Prognostic Correlations between ABO Blood Group and Pre-Treatment Plasma Epstein-Barr Virus DNA in Patients with Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiotherapy

Peng, Hao; Chen, Lei; Li, Wen Fei; Zhang, Yuan; Liu, Li Zhi; Liu, Tian; Lin, Ai Hua; Sun, Ying

doi:10.1371/journal.pone.0166194

Cited by 7 publications

(15 citation statements)

References 23 publications

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“…Recently, there is increasing evidence showing that the ABO blood group is involved in the pathophysiology of various diseases such as cardiovascular and neoplastic disorders. 7 , 8 The correlations of ABO blood group with survival have been evaluated in various types of malignancies, including nasopharyngeal carcinoma, 9 ovarian cancer, 10 , 11 colon cancer, 12 and breast cancer. 13 A risk of developing cancer of the pancreas, stomach, and pharynx has been shown using 1.6 million blood donors from Swedish and Danish populations.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of ABO blood group in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

Li¹,

Wu²,

Ma³

et al. 2018

TCRM

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BackgroundThe association of ABO blood group with prognosis of several malignancies has been established. However, its role in hepatocellular carcinoma (HCC) remains unclear.Patients and methodsIn this study, we investigated the prognostic role of ABO blood group in unresectable HCC patients receiving transarterial chemoembolization (TACE) as an initial treatment. Medical records of 2,611 HCC patients were collected, and clinical data of 282 unresectable HCC patients receiving TACE were ultimately analyzed retrospectively. A prognostic nomogram was generated for predicting 1-, 2-, and 3-year overall survival (OS) probability. A total of 114 (40.4%), 69 (24.5%), 64 (22.7%), and 35 (12.4%) HCC patients had blood groups O, A, B, and AB, respectively.ResultsThe median OS times for patients with blood groups O, A, B, and AB were 24, 23, 20, and 20 months, respectively. Patients with blood group AB (hazard ratio [HR]=2.050, 95% confidence interval [CI], 1.331–3.157, P=0.001) or group non-O (HR=1.479, 95% CI, 1.110–1.972, P=0.008) had a poorer OS than those with blood group O. The prognostic nomogram, with a c-index of 0.701, was modest in predicting OS of unresectable HCC patients.ConclusionPatients with non-O blood group, particularly blood group AB, had a worse OS compared with those having blood type O. ABO blood group can predict the prognosis in patients with unresectable HCC undergoing TACE as an initial therapy. Further external validation in larger cohorts is necessary to confirm their usefulness in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Prognostic role of ABO blood group in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

Li¹,

Wu²,

Ma³

et al. 2018

TCRM

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“…So these results may help to further confirm that A blood type may have no prognostic value in NPC. Peng et al 24 showed that ABO blood type was not an independent prognostic factor for DFS, OS, DMFS or LRFS after adjusting for plasma Epstein-Barr virus deoxyribonucleic acid (EBV-DNA). There might be some prognostic value in ABO blood type but offset by adjusting for plasma EBV-DNA.…”

Section: Discussionmentioning

confidence: 99%

“…The correlation between ABO blood type and NPC remains controversial. Some researches demonstrated the absence of an association between ABO blood type and NPC 22-24. Other studies indicated that the ABO blood type was related to NPC susceptibility, for instance A blood type increased risks, mainly in male patients 25-27.…”

