We have developed a microscopic model for antikaon absorption on two nucleons in nuclear matter. The absorption is described within a meson-exchange picture and the primary K − N interaction strength is derived from state-of-the-art chiral coupled channel meson-baryon interaction models. We took into account the medium modification of the K − N scattering amplitudes. We derived the K − N N as well as K − N optical potentials as functions of nuclear matter density including the real part of the K − N N potential. We calculated the K − single-and two-nucleon absorption fractions and branching ratios for various mesonic and non-mesonic channels. We have confirmed the crucial role of in-medium effects in our calculations. Our results are in very good agreement with available experimental data from old bubble chamber experiments as well as with the latest results from the AMADEUS collaboration. I = 0 resonance Λ(1405), which couples strongly to the πΣ channel giving rise to a sizable K − absorption. The theoretical description of the K − N interaction is currently provided by the chiral coupled channel meson-baryon interactions models [11][12][13][14][15] in which the Λ(1405) is generated dynamically. Parameters of these models are fitted to available low-energy K − N observables [16][17][18][19][20][21]. On the other hand, the interaction of antikaons with two and more nucleons lacks a solid theoretical description.A very important source of information about the K − -nucleus interaction is provided by kaonic atom experiments, in which the low-energy K − annihilates in the surface region of a nucleus, thereby probing the K − -nucleus potential at low nuclear densities close to threshold. The latest analysis of kaonic atom data by Friedman and Gal [22] showed that K − optical potentials based on the K − N scattering amplitudes derived from state-of-the-