Are laryngeal squamous cell carcinoma incidence and patient mortality a function of ABO blood grouping? A retrospective study

Adam, Saliou; Wilson, Keith; Overholser, Stephen; Khabbaz, Eyad; Moreno, Katia; Patil, Yash

doi:10.1017/s0022215111002507

Cited by 12 publications

(16 citation statements)

References 7 publications

(17 reference statements)

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“…For salivary gland cancer patients also, blood group A was found in majority of the patients which is contrary to the results of Garrett JV et al, in which no significant relation was found between blood group and salivary cancer [25]. However, Laryngeal cancer was found to be more in blood Group B which is contradictory to the results by Adam SI et al, who showed a higher prevalence among patients with blood Group A [26]. No specific reason has been documented so far for the prevalence of specific blood groups among various head and neck cancers.…”

Section: Resultscontrasting

confidence: 72%

Relative Risk of Various Head and Neck Cancers Among Different Blood Groups: An Analytical Study

Singh¹

2014

JCDR

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Section: Resultscontrasting

confidence: 72%

Relative Risk of Various Head and Neck Cancers Among Different Blood Groups: An Analytical Study

Singh¹

2014

JCDR

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“…Our current large cohort study made up for the deficiencies in previous studies, and the results showed that blood group had no prognostic value. A similar non-significant association has also been reported in laryngeal cancer [9]. Two reasonable explanations may account for these non-significant results.…”

Section: Discussionsupporting

confidence: 75%

“…Relationship between the ABO blood group and prognosis have been reported in many tumor types, including breast cancer [4], pancreatic cancer [5, 6], esophageal squamous cell carcinoma [7, 8], laryngeal squamous cell carcinoma [9] and non-small cell lung cancer [10]. Seemingly, the ABO blood group may be a useful prognostic factor and it also plays an important role in NPC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Correlations between ABO Blood Group and Pre-Treatment Plasma Epstein-Barr Virus DNA in Patients with Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiotherapy

Peng

Chen

et al. 2016

PLoS ONE

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PurposeThe objective of this study is to assess the prognostic value of ABO blood group in nasopharyngeal carcinoma (NPC) treated by intensity-modulated radiotherapy (IMRT).Patients and MethodsWe retrospectively reviewed the data on 1397 patients with non-metastatic, newly diagnosed NPC treated using IMRT. Patient survival between different ABO blood groups were compared using log-rank test. Cox hazards model was adopted to establish independent prognostic factors.ResultsIn our study, the distribution of the A, B, AB and O blood groups was 26.6% (372/1397), 26.2% (366/1397), 5.2% (73/1397) and 42.0% (586/1397), respectively. The cut-off value of pre-treatment Epstein-Barr virus (EBV) DNA based on disease-free survival (DFS) was 1355 copies/ml (area under curve [AUC], 0.649; sensitivity, 0.76; specificity, 0.496) for the whole cohort. Estimated four-year DFS, overall survival (OS), distant metastasis-free survival (DMFS) and locoregional relapse-free survival (LRRFS) rates were 81.7%, 89.2%, 89.4% and 92.3% for blood group A; 82.1%, 89.3%, 89.0% and 92.0% for group B; 83.3%, 88.1%, 86.2% and 95.5% for group AB, 80.9%, 90.7%, 88.4% and 90.2% for group O (P > 0.05 for all rates). Multivariate analysis revealed ABO blood group was not an independent prognostic factor for DFS, OS, DMFS or LRRFS (P > 0.05 for all rates) after adjusting for plasma EBV DNA in either the whole cohort or subgroup analysis by gender.ConclusionsThe prognostic value of ABO blood group may be limited for patients with NPC in the era of IMRT, and no substantial correlation between ABO blood group and plasma EBV DNA was observed.

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“…Identification of novel prognostic factors to recognise patients at high risk is warranted. Recently, the associations between ABO blood group and survival have been evaluated in pancreatic cancer (Engin et al , 2012; Rahbari et al , 2012), locoregional renal cell carcinoma (Kaffenberger et al , 2012), triple-negative breast cancer (Yu et al , 2012) or breast cancer (Stamatakos et al , 2009; Gates et al , 2012), oesophageal squamous cell carcinoma (Nozoe et al , 2004), and laryngeal squamous cell carcinoma (Adam et al , 2012). …”

mentioning

confidence: 99%

Prognostic value of ABO blood group in southern Chinese patients with established nasopharyngeal carcinoma

OuYang

Mao

et al. 2013

Br J Cancer

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Background:ABO blood group is associated with aetiology of nasopharyngeal carcinoma (NPC); however, the effect of it on survival of patients diagnosed with NPC has not been explored.Methods:We retrospectively analysed two cohorts of southern Chinese patients with WHO histological type III: intensity-modulated radiotherapy (IMRT) cohort, 924 patients; and conventional radiotherapy (CRT) cohort, 1193 patients. Associations of ABO blood group with survival were estimated using Cox regression.Results:In IMRT cohort, we observed significant associations of blood type A with overall survival (OS) and distant metastasis-free survival (DMFS), compared with type O, after adjusting for prognostic factors. Compared with non-A blood types (B, AB, and O), type A patients had significantly lower OS and DMFS (adjusted hazard ratio (HR)=1.49, 95% CI 1.03–2.17, P=0.036; HR=1.68, 95% CI 1.13–2.51, P=0.011, respectively); similar results were obtained in CRT cohort. Subgroup analyses of the entire population showed that lower OS conferred by blood type A was not significantly modified by age, smoking status, drinking status, immunoglobulin A against Epstein–Barr virus viral capsid antigen (VCA-IgA) titre, or chemotherapy; however, lower OS was not observed in female patients or patients with early clinical stage disease.Conclusion:ABO blood group is associated with survival in NPC; patients with blood type A had significantly lower OS and DMFS than patients with non-A blood types.

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Are laryngeal squamous cell carcinoma incidence and patient mortality a function of ABO blood grouping? A retrospective study

Abstract: Although our findings show no association between blood group and five-year survival, these results are inconclusive, and warrant further study of the association between blood type and laryngeal (and other) head and neck cancers.

Cited by 12 publications

References 7 publications

Relative Risk of Various Head and Neck Cancers Among Different Blood Groups: An Analytical Study

Relative Risk of Various Head and Neck Cancers Among Different Blood Groups: An Analytical Study

Prognostic Correlations between ABO Blood Group and Pre-Treatment Plasma Epstein-Barr Virus DNA in Patients with Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiotherapy

Prognostic value of ABO blood group in southern Chinese patients with established nasopharyngeal carcinoma

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