Arecoline alleviated loperamide induced constipation by regulating gut microbes and the expression of colonic genome

Xu, Meng; Wang, Wenjuan; Su, Shunyong; Li, Wanggao; Hu, Xiaosong; Zhang, Jiachao

doi:10.1016/j.ecoenv.2023.115423

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…Arecoline intake leads to intestinal damage by stimulating the release of IL-6 and IL-1β. In another study, arecoline demonstrated an ameliorative effect on intestinal damage induced by constipation (Xu et al, 2023b). By measuring symptoms related to constipation, intestinal microbiota, short-chain fatty acid content in the cecum, and gene expression in the colon, the impact of arecoline on constipation was explored.…”

Section: Omics and Bioactivity Of Anmentioning

confidence: 99%

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

Sun,

Feng,

Hou

et al. 2024

Front. Pharmacol.

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Areca nut (AN), the fruit or seed of Areca catechu Linn, has many uses, including chewing and medicinal purposes. It has sparked worries about health due to the presence of alkaloids. Chewing AN may have a variety of negative consequences; however, the medicinal use of AN has no notable adverse effects. To completely understand and effectively use AN, researchers have investigated its chemical makeup or biological activity, analyzed the variations between different AN species and different periods, and improved extraction and processing procedures. Today, an increasing number of researchers are exploring the underlying reasons for AN variations, as well as the molecular mechanisms of biosynthesis of chemical components, to comprehend and change AN at the genetic level. This review presents an overview of the clinical study, pharmacology, and detection of the main bioactive components in AN, and the main factors influencing their content, delving into the omics applications in AN research. On the basis of the discussions and summaries, this review identifies current research gaps and proposes future directions for investigation.

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Section: Omics and Bioactivity Of Anmentioning

confidence: 99%

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

Sun,

Feng,

Hou

et al. 2024

Front. Pharmacol.

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“…Also, some research studies 17 , 18 have shown that arecoline is a muscarinic acetylcholine receptor agonist, with cholinergic effects. However, research on arecoline has predominantly focused on medical applications 19 – 21 , with limited exploration in agriculture. Thus, a thorough investigation into arecoline’s insecticidal potential is crucial for fully leveraging arecoline plant resources and discovering new lead compounds for botanical insecticides.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and evaluation of novel arecoline-linked amino acid derivatives for insecticidal and antifungal activities

Pang,

Xu,

et al. 2024

Sci Rep

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A series of arecoline derivatives with amino acid moieties were designed and synthesised using an acylamide condensation strategy, taking arecoline as the foundational structure. The insecticidal efficacy of these compounds against Aphis craccivora and Tetranychus cinnabarinus was evaluated. Notably, derivatives 3h and 3i demonstrated superior insecticidal activity compared with arecoline. Additionally, 3h and 3i showed good fungicidal effectiveness against two types of plant fungi. Moreover, molecular docking analyses suggested that 3h and 3i could affect the nervous systems of A. craccivora and T. cinnabarinus by binding to neuronal nicotinic acetylcholine receptors. These findings suggest that compounds 3h and 3i represent promising leads for further development in insecticide and fungicide research.

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Arecoline alleviated loperamide induced constipation by regulating gut microbes and the expression of colonic genome

Cited by 2 publications

References 43 publications

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

Design, synthesis, and evaluation of novel arecoline-linked amino acid derivatives for insecticidal and antifungal activities

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