Are blood lipids risk factors for fracture? Integrative evidence from instrumental variable causal inference and mediation analysis using genetic data

Chen, Haimiao; Shao, Zhonghe; Gao, Yixin; Yu, Xinghao; Huang, Shuiping; Zeng, Ping

doi:10.1016/j.bone.2019.115174

Cited by 15 publications

(12 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a recent study applied two-sample Mendelian randomization (MR) methods to explore the causal association between blood lipid levels and fracture. They reported that HDL may have an indirect influence on fracture mediated by BMD [50]. According to what we have discussed above, the Fig.…”

Section: Discussionmentioning

confidence: 70%

Brachial-ankle pulse wave velocity is associated with the risk of osteoporosis: a cross-sectional evidence from a Chinese community-based cohort

et al. 2021

View full text Add to dashboard Cite

Background Association of arterial stiffness and osteoporosis has been well documented in elderly population. However, it is not clear whether they co-progress from the early stages through common mechanisms. The object of this study was to evaluate possible associations between arterial stiffness and osteoporosis by measuring brachial-ankle pulse wave velocity (baPWV) and the Osteoporosis Self-Assessment Tool for Asia (OSTA) index among a healthy population of Chinese aged 40 years and older. Whether baPWV can be used as a predictor of osteoporosis on OSTA was further assessed. Methods This study was cross-sectional in design. Of 3984 adults aged 40 years and older in the Yunyan district of Guiyang (Guizhou, China) who underwent both OSTA and baPWV measurements within 1 month, 1407 were deemed eligible for inclusion (women, 1088; men, 319). Results The mean baPWV was 1475 ± 302 cm/s (range,766–3459 cm/s). baPWV in 110 individuals with high risk of osteoporosis (OSTA index < − 4) was higher than that of individuals with non-high risk (1733 ± 461 cm/s vs. 1447 ± 304 cm/s, P < 0.001). OSTA index was negatively correlated with baPWV(ρ = − 0.296, P < 0.001) after adjusting for age, sex, body mass index, waist circumference, diastolic blood pressure, and creatinine clearance rate. baPWV was an independent predictor for the presence of high risk of osteoporosis (β = − 0.001, P < 0.001) and was consistent across age and sex subgroups, and the optimal baPWV cutoff value for predicting the presence of high risk of osteoporosis and fracture was 1693 cm/s. The AUC was 0.722 (95% confidence interval [CI], 0.667–0.777; P < 0.001, sensitivity of 52.8% and specificity of 83.6%). Conclusions We conclude that arterial stiffness measured by baPWV is well correlated with the severity of osteoporosis evaluated by OSTA. baPWV index may be a valuable tool for identifying individuals with risk of developing osteoporosis.

show abstract

Section: Discussionmentioning

confidence: 70%

Brachial-ankle pulse wave velocity is associated with the risk of osteoporosis: a cross-sectional evidence from a Chinese community-based cohort

et al. 2021

View full text Add to dashboard Cite

show abstract

“…However, a recent study applied two-sample Mendelian randomization (MR) methods to explored the causal association between blood lipid levels and fracture. They reported that HDL may have an indirect in uence on fracture mediated by BMD (39). According to what we have discussed above, the relationship between lipid levels in blood and the risk of fracture is currently controversial and the causal association remains elusive, further research is required.…”

Section: Discussionmentioning

confidence: 89%

Brachial-Ankle Pulse Wave Velocity is Associated With the Risk of Osteoporosis: A Cross-Sectional Evidence From A Chinese Community-Based Cohort

