Are neuromodulation interventions associated with changes in the gut microbiota? A systematic review

Korenblik, Vera; Brouwer, Marlies; Kőrösi, Anikó; Denys, Damiaan; Bockting, Claudi; Brul, Stanley; Lok, Anja

doi:10.1016/j.neuropharm.2022.109318

Cited by 8 publications

(7 citation statements)

References 80 publications

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“…Our present study delved into the composition of the gut microbiome in mice subjected to CRS modeling after EA treatment. Similar to other neuromodulation therapies ( Korenblik et al, 2023 ), EA had a partial effect on β-diversity (measured by Bray-Curtis) but did not influence α-diversity. Generally, the abundance of α-diversity was positively correlated with health status.…”

Section: Discussionsupporting

confidence: 56%

The impact of electroacupuncture on anxiety-like behavior and gut microbiome in a mouse model of chronic restraint stress

Bai,

Wei,

Tian

et al. 2023

Front. Behav. Neurosci.

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IntroductionElectroacupuncture (EA) is a beneficial physiotherapy approach for addressing neuropsychiatric disorders. Nevertheless, the impact of EA on the gut microbiome in relation to anxiety disorders remains poorly understood.MethodsTo address this gap, we conducted a study using a chronic restraint stress (CRS) mouse model to investigate the anti-anxiety outcome of EA and its influence on gut microbiota. Our research involved behavioral tests and comprehensive sequencing of full-length 16S rRNA microbiomes.ResultsOur findings revealed that CRS led to significant anxiety-like behaviors and an imbalance in the gut microbiota. Specifically, we identified 13 species that exhibited changes associated with anxiety-like behaviors. Furthermore, EA partially alleviated both behaviors related to anxiety and the dysbiosis induced by CRS.DiscussionIn summary, this study sheds light on the alterations in gut microbiota species resulting from CRS treatment and brings new light into the connection between EA’s anti-anxiety effects and the gut microbiota.

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Section: Discussionsupporting

confidence: 56%

The impact of electroacupuncture on anxiety-like behavior and gut microbiome in a mouse model of chronic restraint stress

Bai,

Wei,

Tian

et al. 2023

Front. Behav. Neurosci.

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“…The gut of stress-sensitive mice in our study contained more abundant Bacteroides, Alloprevotella, Helicobacter, Lachnoclostridium, Blautia, Roseburia, Colidextibacter and Lachnospiraceae NK4A136 than the gut of naïve controls. Bacteroides , Lachnoclostridium , Helicobacter, Blautia and Roseburia have been linked to stress response, anxiety and depression ( Chung et al, 2019 ; Kabeer et al, 2017 ; Radjabzadeh et al, 2022 ; Xu et al, 2021 , 2022 ; Zhang et al, 2022 ): increases in their abundance can induce intestinal inflammation and destroy the intestinal barrier, leading to infiltration by immune cells and changes in behavior ( Cheng et al, 2023 ; Korenblik et al, 2023 ; Ortega et al, 2023 ). The gut of stress-resistant mice in our study contained lower levels of these bacteria.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota regulate stress resistance by influencing microglia-neuron interactions in the hippocampus

He,

et al. 2024

Brain, Behavior, & Immunity - Health

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“…The results also showed that neuromodulation therapies cause modest changes in the gut microbiome. However, they did not result in changes in the variety of species or the differences across microbial communities [ 100 ].…”

Section: Discussionmentioning

confidence: 99%

Neuromodulation and the Gut–Brain Axis: Therapeutic Mechanisms and Implications for Gastrointestinal and Neurological Disorders

Aljeradat,

Kumar,

Abdulmuizz

et al. 2024

Pathophysiology

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The gut–brain axis (GBA) represents a complex, bidirectional communication network that intricately connects the gastrointestinal tract with the central nervous system (CNS). Understanding and intervening in this axis opens a pathway for therapeutic advancements for neurological and gastrointestinal diseases where the GBA has been proposed to play a role in the pathophysiology. In light of this, the current review assesses the effectiveness of neuromodulation techniques in treating neurological and gastrointestinal disorders by modulating the GBA, involving key elements such as gut microbiota, neurotrophic factors, and proinflammatory cytokines. Through a comprehensive literature review encompassing PubMed, Google Scholar, Web of Science, and the Cochrane Library, this research highlights the role played by the GBA in neurological and gastrointestinal diseases, in addition to the impact of neuromodulation on the management of these conditions which include both gastrointestinal (irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and gastroesophageal reflux disease (GERD)) and neurological disorders (Parkinson’s disease (PD), Alzheimer’s disease (AD), autism spectrum disorder (ASD), and neuropsychiatric disorders). Despite existing challenges, the ability of neuromodulation to adjust disrupted neural pathways, alleviate pain, and mitigate inflammation is significant in improving the quality of life for patients, thereby offering exciting prospects for future advancements in patient care.

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Are neuromodulation interventions associated with changes in the gut microbiota? A systematic review

Cited by 8 publications

References 80 publications

The impact of electroacupuncture on anxiety-like behavior and gut microbiome in a mouse model of chronic restraint stress

The impact of electroacupuncture on anxiety-like behavior and gut microbiome in a mouse model of chronic restraint stress

Gut microbiota regulate stress resistance by influencing microglia-neuron interactions in the hippocampus

Neuromodulation and the Gut–Brain Axis: Therapeutic Mechanisms and Implications for Gastrointestinal and Neurological Disorders

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