Are Patients with Perforated Peptic Ulcers Who are Negative for <i>Helicobacter pylori</i> at a Greater Risk?

Rasane, Rohit K; Horn, Christopher B.; Centeno, Adrian A Coleoglou; Fiore, Nicholas B; Barboza, Marlon Torres; Zhang, Qiao; Bochicchio, Kelly; Punch, L; Bochicchio, Grant V.; Ilahi, Obeid

doi:10.1089/sur.2018.249

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…11 Albumin that H. pylori negative group had lower serum albumin levels (2.97 ± 0.96 vs. 3.86 ± 0.91; p = 0.0001). 12 To determine the mechanism underlying the relationship between obesity and H. pylori gastritis, we examined the serum concentration of resistin in the same subject previously analyzed for the relationship of BMI with H. pylori gastritis, and found that the prevalence of H. pylori gastritis increased when resistin levels increased, using the Mann Whitney test found levels in patients with positive and negative H. pylori gastritis. The mean resistin in the group with H. pylori positive was higher with an average of 7.62 ng/mL while in the group with H. pylori negative with a mean of 3.23 ng/mL.…”

Section: Resultsmentioning

confidence: 99%

The Differences Level of Resistin between Positive and Negative Helicobacter pylori Gastritis and its Correlation with Nutritional Status

Satuti

Siregar

Lindarto

et al. 2020

InaJGHE

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Background: H. pylori gastritis can be related to people with obesity and metabolic syndrome. The mechanism underlying the relationship between them is suspected to be caused by adipocytokine called resistin. Objective: to analyze the difference level of resistin between positive and negative H. pylori gastritis patients and their relationship with nutritional status.Method: This cross sectional study was done in the Gastroenterology department of General Hospital Adam Malik, Medan, from May to October 2019. Patients with gastritis diagnosed by endoscopy underwent rapid urease test (RUT), resistin, albumin, hemoglobin tests, also body mass index (BMI) and waist circumference (WC) were measured.Results: Sixty gastritis patients found by endoscopic examination, 29 (48.33%) was H. pylori positive and 31 (51.67%) was negative. No significant differences were found between BMI, WC, and albumin against H. pylori gastritis with p values 0.099, 0.055, and 0.528, respectively. Hemoglobin was found significant with a p 0.009. The mean resistin in the positive H. pylori group was 7.62 ng/ml while the negative was 3.23 ng/ml, and statistically significant (p 0.001). There was a strong positive correlation between resistin levels with BMI and WC (BMI p 0.01, r 0.577; WC p 0.001, r 0.592).Conclusion: Resistin levels in gastritis with H. pylori positive are higher than H. pylori negative, body mass index and waist circumference have a strong relationship with resistin levels in patients with positive H. pylori gastritis, hemoglobin is lower in H. pylori positive than negative gastritis.

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Section: Resultsmentioning

confidence: 99%

The Differences Level of Resistin between Positive and Negative Helicobacter pylori Gastritis and its Correlation with Nutritional Status

Satuti

Siregar

Lindarto

et al. 2020

InaJGHE

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“…The clinical outcome of patients with perforated H pylori ‐negative PUD was worse in terms of length of hospital stay, requirement of intensive care unit stay, required days on mechanical ventilation, and 30‐day re‐admission rates, compared to patients with perforated H pylori ‐positive PUD. This was potentially explainable by different pathophysiologic concepts and better options of cure in H pylori ‐infected individuals . In general, the clinical outcome of bleeding PUD and its predictors is of interest.…”

Section: Gastric Diseasesmentioning

confidence: 99%

Review: Helicobacter pylori and non‐malignant upper gastrointestinal diseases

et al. 2019

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This review covers recent publications investigating the relationship between Helicobacter pylori infection and gastroesophageal reflux disease, Barrett's esophagus, eosinophilic esophagitis, peptic ulcer disease (PUD), H pylori gastritis, and functional dyspepsia. In the area of gastroesophageal reflux disease, new data suggest that reflux may have a role in the transmission of H pylori infection. In addition to several observational studies, data on alterations in esophageal physiology in patients with H pylori infection are presented. Further evidence for the inverse relationship between H pylori infection and Barrett's esophagus is available in the form of a meta‐analysis from the North American Barrett's and Esophageal Carcinoma Consortium. The relationship between H pylori infection and eosinophilic esophagitis remains uncertain. Although new data do not indicate a significantly lower prevalence of H pylori among patients with eosinophilic esophagitis, a meta‐analysis showed a 37% reduced risk of eosinophilic esophagitis among H pylori‐infected patients. Novel data are presented on the genetic variability of bacterial virulence factors and their relationship with PUD. We also report data on plasma biomarkers, which may detect progression to gastric cancer in H pylori‐associated PUD. A new meta‐analysis was published, which assessed the risk of PUD in low‐dose aspirin users with H pylori infection. Finally, we report on the ongoing attempts to stratify patients with gastritis using endoscopic methods when compared to standard biopsy examination.

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“…Iijima and his associates [ 112 ] reported that 45.9% of cases of peptic ulcers of the stomach and 29.6% of those of the duodenum were idiopathic. H. pylori -positive ulcer had better convalescence rates, better course, more positive prognosis, less hospital stay, less 30 days readmission, and fewer recurrence rates [ 113 , 114 ].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori and oral–gut microbiome: clinical implications

Elghannam,

Hassanien,

Ameen

et al. 2023

Infection

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More than half of the world’s population are colonized with H. pylori; however, the prevalence varies geographically with the highest incidence in Africa. H. pylori is probably a commensal organism that has been associated with the development of gastritis, ulcers, and gastric cancer. H. pylori alone is most probably not enough for the development of gastric carcinoma, but evidence for its association with the disease is high and has, therefore, been classified by the International Agency for Research on Cancer as a Class 1 carcinogen. Bacteroidetes and Fusobacteria positively coexisted during H. pylori infection along the oral–gut axis. The eradication therapy required to treat H. pylori infection can also have detrimental consequences for the gut microbiota, leading to a decreased alpha diversity. Therefore, therapy regimens integrated with probiotics may abolish the negative effects of antibiotic therapy on the gut microbiota. These eradication therapies combined with probiotics have also higher rates of eradication, when compared to standard treatments, and are associated with reduced side effects, improving the patient’s compliance. The eradication therapy not only affects gut microbiome but also affects the oral microbiome with robust predominance of harmful bacteria. However, there have been reports of a protective role of H. pylori in Barrett’s esophagus, esophageal adenocarcinoma, eosinophilic esophagitis, IBD, asthma, and even multiple sclerosis. Therefore, eradication therapy should be carefully considered, and test to treat policy should be tailored to specific communities especially in highly endemic areas. Supplementation of probiotics, prebiotics, herbals, and microbial metabolites to reduce the negative effects of eradication therapy should be considered. After failure of many eradication attempts, the benefits of H. pylori eradication should be carefully balanced against the risk of adverse effects especially in the elderly, persons with frailty, and intolerance to antibiotics.

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Are Patients with Perforated Peptic Ulcers Who are Negative for Helicobacter pylori at a Greater Risk?

Cited by 5 publications

References 29 publications

The Differences Level of Resistin between Positive and Negative Helicobacter pylori Gastritis and its Correlation with Nutritional Status

The Differences Level of Resistin between Positive and Negative Helicobacter pylori Gastritis and its Correlation with Nutritional Status

Review: Helicobacter pylori and non‐malignant upper gastrointestinal diseases

Helicobacter pylori and oral–gut microbiome: clinical implications

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