Gut microbiota regulate stress resistance by influencing microglia-neuron interactions in the hippocampus

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review

“…Furthermore, their hippocampal region exhibited heightened microglial activation, disrupted microglia-neuron interactions, and reduced synaptic plasticity. Fecal microbiota transplantation from stress-sensitive mice to naïve counterparts disrupted microglianeuron interactions and impaired synaptic plasticity in the hippocampus, resulting in depression-like behavior post-stress exposure [100]. These findings propose that the gut microbiota may modulate resilience to chronic psychological stress through the regulation of microglia-neuron interactions within the hippocampus.…”

“…The latest study conducted by He et al (2024) has revealed a correlation between stress resilience in mice and the composition of gut microbiota. Stress-resistant mice exhibited higher levels of Lactobacillus and Akkermansia, but lower levels of Bacteroides, Alloprevotella, Helicobacter, Lachnoclostridium, Blautia, Roseburia, Colidextibacter, and Lachnospiraceae [100].…”

“…The latest study conducted by He et al (2024) has revealed a correlation between stress resilience in mice and the composition of gut microbiota. Stress-resistant mice exhibited higher levels of Lactobacillus and Akkermansia, but lower levels of Bacteroides, Alloprevotella, Helicobacter, Lachnoclostridium, Blautia, Roseburia, Colidextibacter, and Lachnospiraceae [100]. In this study, mice sensitive to stress displayed increased gut permeability, heightened immune responses within the colon, and elevated serum levels of pro-inflammatory cytokines.…”