The relationship between platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio and prognosis in carotid artery endarterectomy

Baş, Tolga

doi:10.9739/tjvs.2022.1143

Cited by 1 publication

(3 citation statements)

References 17 publications

(18 reference statements)

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“…More importantly, the authors detected that PLR was an independent predictor of postoperative stroke after CEA. Bas et al 5 analyzed the effects of PLR and NLR on prognosis during one-year follow-up period after CEA. A total of 250 patients undergoing CEA were divided into two groups according to the occurrence of mortality during the follow-up, and the groups were compared with each other.…”

Section: Discussionmentioning

confidence: 99%

“…It was indicated that the aforementioned indices may be useful as prognostic biomarkers since they are associated with inflammation, thrombogenic activity, atherosclerotic processes, and subsequent plaque rupture. 4,5 Systemic immune-inflammation index (SII) is a newly developed marker that emerges based on platelet count and NLR (SII = platelet count × neutrophil/lymphocyte ratio) obtained from a CBC test and shows simultaneous immune and inflammatory status of patients. Elevated levels of SII were revealed to be associated with poor prognosis and reduction in life expectancy, and this novel index was demonstrated as a significant prognostic indicator in different types of cancer.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systemic immune-inflammation index for predicting poor outcome after carotid endarterectomy: A novel hematological marker

et al. 2022

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Objective To investigate the predictive role of systemic immune-inflammation index (SII) on postoperative poor outcome in patients undergoing carotid endarterectomy (CEA). Methods A total of 347 patients undergoing elective isolated CEA between March 2010 and April 2022 were included in this multicenter retrospective observational cohort and risk-prediction study and were divided into two groups as poor outcome group ( n = 23) and favorable outcome group ( n = 324). Poor outcome was defined as the presence of at least one of the complications within 30 days of surgery including stroke, myocardial infarction, and death. The patients' baseline clinical characteristics, comorbidities, and hematological indices were derived from the complete blood count (CBC) analysis, and perioperative data, outcomes, and complications were screened, recorded, and then compared between the groups. Multivariate logistic regression and receiver-operating characteristic (ROC) curve analyses were conducted following univariate analyses to detect the independent predictors of poor outcome as well as the cutoff values with sensitivity and specificity rates. Results A total of 23 patients out of 347 (6.6%) manifested poor outcome; and stroke, myocardial infarction, and death occurred in 13, 3, and 7 cases, respectively. There were no significant differences between the groups in terms of basic clinical characteristics, comorbidities, and perioperative data, except for lengths of intensive care unit and hospital stays. Although the median values of PLT, PLR, NLR, and SII of the poor outcome group were found to be significantly higher than the favorable outcome group in univariate analysis, only SII was detected to be a significant and independent predictor of poor outcome in multivariate logistic regression analysis (OR = 1.0008; 95% CI: 1.0004–1.0012; p = 0.002). ROC curve analysis revealed that SII of 1356 × 103/mm3 constituted the cutoff value for predicting poor outcome with 78.3% sensitivity and 64.5% specificity (AUC = 0.746; 95% CI: 0.64–0.851). Conclusions Our study revealed for the first time in the literature that SII significantly predicted poor outcome after CEA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systemic immune-inflammation index for predicting poor outcome after carotid endarterectomy: A novel hematological marker

et al. 2022

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The relationship between platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio and prognosis in carotid artery endarterectomy

Abstract: The relationship between platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio and prognosis in carotid artery endarterectomy.

Cited by 1 publication

References 17 publications

Systemic immune-inflammation index for predicting poor outcome after carotid endarterectomy: A novel hematological marker

Systemic immune-inflammation index for predicting poor outcome after carotid endarterectomy: A novel hematological marker

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