Are Sleep Disturbances a Risk for Chronic Traumatic Encephalopathy? Only the Shadow Knows

Quan, Stuart F.

doi:10.5664/jcsm.3516

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…While CTE can have a significant impact on the neurocognitive profile of patients, as well as lead to neurodegeneration, literature regarding the impact of CTE on sleep is sparse (McKee et al 2009). Although there has been some suggestion that OSA and insomnia may be risk factors for development of CTE, it is clear that poor sleep can negatively impact symptoms commonly seen in CTE, such as aggression, impulsivity and poor cognition (Quan 2014;Asken et al 2016). At this time, research efforts have been sparse and have yet to elucidate the potential impact of sleep on the development of CTE.…”

Section: Chronic Traumatic Encephalopathymentioning

confidence: 99%

A review of sleep disturbances following traumatic brain injury

Zuzuárregui

Bickart

Kutscher

2018

Sleep Science Practice

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Background: Sleep disorders are common following traumatic brain injury (TBI). Methods: We review the literature regarding sleep disturbances in the acute and chronic phase following TBI in both the adult and pediatric population. Results: Acute and chronic disruption of sleep commonly follows TBI and contributes to morbidity commonly seen post-injury in both adults and children. This includes the direct effect of TBI leading to sleep disruption, as well as sleep disorders resulting from TBI itself. Pre-TBI neurocognitive testing is important to determine a baseline prior to injury, while disrupted sleep can also prolong recovery after TBI. Early recognition of sleep disturbances post-injury can lead to earlier treatment and limit the sequelae of TBI, as well as assist in recovery. Conclusion: We suggest that evaluation for sleep disturbances following TBI is a critical component of post-TBI assessment and management.

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Section: Chronic Traumatic Encephalopathymentioning

confidence: 99%

A review of sleep disturbances following traumatic brain injury

Zuzuárregui

Bickart

Kutscher

2018

Sleep Science Practice

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“…82 Whether identifying and treating insomnia and obstructive sleep apnea in them can reduce the risk for later developing CTE and other dementias (such as Lewy Body Disease) is not yet known. 83 Of note, a 2020 study found probable REM behavior disorder in 32% of 247 men with CTE; more likely in those with more years of exposure to repeated head impacts especially those more likely to also develop Lewy body disease. 84…”

Section: Sleep and Sleep Disorders In Former Athletes With Chronic Tr...mentioning

confidence: 99%

Sleep/Wake Disorders After Sports Concussion: Risks, Revelations, and Interventions

Grigg-Damberger

2023

Journal of Clinical Neurophysiology

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Summary: Sleep-wake disturbances (SWDs) are among the most prevalent, persistent, and often disregarded sequelae of traumatic brain injury. Identification and treatment of SWDs in patients with traumatic brain injury is important and can complement other efforts to promote maximum functional recovery. SWDs can accentuate other consequences of traumatic brain injury, negatively affect mood, exacerbate pain, heighten irritability, and diminish cognitive abilities and the potential for recovery. The risk for sports injuries increases when athletes are sleep deprived. Sleep deprivation increases risk-taking behaviors, predisposing to injuries. SWDs are an independent risk factor for prolonged recovery after sports-related concussion. SWDs following sports-related concussion have been shown to impede recovery, rehabilitation, and return to preinjury activities.

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“…Moreover, post-TBI sleep disorders negatively impact the cognitive and emotional functions [17,24]. As one of the risk factors for chronic traumatic encephalopathy, PTSWDs contribute to the onset and exacerbation of symptoms, including poor cognition, aggression, and impulsivity [25,26]. Sleep disorders may be the cause of cognitive impairment and Alzheimer disease [27,28].…”

Section: Plain Language Summarymentioning

confidence: 99%

Identification of Imaging and Clinical Markers Predicting Chronic Sleep Disturbances After Traumatic Brain Injury in Adults

Ramezani

Yousefzadeh-Chabok

2018

Iran. J. Neurosurg.

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Background and Aim: We aimed to determine the prognostic imaging and clinical markers of chronic Post-Traumatic Sleep-Wake Disorders (PTSWDs) with a special focus on the early cognitive and executive dysfunctions following Traumatic Brain Injury (TBI). The prevalence rate of Post-Traumatic Psychiatric Disorders (PTPDs) in various sleep disorders was also investigated. Methods and Materials/Patients: In the present longitudinal study, 165 qualified patients with closed TBI were studied. Demographic, imaging and clinical characteristics of the subjects were recorded. The presence of acute post-traumatic cognitive deficits, anxiety, depression, and headache were measured by standard scales at discharge. Executive functioning was scored by the verbal fluency test. Several subjective questionnaires were applied to screen the chronic PTSWDs at 6 months after the onset of TBI. All variables were compared between the patients as well as those with and without PTSWDs using appropriate statistical tests. Results: Of 146 patients remaining in the follow-up study, 35% manifested PTSWDs, with insomnia and Excessive Daytime Sleepiness (EDS) as the most prevalent types. A poor executive functioning was observed in all PTSWDs patients, compared to those without PTSWDs, with only insomnia and hypersomnia patients demonstrating acute depression. Hypersomnia was also significantly related to bilateral brain contusion. The insomnia mostly comorbid with fatigue was predicted by mild injury, cortical lesions in the frontal lobe and acute severe headache. However, the patients who experienced the brain stem and diffusion lesions of right hemisphere were prone to EDS that was mainly accompanied by aggression. Conclusion: The predictive role of acute executive dysfunction has been clarified in this study. It is suggested that early neurorehabilitative interventions targeting the impaired neural circuits of executive functioning and mood processing may accelerate and facilitate the optimal neurofunctional recovery leading to minimizing the persistent sleep disturbances.

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Are Sleep Disturbances a Risk for Chronic Traumatic Encephalopathy? Only the Shadow Knows

Cited by 3 publications

References 20 publications

A review of sleep disturbances following traumatic brain injury

A review of sleep disturbances following traumatic brain injury

Sleep/Wake Disorders After Sports Concussion: Risks, Revelations, and Interventions

Identification of Imaging and Clinical Markers Predicting Chronic Sleep Disturbances After Traumatic Brain Injury in Adults

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