Are preoperative neutrophil/lymphocyte, platelet/lymphocyte, and platelet/neutrophil ratios markers in new-onset atrial fibrillation after coronary artery bypass grafting?

Abstract

This study aims to investigate the predictive value of platelet/neutrophil ratio (PNR) as a marker for postoperative atrial fibrillation (POAF) in addition to neutrophil/lymphocyte (NLR) and platelet/lymphocyte (PLR) measured in the preoperative period in patients who underwent coronary artery bypass grafting (CABG). Patients and methods:The data of a total of 122 patients (89 males, 33 females; mean age 63.2±9.19, range, 41 to 86 years) who underwent isolated CABG in our clinic and had no prior atrial fibrillation history between May 2018 and February 2020 were reviewed retrospectively. The patients were divided into two groups as those with and without POAF. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated.Results: Postoperative atrial fibrillation was detected in 36 of 122 patients. A significant difference was found in lymphocyte count (p=0.043), NLR (p=0.01), and PNR (p=0.048) in the patients who developed POAF. In the univariate logistic regression model, NLR was found to be an independent predictor for POAF development with 75% sensitivity, 53% specificity, 61.5% PPV, 67.9% NPV, and 64% accuracy (AUC: 0.646, p=0.01). In the POAF patients, the ROC analysis was performed to determine the diagnostic value of the PNR; however, no significant results were obtained. Conclusion:Our study results show an independent association between baseline NLR and POAF after CABG surgery.

Does Dexmedetomidine Reduce the Risk of Atrial Fibrillation and Stroke After Adult Cardiac Surgery? A Systematic Review and Meta-analysis of Randomized Controlled Trials

“…The incidence of POAF varied according to the cardiac surgery type and occur almost 30% after CABG, 30%-40% after valve replacement surgery, and 40%-60% after combined surgical procedures. 1 , 48 , 49 Our study showed the incidence of POAF was 12% in subgroup CABG, 37.5% in subgroup valve surgery, and 28.2% in subgroup combined surgery. Perioperative DEX was associated with a significant reduction of POAF in patients undergoing CABG ( P = .01).…”

“…Postoperative atrial fibrillation (POAF) is often observed in adult patients who underwent cardiac surgery with the reported incidence ranging from 15% to 40%. 1 POAF is associated with an increased incidence of postoperative stroke complications and results in not only prolonged hospital length of stay (LOS), but also increased hospital costs and mortality. 2 The mechanism of POAF is complex and remains poorly understood.…”

Multi-inflammatory index as a novel predictor of new-onset atrial fibrillation after off-pump coronary artery bypass grafting

“…Many inflammatory indicators such as Creactive protein (CRP), white blood cell (WBC), and interleukins (ILs), have been thoroughly investigated regarding POAF [9]. Moreover, various inflammatory parameters derived from a simple complete blood count (CBC) analysis such as neutrophil/lymphocyte ratio (NLR) [10,11], platelet/lymphocyte ratio (PLR) [11], and systemic immune-inflammation index (SII) [12][13][14] have been recently studied as possible predictive indicators of POAF after CABG.…”

The relationship between platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio and prognosis in carotid artery endarterectomy

“…High platelet levels and low lymphocyte levels are associated with chronic inflammation and a poor prognosis for cardiovascular diseases. [5] In particular, the PLR is a marker that predicts the severity of atherosclerosis, as well as being a marker of inflammation. [6] In the present study, we aimed to investigate the effects of PLR and NLR on the early period and oneyear follow-up results of patients undergoing carotid endarterectomy.…”