Are congenital anorectal malformations more frequent in newborns conceived with assisted reproductive techniques?

Midrio, Paola; Nogare, Chiara Dalle; Gianantonio, Elena Di; Clementi, Maurizio

doi:10.1016/j.reprotox.2006.05.004

Cited by 19 publications

(24 citation statements)

References 5 publications

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“…Some studies demonstrated higher rates of ARM children born after assisted reproductive techniques (Källén et al, 2005;Midrio et al, 2006;Reefhuis et al, 2009), and others showed a prolonged TTP in couples that had a child with the VACTERL association (Czeizel and Ludányi, 1985). We could not replicate these results, but we did find an association between ARM-VACTERL and established paternal fertility problems.…”

Section: Discussioncontrasting

confidence: 61%

Maternal and paternal risk factors for anorectal malformations: A Dutch case‐control study

Rooij

Wijers

Rieu

et al. 2010

Birth Defects Research

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Section: Discussioncontrasting

confidence: 61%

Maternal and paternal risk factors for anorectal malformations: A Dutch case‐control study

Rooij

Wijers

Rieu

et al. 2010

Birth Defects Research

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“…A similar situation exists for anal atresia, in which both the U.S. study and a small, Italian study (Midrio et al, 2006) found an increased OR-3.4 in the U.S. study and 13.3 in the Italian study. The U.S. study was based on 450 cases, 15 of which had ART; the Italian was based on 28 cases, four of which had IVF.…”

Section: Discussionsupporting

confidence: 55%

“…In a recent case-control study in the United States (Reefhuis et al, 2009), an association was found between assisted reproduction technology (ART) and septal heart defects, cleft lip, esophageal atresia, and anorectal atresia. The association with anorectal malformations had also been suggested in a small, Italian case-control study (Midrio et al, 2006). Special interest has been paid to the possible association between IVF and the occurrence of imprinting anomalies, which can cause rare conditions such as Angelman syndrome, Beckwith-Wiedemann syndrome, Prader-Willi syndrome, Russell-Silver syndrome, UPD 14 syndrome, pseudohypoparathyroidism 1b, transient neonatal diabetes mellitus, and maternal hypomethylation syndrome (Amor andHalliday, 2008, Manipalviratn et al, 2009).…”

Section: Introductionmentioning

confidence: 78%

Congenital malformations in infants born after in vitro fertilization in Sweden

Källén

Finnström

Lindam

et al. 2010

Birth Defects Research

165

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“…Specific associations have been reported for esophageal atresia, hypospadias (second or third degree), cleft palate, septal heart defects and the exstrophy-epispadias complex [10-12]. A few studies have also suggested an increased risk of anorectal malformations (ARM) [10,13-15]. ARM are rare birth defects concerning anus and rectum with largely unknown causes [16].…”

Section: Introductionmentioning

confidence: 99%

Assisted reproductive techniques and the risk of anorectal malformations: a German case-control study

Zwink

Jenetzky

Schmiedeke³

et al. 2012

Orphanet J Rare Dis

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BackgroundThe use of assisted reproductive techniques (ART) for treatment of infertility is increasing rapidly worldwide. However, various health effects have been reported including a higher risk of congenital malformations. Therefore, we assessed the risk of anorectal malformations (ARM) after in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI).MethodsData of the German Network for Congenital Uro-REctal malformations (CURE-Net) were compared to nationwide data of the German IVF register and the Federal Statistical Office (DESTATIS). Odds ratios (95% confidence intervals) were determined to quantify associations using multivariable logistic regression accounting for potential confounding or interaction by plurality of births.ResultsIn total, 295 ARM patients born between 1997 and 2011 in Germany, who were recruited through participating pediatric surgeries from all over Germany and the German self-help organisation SoMA, were included. Controls were all German live-births (n = 10,069,986) born between 1997 and 2010. Overall, 30 cases (10%) and 129,982 controls (1%) were born after IVF or ICSI, which translates to an odds ratio (95% confidence interval) of 8.7 (5.9–12.6) between ART and ARM in bivariate analyses. Separate analyses showed a significantly increased risk for ARM after IVF (OR, 10.9; 95% CI, 6.2–19.0; P < 0.0001) as well as after ICSI (OR, 7.5; 95% CI, 4.6–12.2; P < 0.0001). Furthermore, separate analyses of patients with isolated ARM, ARM with associated anomalies and those with a VATER/VACTERL association showed strong associations with ART (ORs 4.9, 11.9 and 7.9, respectively). After stratification for plurality of birth, the corresponding odds ratios (95% confidence intervals) were 7.7 (4.6–12.7) for singletons and 4.9 (2.4–10.1) for multiple births.ConclusionsThere is a strongly increased risk for ARM among children born after ART. Elevations of risk were seen after both IVF and ICSI. Further, separate analyses of patients with isolated ARM, ARM with associated anomalies and those with a VATER/VACTERL association showed increased risks in each group. An increased risk of ARM was also seen among both singletons and multiple births.

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Are congenital anorectal malformations more frequent in newborns conceived with assisted reproductive techniques?

Cited by 19 publications

References 5 publications

Maternal and paternal risk factors for anorectal malformations: A Dutch case‐control study

Maternal and paternal risk factors for anorectal malformations: A Dutch case‐control study

Congenital malformations in infants born after in vitro fertilization in Sweden

Assisted reproductive techniques and the risk of anorectal malformations: a German case-control study

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