Maternal and paternal risk factors for anorectal malformations: A Dutch case‐control study

Rooij, Iris A. L. M. van; Wijers, Charlotte H. W.; Rieu, P.N.M.A.; Hendriks, Hester S.; Brouwers, Marijn M.; Knoers, Nine V A M; Blaauw, Ivo de; Roeleveld, Nel

doi:10.1002/bdra.20649

Cited by 63 publications

(104 citation statements)

References 35 publications

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“…The exact genetics, perhaps in combination with environmental facts, remain ill defined [19]. Environmental studies have implicated paternal cigarette smoking and exhaust fume exposure as well as maternal obesity and diabetes as possible risk factors [20][21][22]. In addition, maternal exposure to industrial cleaning agents, multivitamin use and first trimester pyrexia have been implicated, although some of these findings could not be replicated in follow-up studies [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…Environmental studies have implicated paternal cigarette smoking and exhaust fume exposure as well as maternal obesity and diabetes as possible risk factors [20][21][22]. In addition, maternal exposure to industrial cleaning agents, multivitamin use and first trimester pyrexia have been implicated, although some of these findings could not be replicated in follow-up studies [21,22]. ARM reported in a first-or second-degree relative was most noteworthy in increasing ARM risk [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, maternal exposure to industrial cleaning agents, multivitamin use and first trimester pyrexia have been implicated, although some of these findings could not be replicated in follow-up studies [21,22]. ARM reported in a first-or second-degree relative was most noteworthy in increasing ARM risk [21,22]. Analysis by a large European collaboration, the European consortium on anorectal malformations (ARM-NET), further identified various maternal risk factors implicated in the fetal development of complicated ARMs associated with additional congenital abnormalities and vertebral, anal, cardiac, tracheoesophageal, renal, and limb defects (VACTREL) [23].…”

Section: Discussionmentioning

confidence: 99%

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Comparison in the incidence of anorectal malformations between a first- and third-world referral center

et al. 2015

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Purpose Aim of study was to evaluate the differences in incidence and presentation of anorectal malformations (ARMs) between selected Pediatric Surgery Divisions in the Republic of South Africa (ZAR) and Italy. Methods A retrospective cohort study involved analysis of clinical records of patients with ARM born between 2005 and 2012. Type of ARM, maternal age, birth weight, gestational age, presence of associated anomalies and delayed diagnosis were analyzed. Results 335 patients were included in this study. Of note, statistically significant differences between the African and European patient groups were observed in a male predominance in the ZAR patient population. In addition, female recto-perineal fistulas were diagnosed in significantly more Italian patients than in ZAR. Furthermore, a more advanced maternal age and a lower gestational age was noted in the European cohort with a minimal delay in initial diagnosis as opposed to the African counterpart. Both centers reported recto-perineal fistula as the most common malformation in male patients. Conclusion With the exception of perineal fistulas in females, the incidence of specific subtypes of ARMs was similar in the two groups. This may be of importance when extrapolating European study conclusion to the South African setting.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison in the incidence of anorectal malformations between a first- and third-world referral center

et al. 2015

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“…44 Other studies reported no significantly increased risk for several of the same outcomes. 24,26,35,54 The evidence of an association with birth defects other than neural tube defects, congenital heart defects, and oral clefts is therefore limited, as most defects were only investigated in 1 or 2 populations, and results seemed to be inconsistent between the studies.…”

Section: Fever and Health Effects In The Childmentioning

confidence: 99%

Systematic Review and Meta-analyses: Fever in Pregnancy and Health Impacts in the Offspring

2014

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BACKGROUND AND OBJECTIVE: Fever during pregnancy has been suspected to harm the developing fetus. However, until now, no systematic analysis of the available evidence has been undertaken to assess the impact of maternal fever on health outcomes in the child. The goal of this study was to systematically review evidence from epidemiologic studies on adverse health outcomes of the offspring in relation to exposure to maternal fever during pregnancy. METHODS: Systematic searches in PubMed, Web of Science, and the Cochrane Library were performed by using Medical Subject Headings, Boolean operators, and truncation, and references of references were reviewed. Cohort and case-control studies addressing health outcomes of prenatal fever exposure in humans were eligible for inclusion. Studies with no direct reference to fever, studies in selected populations (eg, preterm births), and studies published before 1990 were excluded. RESULTS: The available literature supported an increased risk of adverse offspring health in association with fever during pregnancy. The strongest evidence was available for neural tube defects, congenital heart defects, and oral clefts, in which meta-analyses suggested between a 1.5- and nearly 3-fold increased risk with fever exposure in the first trimester. We did not find strong evidence of a dose–response relationship, but there was some evidence that antipyretic medications may have a protective effect when used in relation to febrile episodes. CONCLUSIONS: We found substantial evidence to support the contention that maternal fever during pregnancy may negatively affect offspring health. The harmful effects seemed to cover both short- and longer-term health outcomes; however, for several outcomes, the evidence was insufficient to judge any association.

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“…In spite of the passed years the etiology of VACTERL association still remains a mystery for scientists [4] . Inherited factors, as well as environmental influences have been reported [5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

VACTERL association after infertility treatment - case report

Vedmedovska

Fodina

Polukarova

2016

IJDI

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VACTERL association includes at least three of the following congenital anomalies: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal and limb abnormalities. The objective of article is to demonstrate the perinatal outcome of VACTERL case in 38-year-old pregnant woman with a history of infertility. Pregnancy has occurred after intracytoplasmic sperm injection and embryoscopy before embryo transfer. The 1st trimester ultrasound demonstrated right forearm anomaly-aplasia of the right radius and thumb. The normal female karyotype (46XX) was obtained. Increasing amniotic fluid index and invisible stomach from 26 weeks confirmed the suspicion of VACTERL association. After reduction of 900 ml of amniotic fluids at 34 +4 weeks of gestation the symptoms of premature separation of placenta occurred. The newborn weight was 2,360 g according to Apgar scale assessment 5/5 at 1 st and 5 th minutes. Multiple reconstructive operations were performed after birth. Among them sigmostomy, gastrostomy, ezofageotraheal fistulae plastic, that were followed by bronchoscopy and fibrogastroscopy. VACTERL association is a sporadic phenomenon, but among ICSI pregnancies fetal structural abnormalities occurrence is slightly higher. Our case demonstrates that the different components included into VACTERL association can be visualized at different gestational age, allowing to suspecting this association later in the pregnancy and often not prior to delivery. The family must has to understand the consequences of complications and their impact on the quality of child life.

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Maternal and paternal risk factors for anorectal malformations: A Dutch case‐control study

Abstract: This study revealed potential risk factors for ARM, including fever during pregnancy, maternal overweight, use of multivitamins, paternal smoking, and occupational exposures, but a familial component seems important as well.

Cited by 63 publications

References 35 publications

Comparison in the incidence of anorectal malformations between a first- and third-world referral center

Comparison in the incidence of anorectal malformations between a first- and third-world referral center

Systematic Review and Meta-analyses: Fever in Pregnancy and Health Impacts in the Offspring

VACTERL association after infertility treatment - case report

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