Arctic pharmacognosia II. Devil's club, Oplopanax horridus

Smith, G. Warren

doi:10.1016/0378-8741(83)90005-3

Cited by 18 publications

(11 citation statements)

References 9 publications

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“…Polyynes were regarded to be responsible for many bioactivities of Oplopanax horridus, which has long history of medicinal use and as a dietary supplement. O. horridus was well-known and marketed in North America as Devil's Club extracts, which are also edible as a respiratory stimulant and expectorant, and used for rheumatoid arthritis, autoimmune conditions, eczema, type II diabetes, external and internal infections [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activities of Polyynes from the Root Bark of Oplopanax horridus and Their Acetylated Derivatives

et al. 2014

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Six polyynes OH-1~6, some of which are occur naturally in acetylated form, had been isolated and identified from the root bark of Oplopanax horridus (Devil's Club), a natural dietary supplement and medicinal plant in North America. During the evaluation of the polyynes' potential anticancer activities, sixteen more acetylated derivatives OHR-1~16 have synthesized and their anti-proliferation activity on MCF-7, MDA-MB-231, A549, HepG2 and LO2 cells assayed to elucidate their structure-activity relationships. The results showed that OH-1 ((3S, 8S)-falcarindiol) had the most potent anticancer activity, with IC50 values of 15.3, 23.5, 7.7 and 4.7 μM on MCF-7, A549, HepG2 and MDA-MB-231 cells, respectively. For the primary structure-activity relationship, the anticancer activities of polyynes become weaker if their hydroxyl groups are acetylated, the terminal double bonds transformed into single bonds or they contain one more methylene group in the main skeleton chain.

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Section: Introductionmentioning

confidence: 99%

Anticancer Activities of Polyynes from the Root Bark of Oplopanax horridus and Their Acetylated Derivatives

et al. 2014

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“…The early pharmacognostic and pharmacological observations of O. horridus have been reviewed [8, 39, 40]. Modern pharmacological studies on O. horridus were limited.…”

Section: Discussionmentioning

confidence: 99%

High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: Comparison of stem and berry extracts

Wang¹,

Aung²,

Mehendale³

et al. 2010

Fitoterapia

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Oplopanax horridus or devil’s club is a herbal medicine distributed in North America. The constituents and pharmacological activities of O. horridus (OPH) are largely unknown. In this study, we assayed OPH stem and berry extracts using high performance liquid chromatography (HPLC). The anticancer potentials of extracts on different human cancer cell lines (SW-480, HCT-116, HT-29, MCF-7 and NSCLC) were determined by MTS method. The effect of stem extract on cancer cell cycle, expression of cyclin A, and apoptosis were assayed using flow cytometry. HPLC data showed that the composition of OPH stem extract is more complicated than the berry extract. The wavelength of maximum absorption of the major constituent in stem and berry is 196.0 nm and 201.9 nm, respectively. Compared to the berry extract, the stem extract showed significant potent antiproliferative effect on all the studied cell lines. The stem extract at 0.1 mg/ml arrested cancer cells in S- and G2/M-phases, and significantly induced expression of cyclin A. After treatment with 0.1 mg/ml of stem extract for 72 h, apoptotic cells were increased to 45.2%, while control was 9.6%. The cell cycle arrest and induction of apoptosis may play a critical role in cancer chemoprevention by Oplopanax horridus stem extract.

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“…Pharmacological studies have shown that O. horridus extract and its constituents displayed hypoglycemic (Smith, 1983), antibacterial (Inui, 2008; Inui et al, 2007a), anti-fungal (Kobaisy et al, 1997) and anti-viral properties. Recently, the O. horridus extract was found to have potential anticancer activity on a number of cancer cell lines in vitro (Tai et al, 2009; Tai et al, 2006; Wang et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.)

Sun

et al. 2010

Journal of Ethnopharmacology

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Ethnopharmacological relevance-Devil's Club Oplopanax horridus (Sm.) Miq. is a widely used folk medicine in the Pacific Northwest such as Alaska and British Columbia for treating a variety of ailments including arthritis, cold, fever, infections, diabetes and cancer.Aim of the study-To investigate hydrophobic constituents and their potential anticancer activity from Devil's Club O. horridus. Materials and methods-The root bark of O. horridus (Sm.) Miq was isolated by chromatographic techniques. Structures of isolated compounds were identified by spectroscopic methods and comparison with published data. The anti-proliferation of isolated hydrophobic constituents in human breast cancer MCF-7 cells, human colon cancer SW-480 and HCT-116 cells were tested. The potential mechanism of anti-proliferation was also investigated using cell cycle and apoptosis assays.Results and discussion-Six compounds were isolated and structurally identified as 9,17-octadecadiene-12,14-diyne-1,11,16-triol, 1-acetate (1), oplopandiol acetate (2), falcarindiol (3), oplopandiol (4), trans-nerolidol (5) and t-cadinol (6). These compounds showed potential anticancer activities on human breast cancer and colon cancer cells, of which compound 3 possesses the strongest activity. Further cell cycle and apoptosis test by flow cytometry showed the polyacetylenes 1-4 induced HCT-116 cell arresting in G2/M phase and inhibited proliferation by the induction of apoptosis at both earlier and later stage.Conclusion-These results provide promising baseline information for the potential use of O. horridus as well as some of the isolated compounds in the treatment of cancer.

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Arctic pharmacognosia II. Devil's club, Oplopanax horridus

Cited by 18 publications

References 9 publications

Anticancer Activities of Polyynes from the Root Bark of Oplopanax horridus and Their Acetylated Derivatives

Anticancer Activities of Polyynes from the Root Bark of Oplopanax horridus and Their Acetylated Derivatives

High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: Comparison of stem and berry extracts

Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.)

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