Are biomarkers correlated with recurrence patterns in patients with resectable gastric adenocarcinoma

Li, Gui Chao; Zhang, Zhen; Xue, Jun; Gu, Wei; Wang, Ya Nong; Li, Jin

doi:10.1007/s11033-011-0751-0

Cited by 14 publications

(8 citation statements)

References 25 publications

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“…However, our results showed that Ki-67 overexpression is related to recurrence and metastasis of MECs. Our study results are in accordance with Li et al who found that Ki-67 was correlated with lymph node metastasis and was not correlated with prognosis [24]. Our results support the model of carcinogenesis, with increased loss of control of cellular proliferation with the accumulation of genetic alterations in dysplastic lesions.…”

Section: Discussionsupporting

confidence: 91%

The prognostic significance of p63 and Ki-67 expression in myoepithelial carcinoma

Jiang

Cheng

et al. 2012

Head Neck Oncol

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BackgroundMyoepithelial carcinoma is a rare tumour. The clinical and biological behaviours of these tumours are variable. Although many factors have been evaluated as potential prognostic indicators, including clinical stage, site and size of the tumour, high proliferative activity, extensive invasion into the surrounding tissue, perineural permeation, the abnormal presence of nuclear DNA content, and marked cellular pleomorphism, there are no definite histological features that clearly correlate with their behaviour. Thus, conclusions regarding prognostic factors and ideal treatment may emerge as the number of investigated myoepithelial carcinoma cases accumulate.MethodsUsing immunohistochemistry, expression levels of p63 and Ki-67 were determined in 16 myoepithelial carcinoma samples and correlated with clinicopathological characteristics and patient prognosis.Resultsp63 expression was detected in six of the myoepithelial carcinoma tissues (37.5%) and Ki-67 was detected in five (31.3%). In addition, p63 and Ki-67 expression levels were associated with myoepithelial carcinoma recurrence and metastasis. All six patients with p63-positive expression died due to disease or cardiovascular disease (mean survival time = 50.5 months), and p63 expression was statistically significant with respect to survival (P = 0.01). Four patients with Ki-67-positive expression died due to disease or cardiovascular disease (mean survival time = 44.0 months); however, there was no statistically significant difference between Ki-67 expression and survival (P = 0.24).ConclusionsRecurrence and metastasis in myoepithelial carcinomas are more frequent in p63-positive and Ki-67-positive EMCs, and poor prognosis is associated with overexpression of p63.

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Section: Discussionsupporting

confidence: 91%

The prognostic significance of p63 and Ki-67 expression in myoepithelial carcinoma

Jiang

Cheng

et al. 2012

Head Neck Oncol

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“…EGFR expression correlates with disease recurrence and poorer survival [28]. This is substantiated by other studies as well in which EGFR overexpression is associated with an aggressive tumor and also with lymph node metastasis [39]. EGFR dimerization and activation leads to downstream upregulation of multiple processes that can result in cancer cell proliferation, reduced apoptosis, tumor-induced angiogenesis, and activation of invasion, dedifferentiation of cancer cells and enhanced metastatic potential [40,41].…”

Section: Discussionmentioning

confidence: 78%

Overexpression of Her1 (EGFR) in Gastric Cancer: A Saudi Regional Population Based Study

Ahmed¹,

Tamimi²

2012

OJPathology

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Background: Gastric cancer is one of the commonest malignant tumor worldwide. Its treatment remains a challenge for physicians. Epidermal growth factor receptor (EGFR) inhibitors have played a significant role in the management of solid malignancies including colorectal cancer. In this study we aimed to determine EGFR expression in gastric adenocarcinoma by standardized immunohistochemistry in a Saudi regional population based cohort and also to evaluate Ki-67 proliferating index and p-53 mutation status. Materials and Methods: Gastric carcinoma (GC) cases comprising surgical resection specimens and endoscopic biopsies, were selected, from the pathology archives of King Fahd Hospital of the University of Dammam (KFHU), spanning a time period of 6 years. The histological GC type was delineated according to Laurens classification and immunohistochemical (IHC) protein analysis for EGFR, Ki-67 and p-53 was carried out. Results: 42 cases of gastric GC were analyzed and EGFR overexpression was demonstrated in 4.76% of cases. Out of these 2.38% had membranous and the remaining demonstrated predominantly cytoplasmic along with focal membranous positivity. Ki-67 proliferation index ranged from moderate to high and and p-53 mutation status was negative in these cases. Conclusion: Low EGFR expressivity could be reflective of regional variation in cancer characteristics. The study also highlights the inadequacy of the currently employed gastric EGFR interpretation criterions and stresses on development of standardized and uniform EGFR evaluation protocols tailored for gastric needs.

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“…Of note, different patterns of recurrence correspond to different postoperative adjuvant therapy regimens. Hence, it is signi cant to predict the recurrence pattern to scheme personalized therapy [21] . Previously, Huang et al reviewed the medical records of 317 node-negative GC patients and the results showed that 51 patients had recurred, the population patients with locoregional recurrence, peritoneal seeding accounted for 51.0% separately and 21 (41.1%) patients had hematogenous metastasis [15] .…”

Section: Discussionmentioning

confidence: 99%

Recurrence in node-negative advanced gastric cancer with novel clinical and pathologic findings

Chen¹,

Xu²,

J³

et al. 2020

Preprint

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Abstract Background Node-negative gastric cancer patients carry a better prognosis than node-positive. However, a subset of these patients eventually died due to the high recurrence rate of recurrence. This study investigated the clinic-pathologic factors for recurrent patterns and prognosis. Methods The detailed medical records of 947 gastric cancer patients who underwent gastrectomy from the prospectively collected database of the Gastrointestinal Surgery Department of the First Affiliated Hospital of Zhejiang Chinese Medical University From January 2012 to December 2014 were analyzed retrospectively. Results Tumor size, tumor invasion, histological grading were the predictive factors for locoregional recurrence. Tumor invasion, histological grading, Lauren type and lymphatic vessel invasion resulted significantly in predicting peritoneal recurrence. Two parameters, tumor invasion and lymphatic vessel invasion, were significantly associated with hematogenous spread. The combinatorial biomarker of positive for both Ki67 and P53 was significantly associated with recurrence-free survival (RFS) (P = 0.037). Histological grading (P = 0.020), tumor invasion (P = 0.007) and lymphatic vessel invasion (P = 0.012) were independent factors related to overall survival (OS) in node-negative advanced gastric cancer patients. Conclusion The reported clinicopathologic factors for different recurrence patterns and the prognostic factors of RFS and OS should be considered to guide clinicians choose appropriate postoperative treatment strategy and construct individual follow-up schedule to improve prognosis of node-negative gastric cancer.

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Are biomarkers correlated with recurrence patterns in patients with resectable gastric adenocarcinoma

Cited by 14 publications

References 25 publications

The prognostic significance of p63 and Ki-67 expression in myoepithelial carcinoma

The prognostic significance of p63 and Ki-67 expression in myoepithelial carcinoma

Overexpression of Her1 (EGFR) in Gastric Cancer: A Saudi Regional Population Based Study

Recurrence in node-negative advanced gastric cancer with novel clinical and pathologic findings

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