Are nutraceuticals the modern panacea? From myth to science

Minuz, Pietro; Velo, Giampaolo; Violi, Francesco; Ferro, Albert

doi:10.1111/bcp.13142

Cited by 20 publications

(19 citation statements)

References 27 publications

(43 reference statements)

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“…officinalis at the dosage of 3 g/day on metabolic factors in patients with chronic disease reported no serious side effects. Although, lack of the rigorous regulations in regard to the safety of herbal supplements has raised concerns that many available herbal supplements might be ineffective, given the fact that the nutraceutical manufacturers are less enforced than in the pharmaceutical sector to prove efficacy, safety, and quality of a marketed product (Izzo, Hoon‐Kim, Radhakrishnan, & Williamson, ; Minuz, Velo, Violi, & Ferro, ). However, in an animal study (Namjoo, MirVakili, & Faghani, ), very high doses of M .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double‐blind, clinical trial

Asadi

Shidfar

Safari

et al. 2018

Phytotherapy Research

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Melissa officinalis is a plenteous source of antioxidant flavonols and flavonoids that contain health‐promoting and antidiabetic properties, so this study was undertaken to provide the first assessment of the antidiabetic properties of hydroalcoholic extract of M. officinalis in type 2 diabetic patients. We did a randomized, placebo‐controlled trial which included 62 patients, receiving either M. officinalis capsules (700 mg/d; n = 31) or the placebo (n = 31) twice daily for 12 weeks. There were significant differences in serum FBS (P = 0.007), HbA1c (P = 0.002), β‐cell activity (P = 0.05), TG (P = 0.04), HDL‐c (P = 0.05), hs‐CRP (P = 0.001), and systolic blood pressure (P = 0.04) between the two groups at the end of the study; but total cholesterol, LDL‐c, insulin, and HOMA‐IR showed no significant changes between the groups. In M. officinalis group, there was a significant change in HDL‐c (P = 0.009) and QUICKI (P = 0.005) compared with baseline values. No adverse effects were observed. It seems that M. officinalis is safe and effective in improvement of lipid profile, glycemic control, and reduction of inflammation.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double‐blind, clinical trial

Asadi

Shidfar

Safari

et al. 2018

Phytotherapy Research

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“…Nutraceuticals undergo in vitro and in vivo pharmacokinetic, pharmacologic, therapeutic, safety, and head-tohead comparative effectiveness studies as do pharmaceuticals [20]. Clinical pharmacology studies of nutraceuticals are essential for nutraceutical development and delineation [22]. Nutraceuticals' use as prophylaxis against and treatment of pharmaceuticals' adverse effects is the subject of a separate paper, which also addresses nutraceuticals' inherent adverse effects.…”

Section: Nutraceuticalsmentioning

confidence: 99%

Nutraceuticals: Curative Integrative Cancer Treatment

Nwanodi¹

2017

Altern Integr Med

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Statement of Purpose: Although 75% of breast cancer patients may use integrative medicine, only 11.5% earlystage breast cancer patients believe integrative medicine has anticancer activity. The gap in users of and firm believers in integrative medicine indicates a need to increase awareness of integrative medicine's applicability to curative cancer treatment. As diet, nutraceuticals, and traditional Chinese medicine are used by up to 82% of cancer patients who use integrative medicine, this paper focuses on nutraceuticals. As female cancer patients are most likely to use integrative medicine, nutraceuticals specific to breast, cervical, endometrial, and ovarian cancer are reviewed.Methods: PubMed searches in September 2016 and January 2017, and accompanying hand searches were performed for English language, free full text articles published from 2012 onwards. Search terms were combinations of the key words: Homeopathy, phytochemicals, breast cancer, cervical cancer, endometrial cancer, ovarian cancer, cancer, prevention, treatment. Curative nutraceutical treatments were taken from these searches. Supplemental hand searches were performed as needed. Findings:Integrative nutraceutical therapies are based on biologic plausibility. Individual nutraceuticals are frequently comprised of numerous phytochemical types, and have multiple mechanisms of action. Agonistantagonist mechanisms are not exclusive to phytoestrogens, complicating which derivative or whole nutraceutical to use. Research on breast and cervical cancer inhibitors has seemingly outpaced that for endometrial and ovarian cancer. Breast cancer inhibitors include terpenes, isoflavones, organosulphurs, organoselenium compounds, and withanolides. Conclusion and Significance:Potential nutraceutical candidates for curative cancer treatment abound. Discerning which constituents, which extraction method, and which delivery method to use for an efficacious treatment is an essential, lengthy process. If nutraceuticals such as limonene and Kahalalide F move forward to Phase III trials a nutraceutical cancer treatment pipeline may be established. Withaferin-A and derivatives for breast and ovarian cancer appear to be the leading gynecologic cancer nutraceutical drug candidates.

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“…In Western countries, demand for nutraceuticals continues to grow, despite mounting criticism of the general lack of clinical evidence for many products, false claims of efficacy, concerns about quality, and issues surrounding self‐medication in cases of serious illness (Colalto, ; Grollman & Marcus, ; Izzo, ; Minuz, Velo, Violi, & Ferro, ).…”

Section: Introductionmentioning

confidence: 99%

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

Williamson

Liu

Izzo

2020

British J Pharmacology

201

173

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The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective of the nutraceuticals market, with a brief comparison with that in China, as an illustration of how individual health supplements increase and decrease in popularity in regional terms. Recent changes in sales patterns, mainly taken from the US market, are summarized and a selection of five newer products, which have not been subject to extensive recent review are profiled: astaxanthin, a carotenoid found in red algae, seafood, salmon and trout, as an antioxidant; cannabidiol, a non‐euphoric marijuana ingredient used as mood enhancer and for painful/inflammatory conditions; modified extracts of ginseng used in new indications including dementia and space travel; monk fruit, a non‐sugar high intensity sweetener and nigella seed, a popular food ingredient and Asian medicine, which has experienced an extraordinary rise in sales recently. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Are nutraceuticals the modern panacea? From myth to science

Cited by 20 publications

References 27 publications

Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double‐blind, clinical trial

Efficacy of Melissa officinalis L. (lemon balm) extract on glycemic control and cardiovascular risk factors in individuals with type 2 diabetes: A randomized, double‐blind, clinical trial

Nutraceuticals: Curative Integrative Cancer Treatment

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

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