Are computed tomography-based measures of specific abdominal muscle groups predictive of adverse outcomes in older cancer patients?

Looijaard, S.M.L.M.; Maier, Andrea B.; Voskuilen, A.F.; Zanten, T. Van; Bouman, D.E.; Klaase, Joost M.; Meskers, Carel G. M.

doi:10.1016/j.heliyon.2020.e05437

Cited by 6 publications

(11 citation statements)

References 35 publications

(55 reference statements)

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“…Muscle areas were determined by manually segmenting a region of interest (ROI) in the skeletal‐ and psoas muscles on the portovenous phase of the CE‐CT images. The CT slice at the level of the inferior part of L3 was chosen for analysis, which is conform the criteria of previous studies 7,13 . Subsequently, the skeletal muscles and psoas muscle areas determined from the segmented ROIs (mm 2 ) 7,13,14 .…”

Section: Methodsmentioning

confidence: 99%

“…The CT slice at the level of the inferior part of L3 was chosen for analysis, which is conform the criteria of previous studies 7,13 . Subsequently, the skeletal muscles and psoas muscle areas determined from the segmented ROIs (mm 2 ) 7,13,14 . Total abdominal muscle area (TAMA) was categorized into specific abdominal muscle groups; psoas muscles, back muscles (erector spinae and quadratus lumborum muscles), lateral muscle (external‐ and internal oblique and transversus abdominis) and rectus abdominis (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

“…Low skeletal muscle volume or psoas muscle volume is defined as sarcopenia, which can be relatively easily assessed using computed tomography (CT). Studies have shown that CT‐based measurements of abdominal muscles, including the psoas muscle, have the potential in predicting adverse outcome in surgical patients 12,13 …”

Section: Introductionmentioning

confidence: 99%

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Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

Kooten

Ravensbergen

Büseck

et al. 2023

Journal of Surgical Oncology

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Background Oncological sigmoid and rectal resections are accompanied with substantial risk of anastomotic leakage. Preoperative risk assessment and patient selection remain difficult, highlighting the importance of finding easy‐to‐use parameters. This study evaluates the prognostic value of contrast‐enhanced (CE) computed tomography (CT)‐based muscle measurements for predicting anastomotic leakage. Methods Patients that underwent oncological sigmoid and rectal resections in the LUMC between 2016 and 2020 were included. Preoperative CE‐CT scans, were analyzed using Vitrea software to measure total abdominal muscle area (TAMA) and total psoas area (TPA). Muscle areas were standardized using patient's height into: psoas muscle index (PMI) and skeletal muscle index (SMI) (cm2/m2). Results In total 46 patients were included, of which 13 (8.9%) suffered from anastomotic leakage. Patients with anastomotic leakage had a significantly lower PMI (22.1 vs. 25.1, p < 0.01) and SMI (41.8 vs. 46.6, p < 0.01). After adjusting for confounders (age and comorbidity), lower PMI (odds ratio [OR]: 0.85, 95% confidence interval [CI] 0.71–0.99, p = 0.03) and SMI (OR: 0.93, 95%CI 0.86–0.99, p = 0.02) were both associated with anastomotic leakage. Conclusion This study showed that lower PMI and SMI were associated with anastomotic leakage. These results indicate that preoperative CT‐based muscle measurements can be used as prognostic factor for risk stratification for anastomotic leakage.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

Kooten

Ravensbergen

Büseck

et al. 2023

Journal of Surgical Oncology

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“…The areas of visceral and subcutaneous fat, de ned as fat with CT values from − 200 HU to -50 HU, were determined, and the iliopsoas muscle area was measured using the software's arti cial intelligence engine. For the rectus abdominis, abdominal oblique, and erector spinae muscles, we manually traced the contours of the muscles at the lumbar L3 level and de ned the areas with CT values between − 29 HU and 150 HU as the muscles [10]. To obtain L/S values, we randomly selected two > 1-cm 2 regions on the right lobe of the liver and one > 1-cm 2 region on the spleen and measured the CT values of these regions.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…The modi ed versions of the mCHS and KCL criteria were used to de ne frailty [10]. The details of the mCHS evaluation are described in our previous report [6].…”

Section: Assessment Of Frailtymentioning

confidence: 99%

Erector spinae muscle area and the ratio of the computed tomography values of the liver and spleen are associated with frailty in older patients with diabetes: A cross-sectional study

Sato

Tamura

Murao

et al. 2023

Preprint

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Background Older patients with diabetes mellitus are more susceptible to frailty. Although some imaging markers of appendicular skeletal muscle mass obtained using dual-energy X-ray absorptiometry or computed tomography (CT) imaging can reflect frailty status, the association between imaging indices obtained by abdominal CT scans and frailty in older inpatients has not been reported. Methods A total of 151 older inpatients with diabetes mellitus (median age, 79 years; men, 42%) who underwent abdominal CT scans close to the admission were studied to examine the associations between abdominal CT indices and frailty. We used two frailty definitions: the modified Cardiovascular Health Study (mCHS) criteria and Kihon Checklist (KCL) criteria. Using the imaging analysis software SYNAPSE VINCENT®, we compared the areas of four truncal muscles (erector spinae, iliopsoas, rectus abdominis, and abdominal oblique muscles) and the ratio of the CT values of the liver and spleen (L/S) between frail and non-frail patients. The muscle areas that showed the strongest associations with frailty were also investigated in relation to grip strength and walking speed. Finally, we performed multivariate binominal logistic regression analysis to assess the independent associations of muscle areas and L/S with the prevalence of frailty. Results The prevalence of frailty defined by the mCHS and KCL criteria was 55% and 52%, respectively. The area of the erector spinae muscle was most significantly associated with frailty, and was significantly smaller in mCHS-defined frail patients of both sexes and in men with KCL-defined frailty. The erector spinae muscle area was also positively correlated with grip strength and walking speed. In contrast, the L/S ratio was higher in men with KCL-defined frailty. Multivariate logistic regression analyses revealed that the area of the erector spinae muscle was independently associated with mCHS-defined frailty in women, and the L/S ratio was associated with KCL-defined frailty in men. Conclusions The erector spinae muscle area and low liver fat could be indices of frailty in older patients with diabetes.

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Psoas muscle area is associated with prognosis in elderly patients with hip fracture

Byun,

Kim,

Koo

et al. 2024

J Bone Miner Metab

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Are computed tomography-based measures of specific abdominal muscle groups predictive of adverse outcomes in older cancer patients?

Cited by 6 publications

References 35 publications

Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

Erector spinae muscle area and the ratio of the computed tomography values of the liver and spleen are associated with frailty in older patients with diabetes: A cross-sectional study

Psoas muscle area is associated with prognosis in elderly patients with hip fracture

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