Are the vascular complications of diabetes mellitus preceded by an altered thromboxane/prostacyclin plasmatic ratio?

Tomasi, Vittorio; Strano, A; Orlandi, Marina; Bartolini, G; Davı̀, Giovanni; Monti, Daniela; U, Taddeo; Zavagli, G

doi:10.1016/0306-9877(86)90070-8

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Changes In Eicosanoid Production By Platelets a N D Vessel W1

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“…Reviewing the altered TxA2/ PGI2 ratio in diabetes, Tomasi et al (1986) suggested that the changes may be due to one or a combination of the following…”

Section: Changes In Eicosanoid Production By Platelets a N D Vessel Wmentioning

confidence: 99%

Cardiovascular Sensitivity Changes to Eicosanoids in Rats With Experimentally Induced Diabetes Mellitus

Hodgson

Sikorski

King

1992

Clin Exp Pharma Physio

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This paper attempts to provide a short review of the evidence for: 1. Increased platelet production of thromboxane A2 and reduced vascular production of prostacyclin in the human and also animal models of diabetes. 2. Reduced depressor responsiveness to arachidonic acid of anaesthetized alloxan- and streptozotocin-induced diabetic rats. 3. Enhanced constrictor responsiveness to arachidonic acid in blood-perfused hindquarters of alloxan-induced diabetic rats. 4. Potentiation by the thromboxane A2-mimetic, U46619, of constrictor responses to 5-hydroxytryptamine in Krebs'-perfused hindquarters and kidneys of both control and alloxan-induced diabetic rats. 5. Alterations during diabetes in production of, and responsiveness to, eicosanoids may contribute to the cardiovascular changes which occur in this disease.

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“…Reviewing the altered TxA2/ PGI2 ratio in diabetes, Tomasi et al (1986) suggested that the changes may be due to one or a combination of the following…”

Section: Changes In Eicosanoid Production By Platelets a N D Vessel Wmentioning

confidence: 99%