Are Antifibrinolytic Agents Effective in the Treatment of Aneurysmal Subarachnoid Hemorrhage?

Eastin, Travis; Snipes, Carly; Seupaul, Rawle A.

doi:10.1016/j.annemergmed.2014.06.004

Cited by 8 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individuals who are most likely to comment are those with particularly strong (and often negative) opinions [23]. Further, although we treated each unique username as a unique person, it was possible that the same person may have used different usernames on different news sites, or even that persons were creating, and posting under, multiple accounts on the same news site to bolster the perceived support of a particular viewpoint.…”

Section: Limitationsmentioning

confidence: 99%

“…In addition, compared to other forms of social media such as Twitter, users can post more detailed opinions without restriction on the number of characters. The disadvantages include the fact that the population of online commenter do not necessarily reflect the general population, or HCWs, and that more negative voices tend to be more vocal online [23]. To understand Canadians’ perceptions of the seasonal influenza vaccination as a condition of service for HCWs, we evaluated readers’ responses to online newspaper articles after the BC policy was announced but before it was upheld in arbitration [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Examining Perceptions about Mandatory Influenza Vaccination of Healthcare Workers through Online Comments on News Stories

et al. 2015

View full text Add to dashboard Cite

BackgroundThe aim of this study was to understand online public perceptions of the debate surrounding the choice of annual influenza vaccinations or wearing masks as a condition of employment for healthcare workers, such as the one enacted in British Columbia in August 2012.MethodsFour national and 82 local (British Columbia) Canadian online news sites were searched for articles posted between August 2012 and May 2013 containing the words “healthcare workers” and “mandatory influenza vaccinations/immunizations” or “mandatory flu shots and healthcare workers.” We included articles from sources that predominantly concerned our topic of interest and that generated reader comments. Two researchers coded the unedited comments using thematic analysis, categorizing codes to allow themes to emerge. In addition to themes, the comments were categorized by: 1) sentiment towards influenza vaccines; 2) support for mandatory vaccination policies; 3) citing of reference materials or statistics; 4) self-identified health-care worker status; and 5) sharing of a personal story.Results1163 comments made by 648 commenters responding to 36 articles were analyzed. Popular themes included concerns about freedom of choice, vaccine effectiveness, patient safety, and distrust in government, public health, and the pharmaceutical industry. Almost half (48%) of commenters expressed a negative sentiment toward the influenza vaccine, 28% were positive, 20% were neutral, and 4% expressed mixed sentiment. Of those who commented on the policy, 75% did not support the condition to work policy, while 25% were in favour. Of the commenters, 11% self-identified as healthcare workers, 13% shared personal stories, and 18% cited a reference or statistic.InterpretationThe perception of the influenza vaccine in the comment sections of online news sites is fairly poor. Public health agencies should consider including online forums, comment sections, and social media sites as part of their communication channels to correct misinformation regarding the benefits of HCW influenza immunization and the effectiveness of the vaccine.

show abstract

Section: Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Examining Perceptions about Mandatory Influenza Vaccination of Healthcare Workers through Online Comments on News Stories

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Some comments suggested that it might be related to increased incidence of hydrocephalus and epilepsy [8,9]. Aiming to emphasize relevant therapeutic effects previously ignored due to small samples and to better focus on adverse events during the disease treatment course, we performed this analysis to assess the safety and effectiveness of TXA in patients with aneurysmal SAH.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of tranexamic acid in aneurysmal subarachnoid hemorrhage: A meta-analysis of randomized controlled trials

Liu

Xue

et al. 2021

The American Journal of Emergency Medicine

View full text Add to dashboard Cite

“…Recently, the ULTRA, a multicenter prospective, randomized, controlled, open-label trial with 955 participants from 8 treatment centers and 16 referring hospitals, assessed the effects of ultra-early tranexamic acid for aneurysmal SAH and showed a slight reduction in mortality but not in rebleeding after randomization and before aneurysm treatment as well as in the improvement of clinical outcome at 6 months [7]. Some comments suggest that it might be associated with increased incidence of hydrocephalus and epilepsy [8,9]. Aiming to emphasize relevant curative effects previously missed because of small samples and to better focus on adverse events during the disease treatment course, we conducted a meta-analysis to evaluate the e cacy and safety of tranexamic acid in the treatment of aneurysmal SAH.…”

Section: Introductionmentioning

confidence: 99%

Tranexamic Acid in Aneurysmal Subarachnoid Hemorrhage: A Meta-analysis of Randomized Controlled Trials

Liu

Ding

Xue

2021

Preprint

View full text Add to dashboard Cite

BackgroundTranexamic acid, as a hemostatic drug, is widely used to treat or prevent excessive blood loss. The efficacy of tranexamic acid in promoting good clinical outcomes, reducing mortality, and the occurrence of adverse events during treatment of aneurysmal subarachnoid hemorrhage remains unclear.MethodsPubMed, Web of Science, Embase, and The Cochrane Library were searched for randomized-controlled trials (from1980 to 2021) following strict inclusion and exclusion criteria. We performed STATA 16.0 and RevMan 5.3 for statistical analysis. Fixed-effect model (M-H method) and effect size RR (95% CI) were used as a pooled measure to combine the heterogeneous data. We also performed post hoc sensitivity analyses and conducted subgroup analyses to evaluate each outcome with low heterogeneity results.ResultsMeta-analysis showed that tranexamic acid was associated with reduced rebleeding(RR 0.72 [0.59, 0.87], p= 0.0008; I2:0%, p = 0.51). Tranexamic acid probably has no effect on good clinical outcome or mortality (RR 0.98 [0.92,1.04], p = 0.51; I2: 0%, p = 0.60; RR 1.01 [0.88,1.15], p=0.91; I2:0%, p = 0.51).TXA was associated with increased hydrocephalus (RR 1.13 [1.02, 1.24], p = 0.02; I2:0%, p = 0.61), DCI (RR 1.70 [1.34, 2.16], p < 0.0001; I2: 0%, p= 0.84) and seizure (RR 1.46 [1.00, 2.14], p= 0.05),The rate for thromboembolic complications were similar in both groups(RR 0.91 [0.63, 1.31], p = 0.62;I2: 0%, p = 0.73). There was significant drug related overall adverse events (RR 1.21 [1.11, 1.32], p < 0.0001; I2: 29%, p = 0.14).ConclusionsIn patients with aneurysmal subarachnoid hemorrhage, these findings indicate that it does not support the routine use of TXA.

show abstract

Are Antifibrinolytic Agents Effective in the Treatment of Aneurysmal Subarachnoid Hemorrhage?

Abstract: Antifibrinolytic agents for the treatment of patients with aneurysmal subarachnoid hemorrhage may decrease rebleeding but appear to increase cerebral ischemia and do not reduce mortality or severe disability.

Cited by 8 publications

References 4 publications

Examining Perceptions about Mandatory Influenza Vaccination of Healthcare Workers through Online Comments on News Stories

Examining Perceptions about Mandatory Influenza Vaccination of Healthcare Workers through Online Comments on News Stories

Efficacy and safety of tranexamic acid in aneurysmal subarachnoid hemorrhage: A meta-analysis of randomized controlled trials

Tranexamic Acid in Aneurysmal Subarachnoid Hemorrhage: A Meta-analysis of Randomized Controlled Trials

Contact Info

Product

Resources

About