Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?

Vourli, Georgia; Pharris, Anastasia; Cazein, Françoise; Costagliola, Dominique; Dabis, François; Amo, Julia del; Delpech, Valérie; Díaz, Asunción; Girardi, Enrico; Gourlay, Annabelle; Gunsenheimer‐Bartmeyer, Barbara; Hernando, Victoria; Nikolopoulos, Georgios K.; Porter, Kholoud; Rosińska, Magdalena; Sabin, Caroline; Suligoi, Barbara; Supervie, Virginie; Wit, Ferdinand W. N. M.; Touloumi, Giota

doi:10.1097/qad.0000000000002034

Cited by 25 publications

(24 citation statements)

References 21 publications

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“…In this work, we cross-sectionally compared the prevalence of CVD risk factors and the estimated total CVD risk between AMACS and EMENO participants. AMACS includes the majority of the HIV-infected adults living in Greece, and it is representative of the PLHIV on care [35]. EMENO consists of a representative sample of the adult general population living in Ten-year risk of fatal and non-fatal CVD using the Framingham risk score (FRS) was calculated for the individuals >20 years whereas 10-year risk of fatal CVD using the Systematic Coronary Risk Evaluation (SCORE) for the non-diabetic individuals >20 years.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported contradictory results when comparing FRS risk in HIV-infected and uninfected individuals, with some reporting higher [44], some similar [22,45] and some even lower [46] risk in HIV-infected. It has been shown that the FRS equations underestimate CVD risk in PLHIV [35,47]. SCORE and FRS have been rarely compared in PLHIV.…”

Section: Hiv-infected Predicted % (95% Ci)mentioning

confidence: 99%

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Cardiovascular risk factors in HIV infected individuals: Comparison with general adult control population in Greece

Touloumi¹,

Kalpourtzi²,

Papastamopoulos³

et al. 2020

PLoS ONE

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Background Although combined antiretroviral therapy has substantially improved the prognosis of people living with HIV (PLHIV), mortality remains higher compared to the general population, mainly due to higher prevalence of non-HIV-related comorbidities, including cardiovascular diseases (CVD). We assessed the prevalence of CVD risk and its contributing factors in adult PLHIV versus general population controls in Greece.

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Section: Discussionmentioning

confidence: 99%

Section: Hiv-infected Predicted % (95% Ci)mentioning

confidence: 99%

Cardiovascular risk factors in HIV infected individuals: Comparison with general adult control population in Greece

Touloumi¹,

Kalpourtzi²,

Papastamopoulos³

et al. 2020

PLoS ONE

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“…The cohorts in our study were large, including national cohorts with near complete coverage of the diagnosed population, and were fairly representative (Supplementary Data 1) [35]. Nevertheless, estimates from cohorts with low coverage should be interpreted with caution.…”

Section: Discussionmentioning

confidence: 99%

The Human Immunodeficiency Virus Continuum of Care in European Union Countries in 2013: Data and Challenges

Gourlay

Noori

Pharris

et al. 2017

Clinical Infectious Diseases

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“…The probability of being included in the cohort given demographic characteristics was estimated; weights inversely proportional to the inclusion probability were generated. Details of the applied method have been recently published [ 14 ]. Stages 5 and 6 were then re-estimated using the weighted AMACS data and weighted estimates were compared to the unweighted ones.…”

Section: Methodsmentioning

confidence: 99%

HIV cascade of care in Greece: Useful insights from additional stages

et al. 2018

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BackgroundAiming to eliminate HIV infection, UNAIDS has set a global “90-90-90” target by 2020. We sought to construct a 6-stages HIV Cascade of Care (CoC) in Greece, overall and by risk group, to assess risk-group and stage-specific progress in achieving the UNAIDS target.Patients and methodsCombining data from the HIV/AIDS surveillance system and a population-based HIV cohort study, the CoC included: i) number of people living with HIV (PLHIV) by end of 2013; ii) proportion of PLHIV ever diagnosed; iii) proportion of diagnosed linked-to-care iv) proportion of linked-to-care ever initiating antiretroviral therapy (ART); v) proportion of treated who retained-in-care vi) proportion of those retained-in-care who were virally suppressed (≤200 copies/mL) at their last visit (01/07/2012-31/12/2013).ResultsIn 2013, 14147 PLHIV were in Greece. Overall, proportions of each stage in the cascade were: 78.4% diagnosed; 86% linked-to-care; 78.5% initiated ART; 86.4% retained-in-care, and 87.1% virally suppressed. Totally, 42.6% of all PLHIV were virally suppressed. The percentage diagnosed was lower among heterosexual men and women (heterosexuals) than in MSM (men who have sex with men) or PWID (people who inject drugs). Most MSM were linked to care (97.2% of diagnosed) while a substantial proportion of PWID were not (80.8% of diagnosed). Once treated, PWID remained in care in similar proportions to MSM. Unlike PWID, a high proportion of the retained in care MSM and heterosexuals achieved viral suppression.ConclusionsAt the end of 2013, we identified gaps in the HIV CoC in Greece, which differed across risk groups. Targeted interventions are critical in optimizing early diagnosis and timely linkage. A 6-stage CoC, stratified by risk group, can inform strategic public health planning in improving HIV treatment outcomes.

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Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?

Abstract: Supplemental Digital Content is available in the text

Cited by 25 publications

References 21 publications

Cardiovascular risk factors in HIV infected individuals: Comparison with general adult control population in Greece

Cardiovascular risk factors in HIV infected individuals: Comparison with general adult control population in Greece

The Human Immunodeficiency Virus Continuum of Care in European Union Countries in 2013: Data and Challenges

HIV cascade of care in Greece: Useful insights from additional stages

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