Are eyeblink responses to tone in the decerebrate, decerebellate rabbit conditioned responses?

Nordholm, Alan F.; Lavond, David G.; Thompson, Richard F.

doi:10.1016/s0166-4328(05)80236-0

Cited by 43 publications

(14 citation statements)

References 32 publications

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“…Kehoe and Macrae (2002) write that 4 s does not result in learning but make no claim about the minimum interval. A study that explicitly tested the possibility of obtaining conditioned blinks in rabbits with an interval of 10 s concluded categorically that this was not possible (Nordholm, Lavond, & Thompson, 1991). Yet, the Chen and Thompson study from the same lab employed an intertrial of only one second, by all accounts much too short to obtain conditioning in whole animals.…”

Section: Challenge Ii: Conditions Of Ltd Inductionmentioning

confidence: 99%

Classical conditioning of motor responses: What is the learning mechanism?

et al. 2013

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Section: Challenge Ii: Conditions Of Ltd Inductionmentioning

confidence: 99%

Classical conditioning of motor responses: What is the learning mechanism?

et al. 2013

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“…They suggested that cerebellar lesions remove tonic drive acting upon motor pathways mediating the NM response, and decerebrations restore the level of this tonic activity, thus allowing expression of CRs formed in circuitry outside the cerebellum. But Nordholm et al (1991) recently showed that the intertrial intervals used by Kelly et al (1990) do not support NMR conditioning in the intact rabbit. This finding raises the question whether responses driven by the CS in partially cerebellectomized/ decerebrate subjects are true CRs produced by an associative process.…”

Section: Output and Input Pathways Of Hvi And The Ansiform Lobementioning

confidence: 99%

The Effect of Kainic Acid Lesions of the Cerebellar Cortex on the Conditioned Nictitating Membrane Response in the Rabbit

Hardiman

Yeo

1992

Eur J of Neuroscience

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In previous studies we have shown that aspiration lesions centred on lobule HVI in the cerebellar cortex of rabbits produce a profound loss of conditioned nictitating membrane (NM) responses. Because aspiration lesions of the cerebellar cortex cause retrograde degeneration in precerebellar nuclei we tested in rabbits whether excitotoxic lesions of the cerebellar cortex that spare these precerebellar nuclei also cause a loss of conditioned NM responses. Following discrete injections of kainic acid into HVI and rostral regions of the adjacent folia of crus I and crus II, we observed an immediate loss of conditioned NM responses. Following extensive retraining several subjects showed a gradual recovery of conditioned responses. But subjects with the most complete lesions never recovered more than a few conditioned responses. Kainic acid lesions did not change ipsilateral unconditioned reflex responses to a range of stimulus intensities. The kainic acid injections caused obvious degeneration of Purkinje and granule cells but not of the precerebellar nuclei. We conclude that HVI and parts of crus I and crus II are essential for normal retention of conditioned NM responses.

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“…2), could be a result of the unusual short ITI used in the present study. There is some evidence that in animal studies an ITI from at least 10 s is necessary to establish stable conditioning (Nordholm, et al, 1991). However, successful eyeblink conditioning was demonstrated with shorter ITIs in humans.…”

Section: Introductionmentioning

confidence: 99%

Cerebellar and Hippocampal Activation During Eyeblink Conditioning Depends on the Experimental Paradigm: A MEG Study

et al. 2003

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SUMMARY KEYWORDSThe cerebellum and the hippocampus are key structures for the acquisition of conditioned eyeblink responses. Whereas the cerebellum seems to be crucial for all types of eyeblink conditioning, the hippocampus appears to be involved only in complex types of learning. We conducted a differential conditioning study to explore the suitability of the design for magnetencephalography (MEG). In addition, we compared cerebellar and hippocampal activation during differential delay and trace conditioning. Comparable conditioning effects were seen in both conditions, but a greater resistance to extinction for trace conditioning. Brain activation differed between paradigms: delay conditioning provoked activation only in the cerebellum and trace conditioning only in the hippocampus. The results reflect differential brain activation patterns during the two types of eyeblink conditioning.

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Are eyeblink responses to tone in the decerebrate, decerebellate rabbit conditioned responses?

Cited by 43 publications

References 32 publications

Classical conditioning of motor responses: What is the learning mechanism?

Classical conditioning of motor responses: What is the learning mechanism?

The Effect of Kainic Acid Lesions of the Cerebellar Cortex on the Conditioned Nictitating Membrane Response in the Rabbit

Cerebellar and Hippocampal Activation During Eyeblink Conditioning Depends on the Experimental Paradigm: A MEG Study

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