Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages

Hyam, Supriya R.; Lee, Inah; Gu, Wen; Kim, Kyung-Ah; Jeong, Jin-Ju; Jang, Se-Eun; Han, Myung Joo; Kim, Dong-Hyun

doi:10.1016/j.ejphar.2013.01.014

Cited by 136 publications

(93 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results indicate that berberine has an effect on inhibiting the M1 and M2 polarization of M s in vitro and may play a regulatory role in the dynamic balance of M1/M2 phenotype. (66) The similar results were found in many compounds or CM prescription, such as curcumin, (67) arctigenin, (68) and Xuebijing Injection ( ). (52) Importantly, CMM can act in a dual-regulatory function in the in ammatory reaction depending on the specific physiological or pathological processes and the tissues involved.…”

Section: Recruitment and Activation Of Tamssupporting

confidence: 63%

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Sun

Gao

et al. 2017

Chin. J. Integr. Med.

View full text Add to dashboard Cite

Infiltration of the tumor microenvironment (TME) by immune and inflammatory cells is involved in promoting tumorigenesis, tumor progression, local invasion and metastasis.(1) Tumor-associated macrophages (TAMs), a prominent and abundant inflammatory component of solid and hematological malignancies, express a pro-and anti-tumor effect in all stages of carcinogenesis. Asian region. According to the theory of Chinese medicine (CM) and its practice, some Asian region. According to the theory of Chinese medicine (CM) and its practice, some prescriptions of CM regulate the body's internal environment possibly including the prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment (TME). Here we brie y summarize the pivotal remodeling the tumor microenvironment (TME). Here we brie y summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasis effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasis and immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antiand immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, tumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy. and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy.

show abstract

Section: Recruitment and Activation Of Tamssupporting

confidence: 63%

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Sun

Gao

et al. 2017

Chin. J. Integr. Med.

View full text Add to dashboard Cite

show abstract

“…The inflammatory response in the injured liver has been considered to activate HSCs proliferation (King and Goodell, 2011;Schwabe et al, 2003). As a potent anti-inflammatory agent, ATG could exert its effects on lipopolysaccharide (LPS)-stimulated murine macrophages in vitro, colitis in mice and experimental glomerulonephritis in rats (Cho et al, 2002;Hyam et al, 2013;Wu et al, 2009;Zhao et al, 2009). In the present study, the effects of ATG on the proliferation of activated HSCs and underlying mechanisms were explored.…”

Section: Discussionmentioning

confidence: 99%

The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: Persistent p27Kip1 induction by interfering with PI3K/Akt/FOXO3a signaling pathway

Wang

et al. 2015

European Journal of Pharmacology

View full text Add to dashboard Cite

“…Later, it has been demonstrated that PI3K signaling also participates in several macrophage functions, including recruitment and invasion (Khan et al , 2013, Qin et al , 2013 as well as inflammatory activation (Deng et al , 2013, Hyam et al , 2013. Studies of mice lacking class IB PI3K, p110γ, have shown that this isoform is essential for PIP 3 production and Akt activation in neutrophils and macrophages, since these animals display impaired migration of these inflammatory cells in response to endogenous chemoattractants (Hirsch et al , 2000, Jones et al , 2003, Li et al , 2000.…”

Section: Pi3k Function Is Required For Inflammatory Cell Recruitmentmentioning

confidence: 97%