Arctiin alleviates functional constipation by enhancing intestinal motility in mice

Abstract

Functional constipation (FC), a common symptom that is primarily associated with intestinal motility dysfunction, is a common problem worldwide. Arctiin (Arc) is a lignan glycoside isolated from the Chinese herbal medicine Arctium lappa L., which is a health food in China.

Effects of Bacillus coagulans TBC169 on gut microbiota and metabolites in gynecological laparoscopy patients

“…According to previous research, in rodents, the degree of insufficient gastrointestinal motility or intestinal obstruction was proportional to the degree of intestinal handling and inflammation; and the down-regulation of inflammation in the colon was associated with promoting colon contraction and reducing intestinal transit time ( Kalff et al, 1998 ; Wang et al, 2023 ). In humans, although minimally invasive surgery such as laparoscopy has limited handling of the intestine, it still causes transient inflammation and delays the recovery of gastrointestinal motility ( The et al, 2008 ).…”

Qi Lang formula relieves constipation via targeting SCF/c-kit signaling pathway: An integrated study of network pharmacology and experimental validation

“…Rhythmic slow waves of gastrointestinal muscle contraction are mediated by a variety of cell types, including smooth muscle cells, enteric neurons, telocytes, and ICC [ 29 ]. ICC mediates nerve and smooth muscle cells and regulates the transmission of neuromuscular signals, thereby controlling the contraction and peristalsis of the corresponding digestive tract smooth muscle [ 30 ]. Abnormalities in the number and structure of ICCs are associated with some gastrointestinal motility disorders [ 29 ], such as functional dyspepsia (FD) [ 31 ], intestinal obstruction [ 32 ], Hirschsprung disease (HSCR) and constipation [ 33 , 34 ].…”