Section: Introductionmentioning

confidence: 99%

O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area

Wang¹,

Zhou²,

Chen³

et al. 2019

J. Cancer

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Purpose : To identify the association between ABO blood type and the survivals in nasopharyngeal carcinoma patients. Patients and methods : We retrospectively analyzed 2439 consecutive non-metastasis nasopharyngeal carcinoma patients between January 2001 and December 2004 at the Sun Yat-sen University Cancer Center. Survival outcomes were compared using Kaplan-Meier method. Univariate and multivariate analysis was performed by Cox regression model. Chi-square test was performed to compare categorical variables. Results : In the whole patients, compared with non-O blood type (A, B, and AB) patients, O blood type patients had significantly lower 5-year distant metastasis-free survival (DMFS) (adjusted hazard ratio (aHR)= 1.268, 95% CI 1.010-1.592, P=0.041). Moreover, we observed in female patients, O blood type patients had significantly lower 5-year overall survival (OS), disease-specific survival (DSS) and DMFS than those with non-O blood type (aHR=1.495, 95% CI 1.032-2.165, P=0.034 for OS; aHR=1.566, 95% CI 1.054-2.328, P=0.026 for DSS; aHR=1.779, 95% CI 1.056-2.998, P=0.030 for DMFS). In male patients, there was no significant difference observed between O blood type patients and non-O blood type patients in any survival endpoints. Conclusion : O blood type was associated with an unfavorable DMFS in female patients with nasopharyngeal carcinoma in epidemic area, which might contribute to unfavorable OS and DSS in female patients, even contribute to a lower DMFS in the whole patients. It might be beneficial to predict metastasis so as to guide the treatment in female patients with nasopharyngeal carcinoma in epidemic area.

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“…Although early‐stage NPC can be cured in the majority of cases, numerous NPC patients are diagnosed with advanced stage, and NPC metastasis commonly contributes to an unfavorable prognosis . The 5‐year survival rates of NPC patients are 87% to 96% for stage I‐II disease and 67% to 77% for stage III‐IV disease . Given its complicated structure and high degree of radiation sensitivity, the primary therapeutic option for NPC is radiotherapy .…”

Section: Introductionmentioning

confidence: 99%

Inhibition of the Numb/Notch signaling pathway increases radiation sensitivity in human nasopharyngeal carcinoma cells

Shen

Zeng

2019

The Kaohsiung J of Med Scie

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Radiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells. NPC tissues and normal nasopharyngeal tissues were collected. To evaluate the regulatory effects of the Numb/Notch signaling pathway, NPC cells were subjected to radiotherapy and various doses of the Numb/Notch signaling pathway inhibitor gamma secretase inhibitor (GSI). Next, the expression of Notch and Numb proteins was determined in NPC tissues and normal nasopharyngeal tissues, and the correlation of Notch and Numb protein expression with the clinicopathological features of NPC tissues was analyzed.Then, the effect of radiotherapy on NPC cell survival rate, survival fraction, apoptosis rate, proliferation, migration, and invasion as well as Numb/Notch signaling pathwayrelated molecules was detected. The results demonstrated that the Numb/Notch signaling pathway was activated in NPC tissues. Following treatment with radiotherapy and GSI, the Numb/Notch signaling pathway was inhibited. In addition, the NPC cell survival rate, survival fraction, cell proliferation, migration, and invasion were decreased, whereas the colony number and apoptosis rate were increased. Following radiotherapy and GSI treatment, Numb expression was increased, whereas Notch1, Hes1, Jagged1, and c-Myc expression was decreased. However, the greatest difference was noted upon treatment with radiotherapy +15 μM GSI. The results reported in this study suggest that a high dose of the inhibitor of the Numb/Notch signaling pathway GSI increased the radiation sensitivity in human NPC cells.

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Prognostic Correlations between ABO Blood Group and Pre-Treatment Plasma Epstein-Barr Virus DNA in Patients with Nasopharyngeal Carcinoma Receiving Intensity-Modulated Radiotherapy

Cited by 7 publications

References 23 publications

Prognostic role of ABO blood group in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

Prognostic role of ABO blood group in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization

O Blood Type Is Associated with Unfavorable Distant-metastasis-free Survival in Female Patients with Nasopharyngeal Carcinoma: A Retrospective Study of 2439 Patients from Epidemic Area

Inhibition of the Numb/Notch signaling pathway increases radiation sensitivity in human nasopharyngeal carcinoma cells

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