Are Testosterone and BCL6 Critical Players in Cisplatin-Induced Nephrotoxicity in Rats?

Arabey, Amr Ahmed El

doi:10.4172/2161-0959.1000315

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…Cumulative effects of these events conclude in acute renal failure [ 5 ]. It has been found that nephrotoxicity due to Cisplatin can be monitored through diuretics and hydration regimens in many patients, but the frequency of Cisplatin nephrotoxicity still occurs in about one-third of patients undergoing Cisplatin treatment [ 32 ]. Amifostine is approved by the US Food and Drug Administration for Use in reducing progressive nephrotoxicity of repeated Cisplatin dosing in patients with advanced ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Nephroprotective effect of Apium graveolens L. against Cisplatin-induced nephrotoxicity

Naushad

Urooj

Ahmad

et al. 2021

Journal of Ayurveda and Integrative Medicine

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Background Cisplatin is extensively used in treating cancers, and its primary side-effect is nephrotoxicity. It accumulates in proximal convoluted tubules where it promotes cellular damage by oxidative stress, apoptosis, and inflammation, etc. In Unani medicine, Tukhm-e - Karafs (Apium graveolens L.) (TK) is mentioned in the literature to manage various kidney ailments due to its diuretic and deobstruent activities. Objective To investigate the nephroprotective effects of powder of TK in Cisplatin-induced nephrotoxicity in an animal model and to validate the Unani claim of its nephroprotective action. Material and methods In curative protocol, cisplatin (5 mg/kg body weight i.p) was administered on day one and powder of TK (500 and 1000 mg/kg p.o.) from the sixth day onwards for ten days. TK (500 and 1000 mg/kg p.o.) was given for ten days and Cisplatin (5 mg/kg body weight i.p) on day 11 in the protective model. At the end of the study, all the animals were sacrificed, and renal biochemical parameters were determined. KIM-1 level was also investigated in the kidney homogenate in conjunction with histopathological inspection of kidney tissues. Results Significant increase in serum creatinine and BUN, presence of mononuclear cell infiltration, tubular dilation and vacuolation in renal histopathology, and increased KIM-1 level confirmed the nephrotoxicity due to Cisplatin. TK's administration protects the kidney as suggested by the changes in biochemical renal function, decreased level of KIM-1, and improvement in histopathological changes. Conclusion The result advocated that TK prevented renal injury and maintained normal renal function in both models. It may be due to improved clearance of Cisplatin from kidney tubules and reduction in reactive oxygen species (ROS) produced by the inflammatory response.

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Section: Introductionmentioning

confidence: 99%