Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Pu, Weiling; Sun, Li; Gao, Xiumei; Rüegg, Curzio; Cuendet, Muriel; Hottiger, Micheal O.; Zhou, Kun; Miao, Lin; Yun-sha, Zhang; M, Gebauer

doi:10.1007/s11655-017-2974-y

Cited by 4 publications

(2 citation statements)

References 96 publications

(92 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical use of TCM to treat tumors has many advantages [40,41]. For example, Fu Zheng and exorcism therapies are the main TCM treatments for tumors [42,43], and Fu Zheng treatment has been shown to improve immune function [26,44,45].…”

Section: Discussionmentioning

confidence: 99%

Antitumor Effect of IL-12 Gene-modified Bone Marrow Mesenchymal Stem Cells Combined With Fuzheng Yiliu Decoction in an in Vivo Glioma Nude Mouse Model

Xie

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Glioma is a complex cancer with a high morbidity and high mortality. Bone marrow mesenchymal stem cells (BMSCs) have shown promise as an excellent cell/drug delivery vehicle for gene-targeted therapy; however, maintaining genetic stability and biological activity remains difficult. Furthermore, whether BMSCs support or inhibit tumor growth remains debated. This study investigated whether a traditional chinese medicine fomular, Fuzheng Yiliu decoction (FYD) had a synergistic antitumor effect with IL-12 gene-modified BMSCs in glioma-bearing nude mice.Methods: The lentivirus-mediated IL-12 gene was transfected into primarily cultured BMSCs. A total of 72 BALB/c nude mice were used to establish xenograft models with glioma U251 cells and were divided into 6 groups (n = 12) including negative control group, nude mouse model group, lentiviral empty vector transfection into BMSC group, IL-12 gene lentivirus transfection into BMSC group and FYD treatment of IL-12 lentivirus-transfected BMSC group. After treatment for 14 days, all mice were sacrificed to collect tumor tissue and serum for more detection, such as distribution of BMSCs, cell apoptosis in xenograft tumors, serum IL-12 and INF-γ levels, mouse weight and tumor volume were measured.Results: There were significantly more apoptotic cells in tumor tissue in IL-12 gene transfected group, FYD treatment group and FYD combining with IL-12 gene transfected group than that in the model group (P < 0.05). The FYD+IL-12+BMSC group showed significantly higher Bax and lower Bcl-2 expression (P < 0.05), and serum IL-12 and INF-γ levels (P < 0.05) were higher than that in all other groups. After the intervention, this group also showed a strong inhibitory effect against tumor growth (P < 0.05).Conclusions: This study suggested FYD treatment combined with IL-12 gene-modified BMSCs shows synergistic antitumor effect in glioma-bearing nude mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Antitumor Effect of IL-12 Gene-modified Bone Marrow Mesenchymal Stem Cells Combined With Fuzheng Yiliu Decoction in an in Vivo Glioma Nude Mouse Model

Xie

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Integrated palliative care is focused and seems as rational anti-cancer way for advanced cancer patients with low toxicity and moderate effectiveness. Herbal extractive medicines represent relatively low-toxicity and anti-cancer ability of multitargets by regulating tumor microenvironment and immune system [9][10][11]. According to clinical studies, while the late-stage patients who had been failure with second-line or later treatment, integrated palliative care that includes herbal extractive medicine…”

mentioning

confidence: 99%

Report the Effective of Integrated Palliative Care using for Advanced Cancer as Second-Line or Later Treatment by Herbal Extractive Medicine

2019

ACRCI

View full text Add to dashboard Cite

Lung cancer (LC), hepatocellular carcinoma (HCC) and pancreatic cancer (PC) are severe malignant cancer. According to GLOBOCAN 2012 report, accounting for 19.45% of all newly diagnosed pancreatic cancer cases in China and 19.27% of all deaths from pancreatic cancer worldwide [1]. Usually, surgery, chemotherapy, radiation therapy and target therapy are used as the first line treatment. Surgery should have been a potentially curative therapy for early stage lung cancer, hepatocellular carcinoma and pancreatic cancer [2], however, many patients are not eligible for surgery [3]. For instant, surgical resection may offer a 5-year survival up to 70% in liver cancer patients, but for patients with advanced disease, surgical resection is an option for less than 20% [4]. Recently, PD-1 and PD-L1 anti-body therapy had been approved in lung and liver cancer, but no standard treatments for such stage patients after 1 st /2 nd line failure are recommended.Nowadays, the median overall survival (OS) for late-stage liver, lung and pancreatic cancer were 7.9 months, 8.2 and 5.3 months, respectively [1,[5][6][7][8]. Integrated palliative care is focused and seems as rational anti-cancer way for advanced cancer patients with low toxicity and moderate effectiveness. Herbal extractive medicines represent relatively low-toxicity and anti-cancer ability of multitargets by regulating tumor microenvironment and immune system [9][10][11]. According to clinical studies, while the late-stage patients who had been failure with second-line or later treatment, integrated palliative care that includes herbal extractive medicine

show abstract

The Protective Effects and Potential Mechanisms of Ligusticum chuanxiong: Focus on Anti‐Inflammatory, Antioxidant, and Antiapoptotic Activities

Shi

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Ligusticum chuanxiong (LC) is a Chinese materia medica which is widely used in clinical settings to treat headaches, blood extravasation, and arthritis. Recent studies demonstrate that LC possesses versatile pharmacological functions, including antiatherosclerosis, antimigraine, antiaging, and anticancer properties. Moreover, LC also shows protective effects in the progression of different diseases that damage somatic cells. Oxidative stress and inflammation, which can induce somatic cell apoptosis, are the main factors associated with an abundance of diseases, whose progresses can be reversed by LC. In order to comprehensively review the molecular mechanisms associated with the protective effects of LC, we collected and integrated all its related studies on the anti-inflammatory, antioxidant, and antiapoptotic effects. The results show that LC could exhibit the mentioned biological activities by modulating several signaling pathways, specifically the NF-κB, Nrf2, protein kinase, and caspase-3 pathways. In future investigations, the pharmacokinetic properties of bioactive compounds in LC and the signaling pathway modulation of LC could be focused.

show abstract

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Cited by 4 publications

References 96 publications

Antitumor Effect of IL-12 Gene-modified Bone Marrow Mesenchymal Stem Cells Combined With Fuzheng Yiliu Decoction in an in Vivo Glioma Nude Mouse Model

Antitumor Effect of IL-12 Gene-modified Bone Marrow Mesenchymal Stem Cells Combined With Fuzheng Yiliu Decoction in an in Vivo Glioma Nude Mouse Model

Report the Effective of Integrated Palliative Care using for Advanced Cancer as Second-Line or Later Treatment by Herbal Extractive Medicine

The Protective Effects and Potential Mechanisms of Ligusticum chuanxiong: Focus on Anti‐Inflammatory, Antioxidant, and Antiapoptotic Activities

Contact Info

Product

Resources

About