Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

Kooten, Robert T. van; Ravensbergen, Cor J.; Büseck, Sophie C D van; Grootjans, Willem; Peeters, Koen; Holman, Fabian A.; Heemskerk, Jan W T; Wouters, Michel W. J. M.; Cañete, Ana; Tollenaar, Rob A.E.M.

doi:10.1002/jso.27200

Cited by 2 publications

(1 citation statement)

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“…We have read with interest the article published by van Kooten et al 1 Anastomotic leakage is one of the most common and serious complications after colorectal cancer surgery. A study shows that the incidence of anastomotic leakage after colorectal surgery is 1%-24%, which can lead to patient death in severe cases and increase the chance of tumor recurrence, reducing the overall 5-year survival rate.…”

Section: To the Editormentioning

confidence: 99%

Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

Yang¹,

2023

Journal of Surgical Oncology

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Section: To the Editormentioning

confidence: 99%

Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

Yang¹,

2023

Journal of Surgical Oncology

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The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer after curative surgery

et al. 2023

BMC Cancer

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Background The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer has not been exhaustively investigated. Thus, the present study was performed to evaluate the effect of sarcopenia on the outcome of patients with left-sided colon and rectal cancer. Methods Patients with pathologically diagnosed stage I, II and III left-sided colon or rectal cancer who had undergone curative surgery between January 2008 and December 2014 were retrospectively reviewed. The psoas muscle index (PMI) identified by 3D-image analysis of computed tomographic images was the criterion used to diagnose sarcopenia. The cut-off value recommended by Hamaguchi (PMI value < 6.36 cm2/m2 for men and < 3.92 cm2/m2 for women) was adopted to confirm the diagnosis of sarcopenia. According to the PMI, each patient was divided into the sarcopenia group (SG) or the nonsarcopenia group (NSG). Then, the SG was compared with the NSG in terms of postoperative outcomes. Results Among the 939 patients included, 574 (61.1%) were confirmed to have preoperative sarcopenia. Initially, it was demonstrated that the SG was not significantly different from the NSG in terms of most baseline characteristics except for a lower body mass index (BMI) (P < 0.001), a larger tumour size (P < 0.001) and more weight loss (more than 3 kg in the last three months) (P = 0.033). The SG had a longer hospital stay after surgery (P = 0.040), more intraoperative blood transfusions (P = 0.035), and higher incidence of anastomotic fistula (P = 0.027), surgical site infection (SSI) (P = 0.037) and hypoalbuminemia (P = 0.022), 30-day mortality (P = 0.042) and 90-day mortality (P = 0.041). The SG had significantly worse overall survival (OS) (P = 0.016) and recurrence-free survival (RFS) (P = 0.036) than the NSG. Subsequently, Cox regression analysis revealed that preoperative sarcopenia was an independent predictive factor for worse OS (P = 0.0211, HR = 1.367, 95% CI: 1.049–1.782) and RFS (P = 0.045, HR = 1.299, 95% CI: 1.006–1.677). Conclusion Preoperative sarcopenia adversely affects the outcome of patients with left-sided colon and rectal cancer, and preoperative nutrition supplementation may help us improve their long-term and short-term outcomes.

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Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

Cited by 2 publications

References 38 publications

Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

Computed tomography‐based preoperative muscle measurements as prognostic factors for anastomotic leakage following oncological sigmoid and rectal resections

The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer after curative surgery

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