Altered myocardial prostaglandin synthesis in spontaneously diabetic rats

Microcirculatory response of skin to benzoic acid and methyl nicotinate in patients with diabetes

“…A more likely explanation is that either the sensitivity of the cells synthesizing PGD 2 to BA and MN is increased or that the synthesis of PGD 2 in diabetes is enhanced. There is some evidence of increased synthesis observed in vas deferens and cardiac microsomes in diabetic rats [20,21]. As far as the role of other prostaglandins in the pathogenesis of diabetic complications is concerned, it is worth mentioning that the increased excretion of PGE 2 from the kidney of diabetic mice is connected with the renal vasodilatation and hyper®ltration seen in human diabetics [22].…”