Are goats naturally resistant to gastric Helicobacter infection?

Gueneau, Pulchérie; Fuenmayor, Jaheli; Aristimuño, Olga Carolina; Cedeño, Samandhy; Báez, Estalina; Reyes, Nelson; Michelangeli, Fabián A.; Domínguez-Bello, María Gloria

doi:10.1016/s0378-1135(01)00443-6

Cited by 13 publications

(9 citation statements)

References 30 publications

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“…Although it is highly prevalent in bovines (reference 88 and unpublished results), its involvement in gastric disease in cattle is presently unknown. In contrast, Helicobacter DNA was not detected in the abomasums of 70 goats, using a genus-specific PCR (88).…”

Section: Gastric Helicobacters Associated With Ruminantsmentioning

confidence: 91%

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

et al. 2009

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SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.

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Section: Gastric Helicobacters Associated With Ruminantsmentioning

confidence: 91%

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

et al. 2009

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“…A high prevalence of ''Candidatus Helicobacter bovis'' has also been reported in cattle from Venezuela (85 %) and Europe (80 %) however they were not detected in the abomasums of goats (Braun et al 1997;De Groote et al 1999b;Gueneau et al 2002;Gustafsson et al 2006). The involvement of ''Candidatus Helicobacter bovis'' in gastric disease in cattle remains unknown ).…”

Section: Candidatus and Unvalidated Species ''Candidatus Helicobactermentioning

confidence: 99%

The Family Helicobacteraceae

et al. 2014

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“…46 Although the majority of cheetahs were infected with H. heilmannii-like Helicobacter, 3 cheetahs (Nos. 3,17,21) in the current study were previously determined to be infected with an H. pylori-like Helicobacter. 54 No specific type of gastritis was present in these 3 cheetahs, and no differences were noted among cheetahs with the same type of gastritis, despite differing Helicobacter.…”

Section: Discussionmentioning

confidence: 99%

“…1, 2) or housed at 8 facilities throughout North America (Nos. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Gastric samples from 14 cheetahs were fixed in 10% neutral buffered formalin and processed routinely for histopathology.…”

Section: Histology and Leukocyte Immunohistochemistrymentioning

confidence: 99%

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Characterization of the Gastric Immune Response in Cheetahs (Acinonyx jubatus) WithHelicobacter-Associated Gastritis

2011

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Captive cheetahs have an unusually severe progressive gastritis that is not present in wild cheetahs infected with the same strains of Helicobacter. This gastritis, when severe, has florid lymphocyte and plasma cell infiltrates in the epithelium and lamina propria with gland destruction, parietal cell loss, and, in some cases, lymphoid follicles. The local gastric immune response was characterized by immunohistochemistry in 21 cheetahs with varying degrees of gastritis. The character of the response was similar among types of gastritis except that cheetahs with severe gastritis had increased numbers (up to 70%) of lamina proprial CD79aþCD21-B cells. CD3þCD4þ T cells were present in the lamina propria, and CD3þCD8aþ T cells were within the glandular epithelium. Lymphoid aggregates had follicular differentiation with a central core of CD79aþ/CD45Rþ B cells and with an outer zone of CD3þ T cells that expressed both CD4 and CD8 antigens. MHC II antigens were diffusely expressed throughout the glandular and superficial epithelium. No cheetah had evidence of autoantibodies against the gastric mucosa when gastric samples from 30 cheetahs with different degrees of gastritis were incubated with autologous and heterologous serum. These findings indicate that T-cell distribution in cheetahs is qualitatively similar to that in other species infected with Helicobacter but that large numbers of lamina propria activated B cells and plasma cells did distinguish cheetahs with severe gastritis. Further research is needed to determine whether alterations in the Th1:Th2 balance are the cause of this more plasmacytic response in some cheetahs.

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Are goats naturally resistant to gastric Helicobacter infection?

Cited by 13 publications

References 30 publications

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

The Family Helicobacteraceae

Characterization of the Gastric Immune Response in Cheetahs (Acinonyx jubatus) WithHelicobacter-Associated Gastritis

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