to be higher and bioavailable and free vitamin D lower in the obese group. There was no difference in terms of total vitamin D between groups during the winter season. Conclusion: While total, free, and bioavailable vitamin D in the obese group was similar to the control group in autumn, free and bioavailable vitamin D in the winter was lower in the obese than the control group. In addition, PTH was higher in the obese group in both autumn and winter. Therefore, more research is needed to evaluate the variability of free and bioavailable vitamin D according to body habitus, season and the effect any differences may have.

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“…After careful screening of 2803 full texts, we also excluded 2731 more studies because they evaluated the relationship between serum levels of 25(OH)D with an outcome other than anthropometric/adiposity indices, were clinical trials, animal or in vitro studies in design, editorial, and reviews, or the participants of the studies were unhealthy (with chronic diseases, such as diabetes, cancer, or chronic kidney disease). Ultimately, 72 studies ( 12 , 13 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , …”

Section: Resultsmentioning

confidence: 99%

Association of vitamin D levels with anthropometric and adiposity indicators across all age groups: a systematic review of epidemiologic studies

Abiri,

Valizadeh,

Ramezani Ahmadi

et al. 2023

Endocrine Connections

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Objectives: It has not been established whether vitamin D deficiency is associated with anthropometric state; therefore, this systematic review examined the relationship between serum vitamin D levels with anthropometrics and adiposity across different ages. Methods: Studies that examined vitamin D deficiency with adiposity measures in different age groups were searched in the PubMed, Scopus, EMBASE, and Google Scholar databases until November 2023. Two investigators independently reviewed titles and abstracts, examined full-text articles, extracted data, and rated the quality in accordance with the Newcastle-Ottawa criteria. Results: Seventy-two studies, with a total of 59,430 subjects, were included. Of these studies, 27 cross-sectional studies and one longitudinal study (with 25,615 participants) evaluated the possible link between 25(OH)D serum concentrations and anthropometric/adiposity indices in the pediatric population. Forty-two cross-sectional studies and two cohort investigations (with 33,815 participants) investigated the relationship between serum 25(OH)D levels and adiposity measures in adults and/or the elderly population. There is evidence supporting links between vitamin D deficiency and obesity, and revealed an inverse association between vitamin D and adiposity indicators, specifically in female subjects. However, the effects of several confounding factors should also be considered. Conclusion: Most published studies, most of which were cross-sectional, reported a negative association between vitamin D and female adiposity indicators. Therefore, serum vitamin D levels should be monitored in overweight/obese individuals.

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Are there any seasonal variations in 25-hydroxyvitamin D and parathyroid hormone serum levels in children and adolescents with severe obesity?

Cited by 5 publications

References 31 publications

Vitamin D status and its relationship with obesity indicators in Moroccan adult women

Vitamin D status and its relationship with obesity indicators in Moroccan adult women

Is Bioavailable Vitamin D Better Than Total Vitamin D to Evaluate Vitamin D Status in Obese Children?

Association of vitamin D levels with anthropometric and adiposity indicators across all age groups: a systematic review of epidemiologic studies

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