Tang

Zhang

Peng

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Association of arterial stiffness and osteoporosis has been investigated in Chinese population. However, the relationship between arterial stiffness and osteoporosis by measuring brachial-ankle pulse wave velocity (baPWV) and the Osteoporosis Self‐assessment Tool for Asia (OSTA) index is not established. The object of this study was to evaluate possible associations between baPWV and the risk of osteoporosis and bone fracture among a population of Chinese. Whether baPWV can be used as a predictor of osteoporosis on OSTA was further assessed. Methods: This study was cross-sectional in design. Of 3,984 adults aged 40 years and older in the Yunyan district of Guiyang (Guizhou, China) who underwent both OSTA and baPWV measurements within one month , 1,407 were deemed eligible for inclusion (women: 1,088, men: 319) . Results: The mean baPWV was 1,475 ± 302 cm/s (range,766-3,459cm/s). baPWV in 110 individuals with high risk of osteoporosis (OSTA index < -4) was higher than that of individuals with non-high risk (1,733 ± 461 cm/s versus 1,447 ± 304 cm/s, P<0.001). OSTA index was negatively correlated with baPWV（ρ = -0.296，P < 0.001）after adjusting for age, sex, body mass index, waist circumference, diastolic blood pressure and creatinine clearance rate. baPWV was an independent predictor for the presence of high risk of osteoporosis (β = -0.001, P < 0.001) and the optimal baPWV cut-off value for predicting the presence of high risk of osteoporosis and fracture was 1,693 cm/s. The AUC was 0.722 (95% confidence interval [CI], 0.667‐0.777; P < 0.001). Conclusions: We conclude that arterial stiffness measured by baPWV is well correlated with the severity of osteoporosis evaluated by OSTA. baPWV index may be a valuable tool for identifying individuals with risk of developing osteoporosis.

show abstract

“…Besides, Wang et al reaffirmed the above in an epidemiological study including 1791 Chinese participants aged ≥55 years that higher HDL-C levels were strongly associated with a higher risk of osteoporotic fracture, and this association remained stable in women [ 14 ]. Furthermore, Chen et al demonstrated a causal positive association between HDL-C and the risk of osteoporotic fracture in older adults in a genome-wide association study [ 19 ], which further suggests that we should consider cardiovascular beneficial HDL-C as a risk factor for osteoporosis. However, in a meta-analysis and systematic review, Ghorabi et al showed that lower HDL-C levels were associated with a higher risk of osteoporotic fractures [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Association of apolipoprotein A1 with osteoporosis: a cross-sectional study

Sun

2023

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Summary Higher levels of apolipoprotein A1 (ApoA1) were associated with higher risk of osteoporosis, which supports the argument that lipid metabolism is involved in bone metabolism. Background Although the current evidence shows that lipid metabolism and osteoporosis are closely related to cardiovascular disease, the association between ApoA1 and osteoporosis is still unknown. Therefore, the purpose of this study was to explore the relationship between ApoA1 and osteoporosis. Methods In this cross-sectional study, we included 7743 participants in the Third National Health and Nutrition Examination Survey. ApoA1 was regarded as an exposure variable and osteoporosis was considered as an outcome variable. Multivariate logistic regression analysis, sensitivity analysis, and receiver operator characteristic (ROC) were used to assess the association of ApoA1 with osteoporosis. Results Participants with higher ApoA1 had higher rates of osteoporosis compared to participants with lower ApoA1 (P < 0.05). Individuals with osteoporosis had higher levels of ApoA1 than individuals without osteoporosis (P < 0.05). In multivariate logistic regression analysis adjusted for age, sex, race, hypertension, diabetes, gout, hypotensive drugs, hypoglycemic drugs, systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein B, blood urea nitrogen, albumin, uric acid, hemoglobin A1c, alkaline phosphatase and total calcium, higher ApoA1 was strongly associated with higher risk of osteoporosis, whether as a continuous variable or a categorical variable [Model 3, OR (95% CI), P value: 2.289 (1.350, 3.881), 0.002 and 1.712 (1.183, 2.478), 0.004]. And after excluding individuals with gout, the correlation between them remained and was significant (P < 0.01). And ROC analysis also showed that ApoA1 could predict the development of osteoporosis (AUC = 0.650, P < 0.001). Conclusion ApoA1 was closely associated with osteoporosis.

show abstract

Are blood lipids risk factors for fracture? Integrative evidence from instrumental variable causal inference and mediation analysis using genetic data

Cited by 15 publications

References 66 publications

Brachial-ankle pulse wave velocity is associated with the risk of osteoporosis: a cross-sectional evidence from a Chinese community-based cohort

Brachial-ankle pulse wave velocity is associated with the risk of osteoporosis: a cross-sectional evidence from a Chinese community-based cohort

Brachial-Ankle Pulse Wave Velocity is Associated With the Risk of Osteoporosis: A Cross-Sectional Evidence From A Chinese Community-Based Cohort

Association of apolipoprotein A1 with osteoporosis: a cross-sectional study

Contact Info

Product

Resources

About